c-Jun
C Jun N terminal kinases/c Jun and p38 pathways cooperate in ceramide induced neuronal apoptosis
... To further investigate the specific role of the JNK/c-Jun pathway in ceramide-induced cortical neuron apoptosis, we overexpressed a DNc-Jun in primary cortical neurons. Our results demonstrate that ...
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DYRK2 priming phosphorylation of c Jun and c Myc modulates cell cycle progression in human cancer cells
... analyzed by immunoblotting with anti–phospho–c-Jun(Ser243) (left upper panel), anti–phospho–c-Myc(Ser62) (right upper panel), anti-His (middle panels), or anti-GST (lower panels). (C) 293T ...
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Vaccinia Virus B1R Kinase Interacts with JIP1 and Modulates c-Jun-Dependent Signaling
... and c-Jun activation have been ...as c-Jun, that respond to these ...phosphorylate c-Jun in residues different from those targeted by JNK and, thus, B1R can also cooperate by an ...
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Original Article Brain edema and protein expression of c-Fos and c-Jun in the brain after diffused brain injury
... At corresponding time points, animals were intraperitoneally anesthetized with 1% sodium pentobarbital at 30 mg/kg. The chest cavity was opened, and perfusion was transcardially done with normal saline for 10 min and ...
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Induction of the RelB NF-κB Subunit by the Cytomegalovirus IE1 Protein Is Mediated via Jun Kinase and c-Jun/Fra-2 AP-1 Complexes
... Cytomegalovirus (CMV) is a betaherpesvirus that latently infects a majority of adults worldwide (24). Although most healthy immunocompetent individuals are asymptomatic (6), enhanced risk of atherosclerosis and ...
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c-JUN prevents methylation of p16 INK4a (and Cdk6): the villain turned bodyguard
... Besides c-JUN’s “survival” function in interfering with p53 induced apoptosis, c-JUN has been shown to drive cell ...and c-JUN’s ability to effect this represents a further way in which the ...
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SPANXA suppresses EMT by inhibiting c-JUN/SNAI2 signaling in lung adenocarcinoma
... And c-JUN is responsible for SNAI2 expression and EMT suppression. c-JUN is a basic region-leucine zipper protein belonging to one member of the AP-1 ...of c-JUN and c-FOS ...
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Reovirus Infection Activates JNK and the JNK-Dependent Transcription Factor c-Jun
... Western Blot analysis and antibodies. Following infection with reovirus, cells were pelleted by centrifugation, washed twice with ice-cold phosphate-buffered saline, and lysed by sonication in 200 l of a buffer ...
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Elevated DDX21 regulates c Jun activity and rRNA processing in human breast cancers
... of c-Jun did not appear to regulate the nuclear localization of DDX21, since in MDA-MB-231 cells that had the highest c-Jun levels, DDX21 predomin- antly localized to the ...the ...
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C/EBP and c JUN proteins activate the proximal enhancer of the developmentally regulated alpha fetoprotein gene
... Int J On mol J6 1I)9 11~ (1992) 109 C/EBP and c JUN proteins activate the proximal enhancer of the developmentally regulated a fetoprotein gene CORINNE HOUART, JOSIANE SZPIRER and CLAUDE SZPIRER* Univ[.] ...
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Critical roles of c Jun signaling in regulation of NFAT family and RANKL regulated osteoclast differentiation
... of sRANKL (25). These findings provided evidence that NFAT2 is an important transcription factor for osteoclast formation. To advance these previous studies, we investigated the molecular basis by which NFAT regulates ...
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Pentraxin-2 suppresses c-Jun/AP-1 signaling to inhibit progressive fibrotic disease
... as C/ EBPβ, TRAF6, and MyD88 (Supplemental Table ...near c-Jun and ringed with other transcription factors that either are also AP-1 family members (Jun-B, Fosl2) or form transcriptional ...
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Modulation of c Jun NH2 Terminal (JNK) by Cholinergic Autoantibodies from Patients with Sjögren’s Syndrome
... ABSTRACT Background: We wanted to determine via an immunopharmacological approach whether the c-Jun NH2 terminal kinase JNK cascade is phosphorylated in the submandibular gland by carbac[r] ...
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Inhibition of c Jun N terminal kinase (JNK) suppresses porcine oocyte ageing in vitro
... ABSTRACT: Oocyte ageing is a complex of processes that occur when matured in vitro oocytes are, after rea- ching the metaphase II stage, exposed to further in vitro culture. Aged oocytes remaining at the metaphase II ...
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Overexpression of MAPK15 in gastric cancer is associated with copy number gain and contributes to the stability of c-Jun
... Total proteins were extracted from the cultured cells using a lysis buffer containing Protease Inhibitor Cocktail (Roche Applied Science, Indianapolis, IN). The lysates were heated to 95°C for 5 min, loaded on 10% ...
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c Jun N terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
... JNK inhibition also decreased the induction of AP-1 DNA-binding activity in synoviocytes, which is prima- rily dependent on new Jun and Fos protein synthesis in synovial fibroblasts. Of particular interest, ...
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c Jun N terminal kinase activation by nitrobenzoxadiazoles leads to late stage autophagy inhibition
... NBDHEX (6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio) hexan-1-ol) is the leading compound of a class of nitrobenzoxadiazole derivatives (NBDs) with promising anticancer properties. Indeed, by targeting ...
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Poliovirus Induces Bax-Dependent Cell Death Mediated by c-Jun NH2-Terminal Kinase
... anti-cytochrome c (C5723) and mouse anti- actin (A3853) antibodies, staurosporine (STS) (S4400), phosphatase inhibitor cocktail (P2850), and protein G (P3296) were obtained from ...
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Transcriptional regulation of c jun gene expression by arabinofuranosylcytosine in human myeloid leukemia cells
... of c-jun transcripts in ara-C-treated KG-1 cells was 42 ...in c-jun mRNA observed during ara-C treatment is regulated by a transcriptional mechanism, and that c-jun ...
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Cop1 constitutively regulates c Jun protein stability and functions as a tumor suppressor in mice
... oncoprotein c-Jun and the tumor suppressor p53 as its ...that c-Jun was a key physiological target for Cop1 and that Cop1 constitutively kept c-Jun at low levels in vivo and ...
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