C, complement
Hepatic inflammation mediated by hepatitis C virus core protein is ameliorated by blocking complement activation
... the complement pathway in human hepatitis C; indeed, plasma C3 has been proposed as a marker for activity in this disease ...the complement cas- cade, has been identified as conferring susceptibility ...
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Complement is dispensable for neurodegeneration in Niemann-Pick disease type C
... and complement component expression is increasingly elevated with age in NPC ...and c, ...the complement cascade for Npc1 -/- mice compared to wild-type, Npc1 +/- or Npc1 +/+ , mice are shown at two ...
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SERUM LEVELS OF C-REACTIVE PROTEIN, COMPLEMENT 3 AND COMPLEMENT 4 IN IRAQI DIABETIC PATIENTS ON METFORMIN THERAPY
... of C-reactive protein (CRP), an inflammatory biomarker in diabetic ...7,8,9 C-reactive protein is presented as a pentameric protein circulated in blood; this mediator increased in response to infection and ...
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In vivo metabolism of complement: I Metabolism of the third component (C′3) in acquired hemolytic anemia
... of complement labeled with 125 -iodine (C¢3- 125 I) was studied in normal subjects and in patients with acquired hemolytic ...using C¢3i, the biologically inactive reaction product of ...
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Fixation of the first component of complement (C′1a) by human antibodies
... Antibodies of the Rh system do not fix significant amounts of C¢1a in the absence of anti- antibody when antiserum of a single Rh specificity was used. However, when three antisera at different specificity are ...
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Inherited deficiency of the third component of human complement (C′3)
... A kindred has been investigated in which seven individuals were found to have half-normal serum concentrations of the third component of complement (C¢3). This partial deficiency was transmitted as an ...
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Hepatitis C Virus Suppresses C9 Complement Synthesis and Impairs Membrane Attack Complex Function
... various complement-related diseases ...the complement C9 gene is common in individuals in Japan with C9 deficiency, and the lack of the mem- brane attack complex due to this mutation predisposed patients to ...
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Transcriptional Repression of C4 Complement by Hepatitis C Virus Proteins
... The complement system is a set of biochemical pathways that helps to clear pathogens from an organism as part of the innate and acquired immunity ...the complement system triggers a wide range of cellular ...
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Hepatitis C Virus Impairs Natural Killer Cell-Mediated Augmentation of Complement Synthesis
... the complement system play critical roles in the first line of defense against ...of complement components C4 and C3 is transcriptionally downregulated by hepatitis C virus (HCV) core and NS5A pro- ...
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Hepatitis C Virus Proteins Inhibit C3 Complement Production
... human complement (C3) plays a central role in innate immune function as its activation is required to trigger classical as well as alternative complement ...hepatitis C virus (HCV) displayed ...
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Type C retrovirus inactivation by human complement is determined by both the viral genome and the producer cell.
... Viral infection of the cell lines did not affect their sensitivity; in particular, infection of Mv-1-Lu or HOS cells with MLV-A or MLV-X did not render them sensitive to lysis by human s[r] ...
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Complement component 3 (C3) expression in the hippocampus after excitotoxic injury: role of C/EBPβ
... The complement pathway is an essential regulator of the immune response, including chemotaxis, phago- cytosis, cell adhesion, and B and T cell differentiation [22, 23], and it is a very important line of defense ...
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Diagnostic performance of serum cystatin C and complement component 1q in lupus nephritis
... The role and clinical relevance of the serum C1q levels in the renal involvement in LN patients still need to be elucidated. Our findings showed that the levels of C1q were significantly lower in the SLE, LNA, and LNI ...
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Relationships between alternative complement pathway activation, C reactive protein, and pneumococcal infection
... Student's t test was used to examine the effects of patient classification factors complicated versus uncomplicated, bacteremia versus abacteremia, serotype numerically higher versus low[r] ...
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Derivation of ligands for the complement C3a receptor from the C-terminus of C5a
... the C termini, as well as a conserved Tyrosine (Y) two amino acids before the LWR ...the C termini in the superagonist ‘W -W-G-K-K-Y-R-A-S-K-L-G-L-A- R’ (Bellows-Peterson et ...the C terminus ...
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Genetic polymorphism of the third component of human complement (C′3)
... The allotypes appear to differ in net surface charge at pH 8.6, but show no obvious differences in complement activity, in molecular size, or in binding of Ca ++ . The concentrations of the two gene products in ...
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Hereditary deficiency of the second component of complement (C'2) in man
... The hemolytic, bactericidal, and immune adherence activities of C'2 deficient serum were fully restored upon the addition of highly purified human C'2.5 These observations suggest that t[r] ...
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Action of Complement in Hereditary Angioneurotic Edema: The Role of C′1 Esterase
... The increased amounts of C'1-esterase activity in serum and plasma of patients having attacks of swelling or pain suggested that C'1-esterase might have caused increased vascular permeab[r] ...
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Species Specificity of Vaccinia Virus Complement Control Protein for the Bovine Classical Pathway Is Governed Primarily by Direct Interaction of Its Acidic Residues with Factor I
... FIG 10 Sequence alignment of poxviral complement regulators. The protein sequences of CCP domains 2 and 3 of VCP and VCP orthologs from various poxviruses were aligned using Clustal Omega (version 1.2.3). The ...
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Complement receptor 2–mediated targeting of complement inhibitors to sites of complement activation
... the C terminus (DAF-CR2 and CD59-CR2) showed slow association and dissociation rates (Figure 4 and Table ...than C-terminal coun- terparts, flow cytometry indicated that a larger amount of the ...
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