BREAK REPAIR
TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1
... DNA repair, including in HR, NHEJ, single-strand break repair and base excision repair ...NHEJ repair defect in hamster and murine cells after ionizing radiation (IR), manifesting in ...
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Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN
... We have carried out a large-scale investigation of the expression of the double strand break repair proteins γ-H2AX, ATM and Ku70 in colorectal cancer. We found that chromosomal instability was associated ...
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Contribution of telomerase RNA retrotranscription to DNA double strand break repair during mammalian genome evolution
... the repair of DNA double-strand breaks that were fixed in the genome in the course of ...the break site or with processing of the ends produced by the break involving deletions, insertions or target ...
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The mus309 mutation, defective in DNA double strand break repair, increases the frequency of X ray induced somatic crossing over in Drosophila melanogaster, but the effect is not dose rate dependent
... Effect of a 1000 R dose of hard X-rays, with two dif- ferent dose-rates viz. 300 and 1000 R/min on somatic crossing over in the X chromosome of Drosophila melanogaster was studied in two different genotypes. Irradiation ...
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Original Article Tob1 enhances radiosensitivity of hepatocellular carcinoma via inhibiting DNA double-strand break repair
... DNA dependent protein kinase (DNA-PK) is a key enzyme during DNA repair [16]. The result of Figure 3C proved that DNA-PK activity was significantly increased by irradiation, while Tob1 significantly inhibited the ...
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Targeting DNA double strand break repair with hyperthermia and DNA-PKcs inhibition to enhance the effect of radiation treatment
... In all cell lines, more persisting DNA-DSB were detected at 6 h, after applying the combined treatment modalities as compared to radiation treatment alone. At 24 h after treatment, the numbers of γ-H2AX foci were reduced ...
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DNA double strand break repair enzymes function at multiple steps in retroviral infection
... DNA repair enzymes in retroviral replication [38- ...DSB repair enzymes such as Mre11 and NBS1 is lethal, and there are only hypomorphic mutant cell lines ...
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Radio-resistant mesenchymal stem cells: mechanisms of resistance and potential implications for the clinic
... strand break repair and evasion of ...and repair pathways in the creation of a radioresistant MSC phenotype is outlined, and the roles of apoptosis, senescence and autophagy regarding the reported ...
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Double-strand break repair and colorectal cancer: gene variants within 3 UTRs and microRNAs binding as modulators of cancer risk and clinical outcome
... In the present study, we analysed the association of polymorphisms in predicted microRNA target sites of double-strand breaks (DSBs) repair genes with colorectal cancer (CRC) risk and clinical outcome. Twenty-one ...
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Chemotherapeutic compounds targeting the DNA double strand break repair pathways: the good, the bad, and the promising
... The repair of DNA double-strand breaks (DSBs) is a critical cellular mechanism that exists to ensure genomic ...in repair opens up a potential therapeutic window in the treatment of ...DNA repair ...
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DNA damage response and repair in perspective: Aedes aegypti, Drosophila melanogaster and Homo sapiens
... D-loop structures can be solved by three pathways: double-strand break repair (DSBR), synthesis-dependent strand annealing (SDSA) or break induced replication (BIR) [50]. In the DSBR the D-loop is ...
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Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing
... chromosomal break repair defect in SOD1 G93A Aptx2/2 cells reflects a role for APTX in nuclear DNA repair since the comet assay does not detect mitochondrial DNA breaks ...
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The role of ChlR1 in DNA replication, DNA damage repair and cohesion establishment
... damage repair and cancer development is the association of FHL2 with BRCA1 ...strand break repair through HR ...damage repair proteins including RAD51 [301] and the MRN complex ...damage ...
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Imprecision and DNA break repair biased towards incompatible end joining in leukemia
... aberrant repair of DSBs can lead to mis-joining of distant DNA ends, generating deletions, inversions or complex rearrangements of ...main repair pathway for G1 or G0 arrested ...
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Exome sequencing reveals MCM8 mutation underlies ovarian failure and chromosomal instability
... dsDNA break repair, we tested fibroblasts from the affected sisters for hypersensitivity to chromosomal ...chromosomal break repair was deficient in fibroblasts from the affected individuals, ...
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A Novel Link Break Distance (LBD) and Pre emptive Threshold Alarm (PTA) based Link Repair Approach for MANET
... route repair scheme can lead for effective transmission without worrying about the path optimality & link condition, which has been addressed as a problem in local recovery ...
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An improved link repair method in AODV routing protocol
... MANET is a collection of autonomous arbitrarily located wireless nodes with no fixed infrastructure. And it has more applications in military or civilian environments. AODV as an on-demand routing protocol has become the ...
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Emergence of rationally designed therapeutic strategies for breast cancer targeting DNA repair mechanisms
... cient repair of toxic O6-methyl- guanine adducts or due to defects in the MMR, which, when functional, contributes to TMZ cell ...mismatch repair-defi cient human colon and ovarian cancer cells ...
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A Dam Break Analysis Using HEC RAS
... Dam provides many benefits for our society, but floods resulting from the failure of constructed dams have also produced some of the most devastating disaste- rs of the last two centuries. Simulation of dam break ...
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A break?
... complete break from the ways of ordinarily doing things, even from the ways in which we respond – through demonstrations – to the ways in which we are ...a break from the deteriorating conditions in which ...
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