Bone morphogenetic protein (BMP)-7
Bone Morphogenetic Protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis
... Background: Bone Morphogenetic Protein (BMP)-7 is protective in different animal models of acute and chronic kidney ...Methods: BMP-7 mRNA was quantified using real-time ...
14
Role of osteogenic protein-1/bone morphogenetic protein-7 in spinal fusion
... Osteogenic protein-1 (OP-1), also known as bone morphogenetic protein-7 (BMP-7), is a protein in the TGF-β family of cellular proteins that has shown potential for ...
11
Original Article Bone morphogenetic protein-7 promoted the differentiation of bone marrow-derived mesenchymal stromal cells towards chondrocytes
... Objectives: Bone marrow stromal cells (BMSCs) have been investigated for their use in the treatment of Osteoarthritis (OA) in animal models, but this approach is challenged by their poor ability to differentiate ...
10
Simultaneous gene transfer of bone morphogenetic protein (BMP) 2 and BMP 7 by in vivo electroporation induces rapid bone formation and BMP 4 expression
... Human BMP-7 cDNA was obtained by PCR with pUC BMP-7 as the template and the following primers: human BMP-7 forward primer, 5'-GAG AGA GAG AAGCTT GGA TCC ATG GTG GCC GGG ACC CGC ...
11
Elevated extracellular matrix production and degradation upon bone morphogenetic protein 2 (BMP 2) stimulation point toward a role for BMP 2 in cartilage repair and remodeling
... Bone morphogenetic protein-2 (BMP-2) is one of the candi- date growth factors with good potential in cartilage tissue engineering as well as cartilage ...repair. BMP-2 belongs to the ...
11
The essential role of bone morphogenetic protein (BMP) signaling in organogenesis
... especially in the early steps in blood vessel formation. Since Bmper expression is first detected at E 7.0 (mid-gastrulation) 183 , Bmper null embryos are expected to survive until at least that stage. For these reasons, ...
114
Hypertrophy is induced during the in vitrochondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein 2 and bone morphogenetic protein 4 gene transfer
... gous bone marrow stromal cells for the repair of full-thickness articular cartilage defects in humans ...with bone morphogenetic proteins (BMPs), members of the TGF-β ...endochondral bone ...
15
Intra-articular delivery of extracellular vesicles secreted by chondrogenic progenitor cells from MRL/MpJ superhealer mice enhances articular cartilage repair in a mouse injury model
... After validation by qRT-PCR, three miRNAs (miR- 148a-3p, miR-221-3p, miR-222-3p) were observed to be significantly upregulated, while four miRNA (let-7b-5p, miR-22-3p, miR-125a-5p, miR-26a-5p) expression in MRL-EVs was ...
14
Application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases
... BMC: Bone marrow cells; BMMSC: Bone marrow-derived mesenchymal stromal cells; BMP-7: Bone morphogenetic protein-7; CKD: Chronic kidney disease; DCs: Dendritic ...
9
Paracrine effects of human amniotic epithelial cells protect against chemotherapy-induced ovarian damage
... (TGF-β), bone morphogenetic growth protein-4 (BMP-4) and so on ...fluorescent protein (GFP) migrated into the injured ovary and differ- entiated into follicle-stimulating hormone ...
13
A crucial role of caspase 3 in osteogenic differentiation of bone marrow stromal stem cells
... and protein concentrations were measured using Bio-Rad Protein Assay (Bio-Rad Laboratories ...of protein were applied to each lane and separated on Tris-Glycine SDS-PAGE gel (Novex; Invitrogen ...
11
Scleraxis and osterix antagonistically regulate tensile force responsive remodeling of the periodontal ligament and alveolar bone
... (B) Schematic of the sagittal plane of the maxillary molars with an inserted elastic band. The black dashed line indicates the sectioning level for the transverse sections shown in C-H. (C-H) Undecalcified frozen ...
10
Ethyl acetate fraction of Huogu formula inhibits adipogenic differentiation of bone marrow stromal cells via the BMP and Wnt signaling pathways
... The inverse correlation of adipogenic and osteogenic lineage differentiation in BMSCs is mediated by diverse signaling pathways. Some of these factors play an opposite role with respect to lineage determination, while ...
12
Bone conditioned media (BCM) improves osteoblast adhesion and differentiation on collagen barrier membranes
... Results from the present study also confirm that BCM is able to significantly increase gene expression of BSP and OCN, known markers of osteoblast differentiation. While the significant increase was observed at 1.5 times ...
7
Potential role of herbal remedies in stem cell therapy: proliferation and differentiation of human mesenchymal stromal cells
... Stem cell therapy has revolutionized modern clinical therapy with the potential of stem cells to differentiate into many different cell types which may help to replace different cell lines of an organism. Innumerous ...
8
The involvement of follistatin like protein 1 in osteoarthritis by elevating NF κB mediated inflammatory cytokines and enhancing fibroblast like synoviocyte proliferation
... disco-interacting protein 2 homolog a (DIP2a) from Drosophila was a candidate receptor for FSTL1 in endothelial cells ...TGF-β, bone morphogenetic protein (BMP)-2⁄4, and their receptors ...
10
Osteoblast differentiation of rabbit adipose-derived stem cells by polyethylenimine-mediated BMP-2 gene transfection in vitro.
... mL, BMP-2 (Primer1 upstream) 1.2 mL, BMP-2 (Primer2 downstream) ...electrophoresis. BMP-2 primers were: 5'-GCC CTT TTC CTC TGG CTG AT-3' and 5'- TTG ACC AAC GTC TGA ACA ATG ...
10
ChIP'ing the mammalian genome: technical advances and insights into functional elements
... Other important factors to be considered while doing ChIP include the antibody specificity and the fine balance between the crosslinking stringency and sonication condi tions. The robustness of ChIP to differentially ...
10
<p>Elevated Levels of circRUNX1 in Colorectal Cancer Promote Cell Growth and Metastasis via miR-145-5p/IGF1 Signalling</p>
... Figure 7 circRUNX1 facilitated cell proliferation by relieving repression of miR-145-5p for IGF1 expression. (A) Schematic of the predicted miR-145-5p binding site in circRUNX1 and mutant binding site. ...
14
Osteoimmunology and osteoporosis
... BMD, bone mineral density; BMP, bone morphogenetic protein; CRP, C-reactive protein; CT, computed tomography; DKK, Dikkoppf; DXA, dual-energy x-ray absorptiometry; DXR, ...
16