broadly neutralizing antibodies
Susceptibility to Neutralization by Broadly Neutralizing Antibodies Generally Correlates with Infected Cell Binding for a Panel of Clade B HIV Reactivated from Latent Reservoirs
... CD4i antibodies commonly arise during infection (37) and have the potential to mediate ADCC against liganded versions of the Env protein, the addition of soluble CD4 (sCD4) mimetics has been necessary to increase ...
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Activity of Broadly Neutralizing Antibodies, Including PG9, PG16, and VRC01, against Recently Transmitted Subtype B HIV-1 Variants from Early and Late in the Epidemic
... certain antibodies was observed for viruses from some ...autologous neutralizing antibody responses, which are directed mainly against the variable regions of the viral enve- lope, it seems unlikely that ...
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Importance of Fc mediated functions of anti HIV 1 broadly neutralizing antibodies
... Anti-HIV-1 broadly neutralizing antibodies (BnAbs) exhibit an impressive capacity to protect against chimeric SIV- HIV (SHIV) challenges in macaques and potently reduce viremia in both SHIV-infected ...
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Selection Pressure on HIV-1 Envelope by Broadly Neutralizing Antibodies to the Conserved CD4-Binding Site
... developed broadly neutralizing ...this broadly reactive MAb that partially mimics CD4, all Env variants required CD4 for ...CD4bs antibodies continued to evolve in response to viral ...
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Broadly neutralizing antibodies with few somatic mutations and hepatitis C virus clearance
... of broadly neutralizing antibodies against HCV in serum (28, ...with broadly neu- tralizing serum and clearance of HCV have not been isolated to date, so it is not known whether these mAbs ...
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Broadly Neutralizing Antibodies Display Potential for Prevention of HIV-1 Infection of Mucosal Tissue Superior to That of Nonneutralizing Antibodies
... of broadly neutralizing antibodies (bnAbs) remains a key focus of human immunodeficiency virus type 1 (HIV-1) vaccine research; however, this goal has yet to be ...develop neutralizing ...
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HIV-1-Specific Chimeric Antigen Receptors Based on Broadly Neutralizing Antibodies
... single-chain antibodies for gene immunotherapy of cancers is increasing due to promising recent results, the earliest CAR therapeutic trials were done for HIV-1 infection in the late ...HIV-1 broadly ...
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Antibody Response to Hypervariable Region 1 Interferes with Broadly Neutralizing Antibodies to Hepatitis C Virus
... exposure of their epitopes and decreased steric hindrance by anti- HVR1 MAbs. Two sets of H77C E2 were first exposed to H77.16 (20 g/ml) at room temperature (RT). One (test) set was incu- bated at 40°C prior to ...
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Development of broadly neutralizing antibodies in HIV 1 infected elite neutralizers
... Broadly neutralizing antibodies (bNAbs), able to prevent viral entry by diverse global viruses, are a major focus of HIV vaccine design, with data from animal studies confirming their ability to ...
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Norovirus Escape from Broadly Neutralizing Antibodies Is Limited to Allostery-Like Mechanisms
... elicit antibodies (Abs) with broad strain recogni- tion that bind to regions that are difficult to mutate for ...which broadly neutralized all MNV strains ...cross-reactive antibodies but which the ...
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Broadly neutralizing antibodies targeted to mucin-type carbohydrate epitopes of human immunodeficiency virus.
... Inhibition of human immunodeficiency virus HIV infection in vitro by anti-carbohydrate monoclonal antibodies: peripheral glycosylation of HIV envelope glycoprotein gpl20 may be a target [r] ...
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Challenges on Induction of Broadly Neutralizing Antibodies for Optimization of HIV Vaccines Development and Vectored Immunoprophylaxis
... Ad35 neutralizing titers remained low after the second vaccination ...V1/V2-binding antibodies and reduce risk of HIV-1 acquisition, and provide evidence that vac- cine-induced V2 responses plausibly had a ...
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Mechanisms of escape from the PGT128 family of anti HIV broadly neutralizing antibodies
... Firstly, different mutations in the virus isolated from donor 36 can restore neutralization sensitivity towards bnAbs PGT128 and PGT130, secondly mutations in both the protein sequence a[r] ...
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Plasma deconvolution identifies broadly neutralizing antibodies associated with hepatitis C virus clearance
... serum-neutralizing antibodies have notable lim- ...monoclonal antibodies (mAbs) from B ...serum antibodies and reference mAbs (21), but these assays are confounded by the abundance of E1/E2 ...
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A Vaccine Based on the Rhesus Cytomegalovirus UL128 Complex Induces Broadly Neutralizing Antibodies in Rhesus Macaques
... Some investigators have demonstrated that tagged fusion pro- teins or derivative peptides of UL128, UL130, or UL131A induce Epi/EC-specific NAb for HCMV in mice or rabbits (21, 54, 55), suggesting that these UL128C ...
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Development of Broadly Neutralizing Antibodies and Their Mapping by Monomeric gp120 in Human Immunodeficiency Virus Type 1-Infected Humans and Simian-Human Immunodeficiency Virus SHIVSF162P3N-Infected Macaques
... most CD4bs-directed bnAbs, including VRC01 and its class (29), we generated another mutant, W479A, to complement D368R for plasma mapping and MAb isolation. The W479A mutation re- duces gp120-CD4 interaction by keeping ...
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Role of Human Immunodeficiency Virus Type 1 Envelope Structure in the Induction of Broadly Neutralizing Antibodies
... , which neutralize 40 to 50% of isolates, and PGT141 to -145, which neu- tralize 40 to 80% of strains (6, 145, 146). Most of the QNE-specific Abs show sensitivity for an N-linked glycan at position 160 in V2 (HXB2 ...
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Development of an anti-HIV vaccine eliciting broadly neutralizing antibodies
... found antibodies capable of neu- tralizing different virus subtypes ...of broadly neutral- izing anti-HIV antibodies (bNAbs), including 447-52D (V3 loop), b12 (CD4 binding site), 17b (co-receptor ...
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Towards HIV 1 remission: potential roles for broadly neutralizing antibodies
... with antibodies alone or antibodies plus a single inducer did not reduce the proportion of mice with rebound viremia ...allow antibodies to exert their effects ...
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HIV 1 cell to cell transmission and broadly neutralizing antibodies
... anti-HIV-1 antibodies, as soon as one week following initial viral exposure ...duced antibodies do not neutralize the virus [7]. The first neutralizing antibodies are detected two to three ...
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