Bone Morphogenetic Protein-7 (BMP-7)
Immunohistochemical expression of osteocalcin, transforming growth factor beta 1 and bone morphogenetic protein 7 in fibrous dysplasia and ossifying fibroma of the jaw bones (a comparative study)
... increased bone mineral density. It is therefore, used as biomarker for bone formation process and also has a role in regulation of osteoblast function (Lee et ...in bone matrix, it is a regulator of ...
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Original Article Inhibitory effect of bone morphogenetic protein-7 on hepatic fibrosis in rats
... production. Bone morphogenetic protein-7 (BMP-7), as a member of the TGF-β 1 superfamily, has been well proved to be capable of reversing renal fibrosis in ...of ...
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Role of osteogenic protein-1/bone morphogenetic protein-7 in spinal fusion
... Osteogenic protein-1 (OP-1), also known as bone morphogenetic protein-7 (BMP-7), is a protein in the TGF-β family of cellular proteins that has shown potential for ...
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Original Article Bone morphogenetic protein-7 promoted the differentiation of bone marrow-derived mesenchymal stromal cells towards chondrocytes
... Objectives: Bone marrow stromal cells (BMSCs) have been investigated for their use in the treatment of Osteoarthritis (OA) in animal models, but this approach is challenged by their poor ability to differentiate ...
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Weekly intra articular injections of bone morphogenetic protein 7 inhibits osteoarthritis progression
... of BMP-7 in cartilage tissue At 1 hour and 1, 2, 4, and 7 days after intra-articular injection of 500 ng BMP-7 or PBS into normal knees, rabbits were killed, and cartilage tissue from ...
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Intra-articular delivery of extracellular vesicles secreted by chondrogenic progenitor cells from MRL/MpJ superhealer mice enhances articular cartilage repair in a mouse injury model
... After validation by qRT-PCR, three miRNAs (miR- 148a-3p, miR-221-3p, miR-222-3p) were observed to be significantly upregulated, while four miRNA (let-7b-5p, miR-22-3p, miR-125a-5p, miR-26a-5p) expression in MRL-EVs was ...
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Application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases
... BMC: Bone marrow cells; BMMSC: Bone marrow-derived mesenchymal stromal cells; BMP-7: Bone morphogenetic protein-7; CKD: Chronic kidney disease; DCs: Dendritic ...
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Bone Morphogenetic Protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis
... that BMP-7 was able to reverse the TGF- b -induced EMT in human proximal tubule cells by using high concentrations of recombinant BMP-7 (100 ...and BMP-7 compared to TGF- b ...
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Hypertrophy is induced during the in vitrochondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein 2 and bone morphogenetic protein 4 gene transfer
... express BMP-2 display a significant level of tissue hypertrophy and osteophyte formation, when transplanted orthotopically to osteochondral defects [14] or ectopically [15,49] in small ani- mal ...express ...
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Bone Morphogenetic Protein (BMP)-4 and BMP-7 regulate differentially Transforming Growth Factor (TGF)-β1 in normal human lung fibroblasts (NHLF)
... [17,18]. BMP-7 is thought to have inhibitory effects since it is able to counteract TGF- β1-induced fibrotic effects in vitro and to reverse estab- lished fibrosis in organs as diverse as the kidney, heart ...
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Simultaneous gene transfer of bone morphogenetic protein (BMP) 2 and BMP 7 by in vivo electroporation induces rapid bone formation and BMP 4 expression
... human BMP-2 gene expression vector (pCAGGS-BMP-2) and showed that transferring the BMP-2 gene into rat skel- etal muscles by in vivo transcutaneous electroporation induced ectopic bone ...
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Specific detection of clinical samples, systematic functional investigations, and transcriptome analysis reveals that splice variant MUC4/Y contributes to the malignant progression of pancreatic cancer by triggering malignancy related positive feedback loops signaling
... containing 7; BMP2: Bone morphogenetic protein 2; cDNA: Complementary DNA; CI: Confidence interval; Ct: Threshold cycle value; CTHRC1: Collagen triple helix repeat-containing 1; DEGs: ...
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The essential role of bone morphogenetic protein (BMP) signaling in organogenesis
... especially in the early steps in blood vessel formation. Since Bmper expression is first detected at E 7.0 (mid-gastrulation) 183 , Bmper null embryos are expected to survive until at least that stage. For these reasons, ...
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Paracrine effects of human amniotic epithelial cells protect against chemotherapy-induced ovarian damage
... (TGF-β), bone morphogenetic growth protein-4 (BMP-4) and so on ...fluorescent protein (GFP) migrated into the injured ovary and differ- entiated into follicle-stimulating hormone ...
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Elevated extracellular matrix production and degradation upon bone morphogenetic protein 2 (BMP 2) stimulation point toward a role for BMP 2 in cartilage repair and remodeling
... of BMP on intact cartilage. Indeed, BMP-2 exposure led to degradation of aggrecan as shown by the increase in MMP- and ADAMTS (a disintegrin and metallopro- teinase with thrombospondin motifs)-mediated ...
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Bone conditioned media (BCM) improves osteoblast adhesion and differentiation on collagen barrier membranes
... Real-time RT-PCR was used to investigate the expression of genes encoding osteoblast differentiation markers. Total RNA was isolated using High Pure RNA Isolation Kit (Roche, Switzerland) at 5 days for osteoblast ...
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Azoramide, a novel regulator, favors adipogenesis against osteogenesis through inhibiting the GLP-1 receptor-PKA-β-catenin pathway
... G protein-coupled re- ceptors, which are highly expressed on islet β cells ...the bone-inducing ef- fects of MSC in response to exendin-4 (Ex-4), an agonist of ...
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rSjp40 inhibits activated hepatic stellate cells by promoting nuclear translocation of YB1 and inducing BMP 7/Smad1/5/8 pathway
... morphogenic protein (BMP)-7, a member of the TGF-β superfamily, has been reported to counter- act some of the profibrogenic actions of TGF-β1 ...[6, 7]. In liver fibrosis, the involve- ment of ...
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A crucial role of caspase 3 in osteogenic differentiation of bone marrow stromal stem cells
... Bone analyses by microCT and pQCT. Distal femoral metaphyses were ana- lyzed by μCT (μCT-20; SCANCO USA Inc.). Scanning regions were confined to secondary spongiosa and were approximately 0.30 mm in thickness. ...
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Scleraxis and osterix antagonistically regulate tensile force responsive remodeling of the periodontal ligament and alveolar bone
... (B) Schematic of the sagittal plane of the maxillary molars with an inserted elastic band. The black dashed line indicates the sectioning level for the transverse sections shown in C-H. (C-H) Undecalcified frozen ...
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