c-MYC gene
Structure and transforming function of transduced mutant alleles of the chicken c-myc gene.
... Interestingly, the comparison between the transforming activities of MH2E21 and MH2E21m1 or between those of MH2E21cl and MH2E21m1c1 revealed that the presence of additional amino-termin[r] ...
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Premature termination of transcription of the murine c-myc gene
... the c - m y c ...n c y with w hich elo ngation- or te rm in a tio n -c o m p e te n t initiation com plexes can be ...human c - m y c terminator in the absence of a promoter ...
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Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 (vIRF4) Targets Expression of Cellular IRF4 and the Myc Gene To Facilitate Lytic Replication
... instance, c-Myc overexpression as a consequence of reciprocal translocation to the immunoglobulin loci has been found in various B-cell lympho- mas ...any c-Myc mutations or its locus ...
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Small Molecules Targeting c-Myc Oncogene: Promising Anti-Cancer Therapeutics
... transcribe c-Myc gene, and in contrast, the silenced form, containing G-quadruplexes, prevents the various transcription factors from interacting with the element, leading to a down-regulation of ...
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CDK5 neutralizes the tumor suppressing effect of BIN1 via mediating phosphorylation of c-MYC at Ser-62 site in NSCLC
... prognosis. c-MYC, a key transcription factor by bind- ing on enhancer box sequences (E-boxes), is frequently dysregulated and acts as a tumor promoting protein in numerous cancers [3, ...4]. ...
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Development of human gene reporter cell lines using rAAV mediated homologous recombination
... deregulated c-Myc expression is thought to be due to oncogenic activation of mitogenic signal transduction pathways that regulate c-Myc gene expression (15, 16, ...the ...
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Correlation of HER2, MDM2, c-MYC, c-MET, and TP53 Copy Number Alterations in Circulating Tumor Cells with Tissue in Gastric Cancer Patients: A Pilot Study
... of c-MYC may play a role in the tumorigeneses process of GC, and its deregulation is associated with the poor prognostic features of GC patients [26,27] ...of c- MYC deregulation in GC [28] . ...
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Changes in the phenotype of human small cell lung cancer cell lines after transfection and expression of the c myc proto oncogene
... immunoreactivity. C-myc is amplified and expressed in some small cell lung cancer cell lines and all c-myc amplified lines studied to date display the variant ...if c-myc ...
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Transcription factor FoxM1 is the downstream target of c Myc and contributes to the development of prostate cancer
... the MYC gene family, is involved in regulating a lot of biological activities ...on, c- Myc has been found overexpressed in colon cancer, breast cancer, lung cancer, and prostate cancer ...
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Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype.
... core gene construct with or without the plasmid DNA containing the oncogenes by a procedure similar to that described earlier ...core gene (1 m g) was transfected with or without 1 m g of the H-ras ...
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Brief inactivation of c Myc is not sufficient for sustained regression of c Myc induced tumours of pancreatic islets and skin epidermis
... inactivating c-Myc transiently in two distinct tumour types in ...re-activating c-Myc in islet β-cell tumours does not lead to accelerated β-cell apoptosis, but rather restores the oncogenic ...
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Postnatal liver growth and regeneration are independent of c-myc in a mouse model of conditional hepatic c-myc deletion
... the c-myc/max/mad network We went on to explore whether the lack of an effect of reducing c-myc on hepatocyte proliferation, growth, and protein synthesis could be accounted for by compensa- ...
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BCYRN1, a c-MYC-activated long non-coding RNA, regulates cell metastasis of non-small-cell lung cancer
... containing c-MYC-specific shRNA (shRNA- c-MYC) was used for the inhibition of c-MYC ...The c-MYC-targeting sequence was composed of the nu- cleotides from 1567 to ...
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The role of c-Myc-RBM38 loop in the growth suppression in breast cancer
... by c-Myc knockdown in breast cancer ...that c-Myc binds directly to the presumed c-Myc binding site (E-box) in the RBM38 promotor ...following c-Myc knockdown in ...
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FGFR1 is amplified during the progression of in situto invasive breast carcinoma
... of gene amplification in the progression of DCIS to invasive breast cancer is ...in gene amplification frequencies between DCIS and invasive carcinomas ...that C-MYC amplification plays an ...
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The Notch target gene hairy2a impedes the involution of notochordal cells by promoting floor plate fates in Xenopus embryos
... In order to determine whether hairy2a is a target of Notch in the DML precursors, we activated or prevented Notch signalling with notch ICD or su(H) DBM mRNA, respectively, and analysed the expression of hairy2a. To ...
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Original Article Expression of c-Myc and Fas correlates with perineural invasion of pancreatic cancer
... of c-Myc and Fas was assessed according to the percentage of staining as follows: 1, 0 points for no staining; 2, 1 point for < 20%; 3, 2 points for 20-75%; 4, 3 points for > 75% of cancer tissue ...
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The Role of Corrective Gene Therapy Targeting the C-myc Oncogene in Melanoma
... bcl-2 gene is overexpressed in metastatic melanoma and its expression level is an accurate prognostic marker for advanced disease (Grover et ...bcl-Xg gene, an inhibitor o f the bcl-2 gene, has been ...
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Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer
... suppresses c-Myc expression through miRNA-mediated inhibition [36] or post- translational modification [37], we show that metformin reduces c-Myc expression in ovarian cancer specifically ...
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Hoelzel, Michael (2004): Regulation von Teilungswahrscheinlichkeit und Zellzyklusdauer durch das Onkoprotein c-Myc. Dissertation, LMU München: Medizinische Fakultät
... Für die Zellen der F0 Generation erscheint dieses Verfahren noch recht praktikabel, weil ihre Beobachtung zu einem gemeinsamen Zeitpunkt beginnt. Zellen der Tochtergenerationen entstehen aber zu unterschiedlichen ...
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