BRAF V600E
Identification of coexistence of BRAF V600E mutation and EZH2 gain specifically in melanoma as a promising target for combination therapy
... and BRAF V600E mutation screening Genomic DNA was extracted from formalin-fixed, paraf- fin-embedded sections using a QIAamp DNA FFPE Tis- sue Kit (Qiagen, Valencia, CA, ...the BRAF V600E ...
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Targeting Notch enhances the efficacy of ERK inhibitors in BRAF- V600E melanoma
... to BRAF inhibitors [11-13, 15], we first examined the mutation status and expression of this tumor suppressor (Figure 1D, Table ...mutant BRAF-V600E and PTEN deletion [17] were sensitive to SCH984 ...
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BRAF V600E mutations are the most common genetic mutation in PTC and the relationship between BRAF V600E mutations and PTC has recently been a focus of research. The aim of the present study was to deter-
... of BRAF V600E mutations in PTC has been controversial in different stud- ies recently, Ito et ...investigated BRAF V600E mutations in 631 patients with PTC hav- ing median follow-up periods of ...
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Different effects of the inhibition of Src activity on Akt/PKB in melanoma cells with wild BRAF and mutated BRAF V600E
... inhibits BRAF [3] and achieves clinical responses in patients with Braf—mutant ...activating V600E mutations in Braf gene (BRAF V600E), an oncogene known to be critical for the ...
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NRAS Q61R, BRAF V600E immunohistochemistry: a concomitant tool for mutation screening in melanomas
... of BRAF V600E mutated melanoma positive on COBAS® but negative on IHC ...and BRAF V600E mutated samples were also reported by Skorokhod et ...a BRAF K601Q mu- tation instead of a ...
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Frequency of BRAF V600E mutations in 969 central nervous system neoplasms
... of BRAF and the putative homologs A-Raf proto-oncogene serine/threonine protein kinase (ARAF) and Raf-1 proto-oncogene serine/threo- nine protein kinase (CRAF) ruled out cross reactivity ...detecting BRAF ...
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The BRAF V600E mutation: what is it really orchestrating in thyroid cancer?
... As future research continues to focus on finding more selective and targeted compounds to truly personalize cancer care, researchers will have to be able to understand the molecular fingerprints and subsequent actions of ...
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Original Article BRAF mutation in breast cancer by BRAF V600E mutation-specific antibody
... detecting BRAF mutation in various neoplasms [7, 16, ...using BRAF V600E mutation specific antibody was reported to be more specific and more sensitive compared to Sanger sequenc- ing method, ...
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EGFR blockade prevents glioma escape from BRAF V600E targeted therapy
... anti-glioma strategy. If this therapeutic approach were to be used in treating glioma patients, a factor that may prove critically important in determining its success is therapeutic access to brain and brain tumor. ...
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Original Article Immunohistochemistry is highly sensitive and specific for detecting the BRAF V600E mutation in papillary thyroid carcinoma
... that BRAF V600E mutation was more common among patients with solid tumor sub- type than among patients with follicular PTC ...the BRAF V600E mutation was extremely prev- alent among patients ...
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Immunohistochemistry is highly sensitive and specific for detection of BRAF V600E mutation in pleomorphic xanthoastrocytoma
... neuropathology, BRAF V600E mutation- specific immunohistochemistry has a potential clinically relevant ...of BRAF V600E mutant protein is an accurate and reliable alternative method that may ...
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Value of BRAF V600E in High Risk Thyroid Nodules with Benign Cytology Results
... FNAs were performed under US guidance with a 23-ga needle attached to a 2-mL syringe. Each lesion was aspirated in 2–3 passes in different directions. The aspirates were expelled on glass slides, smeared, and immediately ...
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Sensitive detection of BRAF V600E mutation by Amplification Refractory Mutation System (ARMS)-PCR
... for BRAF V600E mutation testing, including dideoxy sequencing, colorimetric Mutector assay, allele-specific real-time PCR, pyrose- quencing, high resolution melting (HRM) analysis and COLD-PCR ...detect ...
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False negative BRAF V600E mutation results on fine needle aspiration cytology of papillary thyroid carcinoma
... The BRAF V600E mutation results of 221 PTC nodules confirmed as PTC on permanent pathology between De- cember 2011 and June 2013 were retrospectively ...performed BRAF V600E mutation testing ...
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Dabrafenib and trametinib activity in a patient with BRAF V600E mutated and microsatellite instability high (MSI-H) metastatic endometrial cancer
... that BRAF and MEK inhibitors may exert significant anti- tumor activity in BRAF V600E mutated endometrial can- cers, calling for prospective confirmatory clinical studies to be carried out in this ...
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BRAF V600E mutation in Juvenile Xanthogranuloma family neoplasms of the central nervous system (CNS-JXG): a revised diagnostic algorithm to include pediatric Erdheim-Chester disease
... the BRAF V600E point muta- tion, which included 10 pediatric CNS-JXG neoplasms that were included in the primary ...pediatric BRAF V600E (n = 5) and BRAF wild-type (n = 5) CNS-JXG ...
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Adult classical glioblastoma with a BRAF V600E mutation
... Most BRAF mutations occur at codon 600, which resides within the activation loop of the kinase domain, and 80% to 90% of these mutations gen- erate a protein with a glutamic acid (E) residue substituted for the ...
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Review Article Pleomorphic xanthoastrocytoma inside lateral ventricle: a rare case report and literature review
... Abstract: Pleomorphic xanthoastrocytoma (PXA) is a relatively rare, low grade astrocytic tumor that usually affects children as well as young adults. The reported cases were predominantly located superficially in the ...
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Diagnostic Utility of Molecular and Imaging Biomarkers in Cytological Indeterminate Thyroid Nodules.
... the cost-effectiveness of BRAF V600E mutation analysis in indeterminate thyroid nodules based 267.. on a mere 4.6% mean prevalence of the mutation (87).[r] ...
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Case Report Clinicopathologic changes and molecular finding of epithelioid pleomorphic xanthoastrocytoma: a case report
... the BRAF (V600E) mutation, which is found in approximately 70% of PXAs [14], while the epithelioid glioblastoma (eGBM) has a mutation rate of approximately ...the BRAF (V600E) mutation was ...
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