Breast Stem Cancer Cells
Human breast cancer cell lines contain stem like cells that self renew, give rise to phenotypically diverse progeny and survive chemotherapy
... within cancer cells that selects for clonal expansion and evolution of more aggressive tumor behaviors over ...drift, breast cancers do not radically change their phenotype, even after many years or ...
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NOTCH1 is a poor prognostic factor for breast cancer and is associated with breast cancer stem cells
... primary breast cancer samples, IHC evidence of NOTCH1 was significantly asso- ciated with TNM stage and ...of cancer stem cells, and correlated with ...that breast cancer ...
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Requirement of the transcription factor YB-1 for maintaining the stemness of cancer stem cells and reverting differentiated cancer cells into cancer stem cells
... glioblastoma cells into glio- blastoma stem cells ...of cancer stem cells, leading to the decrease of sphere-forming ability and downregulation of stemness genes of cancer ...
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Influence of the Metastatic Microenvironment on Stem-like Human Breast Cancer Cells
... Breast cancer is currently a treatable disease, but a lack of effective therapies in the metastatic setting render breast cancer largely incurable once the cancer has disseminated ...
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Breast cancer stromal fibroblasts promote the generation of CD44+CD24- cells through SDF-1/CXCR4 interaction
... adult stem cells and differentiation of progenitor cells along a particular ...mammary stem cell self-renewal, but modulation of this pathway had no significant effect on differentiated ...
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Breast cancer, stem cells and prospects for therapy
... The spectacular success of the tyrosine kinase inhibitor imatinib in chronic myeloid leukaemia provides a prototype for targeted therapeutics. While these therapeutics can induce dramatic tumour regression even in ...
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EMT and tumor metastasis
... tumor cells; FOXC1: Forkhead box C1; HER2: Human epidermal growth factor receptor 2; CSC: Cancer stem cells; EpCAM: Epithelial cellular adhesion molecule; HAT: Histone acetyl transferase; ...
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EMT, CTCs and CSCs in tumor relapse and drug-resistance
... driven cancer cells could lengthen progression- free survival ...liver cancer showed the EMT markers twist and Vimentin in ...lung cancer (NSCLC), resistance to EGFR inhibitors was associated ...
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Role of cancer stem cells in breast and prostate cancer
... the stem cell niche there is a cellular hierarchy based on the morphology, proliferation and differentiation potential of the cells and the clones of cells formed in the hierarchy are known as: ...
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Oncolytic vaccinia virus GLV 1h68 strain shows enhanced replication in human breast cancer stem like cells in comparison to breast cancer cells
... GI-101A cells resulted in cell population with CD44 + CD24 + ESA + and CD44 + CD24 - ESA + markers We examined whether the treatment of GI-101A cell line with TGF-β1, similar to HMLE cell line [13,14], would lead ...
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Nanoparticle Delivery of miR-34a Eradicates Long-term-cultured Breast Cancer Stem Cells via Targeting C22ORF28 Directly
... Although multiple molecules have been reported to be direct targets of miR-34a in stem cells [5, 28], the precise molecular mechanisms of long-term-cultured BCSC repressed by TV-miR-34a remain to be ...
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Effects of miRNAs on functions of breast cancer stem cells and treatment of breast cancer
... epithelial cells. Breast stem cells guarantee the maintenance of regenera- tion, lactation, and degenerative cycle of mammary ...gland stem cells are thought to have multiple ...
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Identification of genes involved in breast cancer and breast cancer stem cells
... in breast cancer and breast ...lung cancer, colon CSCs, lung CSCs, embryonic stem cells, and in a reference ...CsCs, cancer stem cells; ESCs, embryonic ...
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Cancer Stem Cells In Breast Cancer: A Review
... and stem cell mobilization and recruitment during development and during ...in breast cancer metastasis was first documented in ...in breast cancer cells is associated with ...
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Isolate and identified cancer stem cells by using MCF7 human breast cancer cell line, using mammospheres formation in two different methods
... of cells were collected after one day (24hours) by using new media and a new flask (Corning, ...the cells need four days to make spheres in ideal conditions; the images were shown under the microscope X4, ...
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Neural stem and progenitor cells in cancer and development
... characterized cancer stem or stem-like cells in leukemia, breast cancer, and brain tumors, and shown that these cells can self-renew, are multipotent, and can recapitulate ...
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Targeting specificity of dendritic cells on breast cancer stem cells: in vitro and in vivo evaluations
... target cells. From 0 to 24 hours, verapamil-resistant cells (VRCs) were cultured as adherent cells in the E-plate (96 wells) in groups 1 and 3–6, while group 2 had DCs and CTLs ...hours, cells ...
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Genistein decreases the breast cancer stem-like cell population through Hedgehog pathway
... the cancer stem cells, we decided to use mammosphere culture that was first used to isolate and expand mammary stem/pro- genitor cells by Dontu and colleagues [18], based on the ability ...
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Zoledronic acid prevents the tumor-promoting effects of mesenchymal stem cells via MCP-1 dependent recruitment of macrophages
... and breast cancer ...in breast tumor bearing mice by using BLI, and found that the development of tumors was inhibited by ZA ...of breast cancer in ...
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Cytokines, breast cancer stem cells (BCSCs) and chemoresistance
... in breast cancer chemoresist- ...chemo-sensitive breast cancer cells, lead- ing to de novo acquired drug resistance ...metastatic breast cancer cell line, knockdown of ...
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