C- and N-terminal interaction
The N Terminus of Rift Valley Fever Virus Nucleoprotein Is Essential for Dimerization
... head-to-tail interaction forming a multimeric chain ...the N protein present in viral RNPs or expressed as a recombinant protein in Escherichia coli assembles into dimers and trimers, the latter being the ...
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The N-terminal region of Fibrillin-1 mediates a bipartite interaction with LTBP1
... (B) Model of LAP and fibrillin binding of LTBP1S constructed using the program Modeller and co- ordinate files PDB: 1UZJ, 1EMN, and 1KSQ. LTBP1 atoms are represented as spheres colored by domain as in Figure 1, while ...
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Distinct Mechanism for the Formation of the Ribonucleoprotein Complex of Tomato Spotted Wilt Virus
... TSWV N to determine its biological function and biochemical ...TSWV N for multimerization showed that both the N-terminal end (amino acids 1 to 39) and the C-terminal end (amino ...
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Autophagic Flux is Regulated by Interaction Between the C-terminal Domain of Patched1 and ATG101
... Kraft C, Ktistakis NT, Kumar S, Levine B, Lopez-Otin C, Madeo F, Martens S, Martinez J, Melendez A, Mizushima N, Münz C, Murphy LO, Penninger JM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan ...
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Thesis
... seventh N-terminal HEAT repeat (HR) that binds orthogonal to HRs ...the N-terminal HR facilitates lateral tubulin interactions; however, its function is still at large ...the ...
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Insights into Chibby's structural elements and their interplay in Wnt signaling protein-protein interactions
... unstructured N-terminus and contains a coiled-coil motif within its C-terminus (residues 73-100) that enables dimerization ...its C-terminus to bind to β -catenin [1], although residues critical for ...
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Contrasting Function of Structured N Terminal and Unstructured C Terminal Segments of Mycobacterium tuberculosis PPE37 Protein
... Although genome sequence data (11) and expression profiles of virulent, avirulent, and clinical M. tuberculosis strains have contributed to a better understanding of its infection biology, not much is known about the ...
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Differential Contributions of Tacaribe Arenavirus Nucleoprotein N-Terminal and C-Terminal Residues to Nucleocapsid Functional Activity
... the C-terminal residue D471, which is strictly con- served across the Arenaviridae, has been recently reported to be essential for homo-oligomerization of LCMV NP (40), we next FIG 2 Identification of amino ...
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The N Terminus and C Terminus of Herpes Simplex Virus 1 ICP4 Cooperate To Activate Viral Gene Expression
... the N-ter- minal 200 amino acids is involved in interactions with multiple transcription ...conserved C-terminal region (amino acids 774 to 1294) “augments” the ac- tivities of the N terminus ...
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Structural Role of S100 Proteins in Membrane Repair
... the C-terminal domain of AHNAK (De Seranno et ...of N-terminus of annexin A2 upon calcium binding to the protein core domain allowing formation of the heterotetramer and subsequent recruitment of ...
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Interaction of the C-Terminal Domains of Sendai Virus N and P Proteins: Comparison of Polymerase-Nucleocapsid Interactions within the Paramyxovirus Family
... Sendai virus (SeV) was discovered in 1952 (26) and is also referred to as murine parainfluenza virus as it was found to infect the respiratory tract of mice, to cause pneumonia, and to readily spread to uninfected ...
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The Monothiol Glutaredoxin Grx4 Exerts an Iron-Dependent Inhibitory Effect on Php4 Function
... In the model organism Schizosaccharomyces pombe, the GATA- type transcription factor Fep1 binds to chromatin and represses the expression of a number of genes involved in iron acquisition when the intracellular iron ...
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Crystal Structure of the Oligomerization Domain of the Phosphoprotein of Vesicular Stomatitis Virus
... the C ter- minus of the central ...the C-terminal domain to the central ...helix-helix interaction in the ...the N-terminal and C-terminal domains for their func- ...
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Functional analysis of the global repressor Tup1 for maltose metabolism in Saccharomyces cerevisiae: different roles of the functional domains
... protein–protein interaction domains: the first 72 amino acids, the C-terminal seven WD repeats (340– 713 amino acids), and the middle region in ...The N-terminal region of 72 amino ...
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A structural constraint for functional interaction between N terminal and C terminal domains in simian immunodeficiency virus capsid proteins
... Japan). Viral titers were measured by reverse transcrip- tion (RT) assay as described previously [46]. For analysis of viral replication kinetics, HSC-F cells (herpesvirus sai- miri-immortalized macaque T-cell line) [47] ...
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NS4B Self-Interaction through Conserved C-Terminal Elements Is Required for the Establishment of Functional Hepatitis C Virus Replication Complexes
... two C-terminal NS4B fragments (homotypic interactions) or by interactions between two different protein fragments such as an N-terminal and a C-terminal NS4B frag- ment ...
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Citrus Psorosis Virus Movement Protein Contains an Aspartic Protease Required for Autocleavage and the Formation of Tubule-Like Structures at Plasmodesmata
... the tubule assembly from MP, the monomers of the tubule-forming MPs of caulimo- and nepoviruses showed MP-MP interactions in vivo (27). Moreover, these proteins were shown to interact with members of the PDLP family at ...
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Molecular Population Genetics and Evolution of a Prion-like Protein in Saccharomyces cerevisiae
... tion. The average amino acid replacement is under weak Poly, number of polymorphic sites in S. cerevisiae; Div, num- purifying selection across the two regions, with stronger ber of fixed sites differing from homologue ...
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Presenilins and the γ-secretase: still a complex problem
... APP mutations on chromosome 21 account for only a small fraction of the total number of FAD cases. It was clear that multiple FAD loci existed on other chromo- somes. The first evidence for an FAD locus on chromo- some ...
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Transformation of avian fibroblasts overexpressing the c-rel proto-oncogene and a variant of c-rel lacking 40 C-terminal amino acids.
... Cytoplasmic localization could be due to interaction with IKB molecules, and in fact, the overexpression of c-Rel or the C-terminal deletion construct of c-Rel resulted in an increase in[r] ...
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