C-terminal binding protein 2
PPARGC1α gene DNA methylation variations in human placenta mediate the link between maternal hyperglycemia and leptin levels in newborns
... domain-containing protein 16 ( PRDM16 ) transcription factor that triggers the activation of the brown adipo- genic ...the C- terminal binding protein 2 ( CTBP2 ) transcriptional ...
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Surf the Post-translational Modification Network of p53 Regulation
... CREB binding protein (CBP)/p300 (specific enzymes for the acetylation of p53) and p53 form a ternary complex in unstressed cell, and phosphorylation of S15, T18 and S20 increase p53‘s affinity for CBP/p300 ...
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APOL1 variants change C-terminal conformational dynamics and binding to SNARE protein VAMP8
... Immunohistochemistry, immunofluorescence, and immunocytochemistry. Immunohistology was performed as previously described (12); details are available in the Supplemental Methods. Briefly, human kidney tis- sue was ...
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Specific interaction of polypyrimidine tract-binding protein with the extreme 3'-terminal structure of the hepatitis C virus genome, the 3'X.
... RNA-binding protein bands were not reduced by additional tRNA (Fig. 2, lane ...(Fig. 2, lanes 3 to ...57-kDa protein which specifically interacted with the 3 9 -end region of HCV RNA ...
7
Structure-Function Analysis of Vaccinia Virus H7 Protein Reveals a Novel Phosphoinositide Binding Fold Essential for Poxvirus Replication
... H7 protein. Recombinant H7 protein was expressed and purified from ...H7 protein with a cysteine-to-serine sub- stitution at residue 89 (H7-C89S) yielded crystals of higher qual- ity, which gave rise ...
11
C-Terminal Arginine Cluster Is Essential for Receptor Binding of Norovirus Capsid Protein
... protein was seen (Fig. 5A). Mass spectrometry analysis showed that these trypsin-released P polypeptides had an apparent molecular mass of 31.3 kDa (Fig. 5C; Table 3), indicating that trypsin also cleaved at the ...
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Membrane Binding Properties and Terminal Residues of the Mature Hepatitis C Virus Capsid Protein in Insect Cells
... core protein indicated that the majority of p21 associates with P10 membranes ...core protein is associated with mitochondria (37), it is possible that a portion of p21 in the P10 fraction is associated ...
12
Redox Potential Regulates Binding of Universal Minicircle Sequence Binding Protein at the Kinetoplast DNA Replication Origin
... DNA binding of N-terminal deleted UMSBP is insensitive to the redox ...the C-terminal DNA-binding domain or, alternatively, acts indirectly through its effect on the pro- tein ...mutant ...
12
Multiple roles and therapeutic implications of Akt signaling in cancer
... 4E-binding protein 1; AGC, protein kinase A/protein kinase G/protein kinase C-like; Bcl-2, B-cell lymphoma 2; CAP, catabolite activator protein; CTMP, ...
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<p>C-terminal of E1A binding protein 1 enhances the migration of gastric epithelial cells and has a clinicopathologic significance in human gastric carcinoma</p>
... fi c mortality ...resection. 2 As the increasing detection of early GC, biological therapy options have been technologically advanced both curatively and mini- mally invasively to maintain a good quality of ...
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Effects of an Early Conformational Switch Defect during ϕX174 Morphogenesis Are Belatedly Manifested Late in the Assembly Pathway
... a C-terminal aromatic amino acid results in a lethal ...scaffolding protein residues D111 and E113 form respective salt bridges with coat protein residues R239 and ...B protein ...
8
Important roles of C terminal residues in degradation of capsid protein of classical swine fever virus
... that C-EGFP protein expressed at a low level and decreased over time, we assume that C-EGFP protein might be degraded after ...cleaved C-EGFP in PK-15 and 3-MA had no effect on ...
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Resequencing at >=40 fold depth of the parental genomes of a Solanum Lycopersicum x S pimpinellifolium recombinant inbred line population and characterization of frame shift indels that are highly likely to perturb protein function
... ure 2), which was much higher than the typical 1000 mutations per Mb in ...(Figure 2, Figure S3, and Figure S4); the similar positions and identities of poly- morphisms in these two regions suggests an ...
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Structural and functional characterization of bacterial response and neuroprotective proteins
... protocols used simulated annealing with torsion angle and Cartesian space dynamics using the default parameters. Manually assigned inter- and intramolecular NOE’s were input to ARIA as assigned and uncalibrated with ...
225
The MDM2 Oncoprotein Binds Specifically to RNA through its RING Finger Domain
... The MDM2 protein was initially tested to deter- mine if it was capable of binding to RNA because of the presence of the central zinc finger and C-terminal RING finger domains in the prot[r] ...
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Silver nanoparticles embedded in zeolite membranes: release of silver ions and mechanism of antibacterial action
... Ltd, Tokyo, Japan), with an average particle size of 300 nm, silastic T-2 polydimethylsiloxane (Dow Corning, Midland, MI), 200 proof ethyl alcohol (Pharmco, Brookfiled, CT), and 1-octanol (Puriss, Fluka, Buchs, ...
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The 60-Residue C-Terminal Region of the Single-Stranded DNA Binding Protein of Herpes Simplex Virus Type 1 Is Required for Cooperative DNA Binding
... the C-terminal portion of the molecule contains glycine- and pro- line-rich motifs as well as several polar ...for binding, and it was not clear how and to what extent further deletion could affect ...
11
Nanopores: maltoporin channel as a sensor for maltodextrin and lambda-phage
... In a second series of experiments we were interested to probe for Lambda phage binding. In principle this should be possible despite the enormous size (about 100 nm size in comparison to 4 nm sized channels). ...
6
The N- and C-Terminal Domains of the NS1 Protein of Influenza B Virus Can Independently Inhibit IRF-3 and Beta Interferon Promoter Activation
... of protein kinase R in vitro. A critical function of the A/NS1 protein is the inhibition of synthesis of alpha/beta interferon (IFN- ␣ /  ) during viral ...B/NS1 protein inhibits IFN- ␣ /  ...
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Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments
... TDP-43 C-terminal fragments form cytoplasmic aggregates and cause cyto- toxicity [3-6]; thus, TDP-43 truncation may play an important role in the pathogenesis of ALS, FTLD-U and other TDP-43 ...the ...
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