c-kit
Original Article Membrane estrogen receptor alpha is an important modulator of bone marrow C-Kit cells mediated cardiac repair after myocardial infarction
... Total RNAs were extracted using TRIzol (RiboPure kit, Ambion, AM1924) following the manufacturer’s instruction. One microgram of total RNA per 20 μl of reaction volume was reverse transcribed into cDNA using the ...
15
Screening of candidate G-quadruplex ligands for the human c-KIT promotorial region and their effects in multiple in-vitro models
... on c-KIT expression and its mutational status [32, ...to c-KIT ...on c-KIT, showed a high sensitivity to AQ1 while the prostate cancer cell line PC3 did ...to c-KIT ...
18
Expression and localisation of c-kit and KITL in the adult human ovary
... of c-kit staining ap- peared no different in the two PCOS ovaries compared to non-PCOS, it was observed that oocytes in preantral follicles of PCOS patients more consistently exhibited strong oolemma ...
12
c KIT expression enhances the leukemogenic potential of 32D cells
... independent. This model illustrates that the constitutive expression of c-Kit enhances the leukemic potential of 32D cells. The model will be useful for studying the progression of leukemia in vivo and ...
10
miR199a-3p regulates P53 by targeting CABLES1 in mouse cardiac c-kit+ cells to promote proliferation and inhibit apoptosis through a negative feedback loop
... The effective RNAi sequence targeting the CABLES1 gene was designed and screened at the Shanghai Bioladder Corporation (Shanghai, China). We selected sequences as target sequences for CABLES1: ShRNA-CABLES1: 5’- ...
13
Original Article Gastrointestinal stromal tumors with exon 8 c- kit gene mutation might occur at extragastric sites and have metastasis-prone nature
... for KIT and PDGFRA [24], which is clinically used for treat- ment of metastatic or unresectable GISTs ...the c-kit and PDGFRA gene mutations [26, ...11 c-kit gene mutations show best ...
8
Pim1 kinase regulates c-Kit gene translation
... new c-Kit protein synthesis via enhanced ...on c-Kit gene trans- lation, we fractioned ribosomes of HEK293 T cells transduced with control lentiviral vector (Fu-Ctl) or Pim1 overexpressing ...
8
Role of C-Kit Receptor Tyrosine Kinase on INS-1 Cell VEGF-A Expression in Vitro
... 1996). c-Kit mRNA is found at detectable levels by embryonic day 13 in the rat pancreatic epithelial cells (Oberg-Welsh et ...that c-Kit-expressing human and rat fetal pancreatic ductal ...
132
Gene Expression Profiling of Human c Kit Mutant D816V
... Wild-type and mutant D816V-c-Kit were stimulated with and without huSCF (100 ng/ml) for 24 hrs. Cells were lysed in an appropriate amount of RIPA lysis buffer (50 mM Tris-HCl, pH 7.4, 150 mM sodium ...
16
Original Article C-kit expression in human osteosarcoma and in vitro assays
... investigate c-kit immunoexpression, its prognostic relevance for patients with osteosarcoma, and the effect of imatinib mesylate (STI571) on proliferation and invasion of the human osteosarcoma cell ...
7
Original Article The effects of the combination of imatinib and crizotinib on small cell lung cancer cells expressing c-Met and c-Kit
... of c-Kit and that crizotinib acts as an inhibitor of ALK, c-Met and RON ...that c-Kit and c-Met are highly expressed in ...of c-Met and ...
9
Using c kit to genetically target cerebellar molecular layer interneurons in adult mice
... endogenous c-kit gene expression ...of c-kit (c-kit CreERT2 ) has been engineered allowing for inducible control of Cre activation following administration of tamoxifen [43, ...
17
An anticancer C Kit kinase inhibitor is reengineered to make it more active and less cardiotoxic
... As C-Kit associates with imatinib, the loop fac- ing the para-position on the terminal ring (Figure 1B and Figure 3A) was found to be ...the C-Kit complex, the same loop was found to be ...
12
C-kit receptor immunopositive interstitial cells (Cajal-type) in the porcine reproductive tract
... The specificity of immunoreactions was confirmed in the positive control—porcine ileum used as reference material and the negative control—lack of signal. We confirmed similar immunophenotypes of ICC and ICLC in porcine ...
9
Comparison of c-Kit expression between primary and metastatic melanoma of skin and mucosa
... for KIT was performed using an anti-CD117 polyclonal rabbit an- tihuman antibody (Dilution 1:1000, Dako- Cytomation, Carpinteria, CA, USA) on tis- sue ...positive c-Kit GIST were used as positive ...
6
The C-Kit Receptor-Mediated Signal Transduction and Tumor-Related Diseases
... Human c-kit receptor loss of function mutations can cause autosomal mottle disease ...to c-kit receptor ...sustained c-kit receptor activation ...of c-kit receptor ...
9
The clinicopathologic observation, c-KIT gene mutation and clonal status of gastrointestinal stromal tumor in the sacrum
... the c-KIT gene showed that the c-KIT gene mutation occurred in exon 11, but not in other domains investigated (exon 9, 13 and 17), in support of a diagnosis of GIST in this ...of KIT ...
6
c KIT receptor expression is strictly associated with the biological behaviour of thyroid nodules
... for c-KIT in thyroid malignancies suggested to perform an analysis of c-KIT expression on thyroid cells obtained by FNAC from benign and malignant thyroid nodules, with the double aim to study ...
9
RanBPM (RanBP9) regulates mouse c-Kit receptor level and is essential for normal development of bone marrow progenitor cells
... of c-Kit protein levels in the RanBPM mutants had an effect on SCF signaling we dissociated P9 testicular cells from mutant and wild type littermates and stimulated them with SCF (Figure ...2C). ...
15
Original Article C-kit and PDGFRA gene mutations in triple negative breast cancer
... evaluated C-kit immunohistochemical expression and C-kit and platelet derived growth factor receptor A (PDGFRA) gene mutations in triple negative breast ...of C-kit and 45 cases, ...
6