bromodomain containing protein 4
<p>microRNA-612 suppresses the malignant development of non-small-cell lung cancer by directly targeting bromodomain-containing protein 4</p>
... Material and methods: Here, the expression level of miR-612 in NSCLC tissue specimens and a panel of cell lines were evaluated by RT-qPCR. Cell-Counting Kit 8, fl ow cytometry, Transwell migration and invasion, and in ...
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Proteasomal Degradation of the Papillomavirus E2 Protein Is Inhibited by Overexpression of Bromodomain-Containing Protein 4
... expression. However, since Brd4 is required for the expression of many cellular genes, it is not surprising that it can also affect expression from the CMV promoter. Importantly, because our experiments involved ...
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Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer.
... Background: Epigenetic information can be used to identify clinically relevant genomic variants single nucleotide polymorphisms (SNPs) of functional importance in cancer development. Super-enhancers are cell-specific DNA ...
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RETRACTED ARTICLE: Molecular mechanisms in progression of HPV-associated cervical carcinogenesis
... serine/threonine-specific protein kinase; AP-1: Activator protein 1; Bcl- 2: B-cell lymphoma 2; BRD4: Bromodomain-containing protein 4; CADM1: Cell adhesion molecule 1; CARM1: ...
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The bromodomain-containing protein Ibd1 links multiple chromatin-related protein complexes to highly expressed genes in Tetrahymena thermophila
... the bromodomain (BRD) present in SNF2/ Brg1 ...Additional protein domains that function in transcription complexes by recognizing some of the diverse histone post-translational modifica- tions (PTMs) ...
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Development of neurodevelopmental disorders: a regulatory mechanism involving bromodomain-containing proteins
... domain- containing protein; BAZ1A: Bromodomain adjacent zinc finger, 1A; BAZ1B: Bromodomain adjacent zinc finger, 1B; BCPs: Bromodomain- containing proteins; Brd1: The first ...
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Analysis of gene expression patterns by microarray hybridization in blood mononuclear cells of SLA DRB1 defined Canadian Yorkshire pigs
... BRD2, Bromodomain containing 2; CCL4, Chemokine (C-C motif) ligand 4; IL1B, Interleukin 1 beta; SLA-DQA, SLA class II DQ alpha; TLR2, Toll-like receptor 2; CASP1, Caspase 1; RPL19, Ribosomal ...
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The discovery of I-BRD9, a selective cell active chemical probe for bromodomain containing protein 9 inhibition
... X-ray crystal structures of 44 in the bromodomains of BRD9 and BRD4 BD1 provided insights into the interactions responsible for the observed selectivity and supported our hypothesis that led to the synthesis of the ...
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A Bromodomain-Containing Host Protein Mediates the Nuclear Importation of a Satellite RNA of Cucumber Mosaic Virus
... Function of BRP1 in the infection cycle of Q-satRNA. With the aim of elucidating the biological significance of BRP1-medi- ated nuclear importation of Q-satRNA, we tested the relative HV- dependent replication of ...
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Original Article Bromodomain 4 protein is a predictor of survival for urothelial carcinoma of bladder
... Paraffin sections (4 μm thick) were deparaffinized in xylene and rehydrated in grade alcohol, followed by boiling in 10 mmol/L of citrate buffer (pH 6.0) for antigen retrieval. After inhibition of endoge- nous ...
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Bromodomain Protein 4 Mediates the Papillomavirus E2 Transcriptional Activation Function
... promoter containing E2 bind- ing sites, depending upon the number and position of the binding sites within the promoter region ...E2 protein has been shown to bind a number of general cellular transcrip- ...
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Bromodomain-containing protein 7 (BRD7) as a potential tumor suppressor in hepatocellular carcinoma
... up data included clinical and laboratory examinations such as abdominal ultrasonography, liver function tests, serum AFP levels, and chest radiography. OS and RFS were used to measure prognosis in this study. OS was ...
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Epigenetic assays for chemical biology and drug discovery
... These are proximity-based assays that have successfully been used to study the activity of a wide range of targets [58–61]. The technology requires two bead types, termed donor beads and acceptor beads with the former ...
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Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Interacts with Bromodomain Protein Brd4 on Host Mitotic Chromosomes
... mosomes to ensure maintenance of viral episomes in dividing cells (1, 2, 10, 49, 50, 57). This tethering mechanism involves concomitant interaction of LANA with both the viral episomes and the host metaphase chromosomes. ...
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Impact of mesenchymal stem cells’ secretome on glioblastoma pathophysiology
... in multiple dimensions of GBM cell biology, the sensi- tivity of these tumor cells to TMZ chemotherapy was not significantly affected by HUCPVCs CM (Fig. 3b, d). These results are in agreement with the work of Onzi and ...
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Antimicrobial titanium/silver PVD coatings on titanium
... The surface roughness was measured with a profilometer Surftest 211 (Mitutoyo, Japan); 3 measurements were car- ried out at various positions on the surface, the average and the standard deviation were calculated. The ...
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Discovery of a New Family of Protein Kinases Containing Phosphoinositide 3/4-Kinase and Ubiquitin-Like Domains
... unfolded protein response (UPR) in Arabidopsis thaliana. UbDKγ4 encodes a protein (Ser/Thr) kinase originally identified as a putative type II phosphatidylinositol ...controlled protein degradation ...
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A systematic study of palmitoylation using the model organism Caenorhabditis elegans
... Protein PREDICTED: coiled-coil and C2 domain-containing protein 2A-like T-complex protein 1 subunit β cell division control protein 42 isoform 1 centrin 4 chromodomain helicase DNA-bindi[r] ...
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Bromodomain protein inhibition: a novel therapeutic strategy in rheumatic diseases
... by bromodomain (BRD) proteins is a key event in transcriptional ...targeting bromodomain and extra-terminal (BeT) proteins compete for binding to acetylated ...
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The first bromodomain of Brdt, a testis specific member of the BET sub family of double bromodomain containing proteins, is essential for male germ cell differentiation
... The bromodomain is an evolutionarily conserved motif first identified in the Drosophila genes brahma and female sterile (1) homeotic [fs(1)h] (Haynes et ...encoding bromodomain-containing proteins ...
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