Ca2+ calmodulin
Release from the metaphase I block in invertebrate oocytes: possible involvement of Ca2+/calmodulin dependent kinase III
... Int J De\ IIi,,! 37 279 290 (1993) 279 Original Article Release from the metaphase I block in invertebrate oocytes possible involvement of Ca2+/calmodulin dependent kinase III HAYA ABDELMAJID,,4, CATH[.] ...
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Elevated intracellular Ca2+ acts through protein kinase C to regulate rabbit ileal NaCl absorption Evidence for sequential control by Ca2+/calmodulin and protein kinase C
... intracellular Ca2+ affects Na and Cl transport is ...the Ca2+/calmodulin and protein kinase C systems in ileal NaCl transport, two drugs, the isoquinolenesulfonamide, H-7, and the ...
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The Role of Ca2+/Calmodulin Dependent Protein Kinase II Alpha in Group 1 Metabotropic Glutamate Receptor Endocytosis and Signalling
... Ca 2+ /calmodulin. Results from a proteomic screen identified CaMKII as a novel mGluR- interacting protein. Therefore, we hypothesized that CaMKIIα associates with group 1 mGluRs and this association alters ...
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Investigation of neuronal cell type-specific gene expression of Ca2+/calmodulin-dependent protein kinase II
... Ca 2+ /calmodulin-dependent protein kinase II (CaM kinase II) is one of the most abundant protein kinases in mammalian brain and a major mediator of calcium signaling in neurons. CaM kinase II is involved in ...
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The Ca2+-Calmodulin-Activated Protein Phosphatase Calcineurin Negatively Regulates Egf Receptor Signaling in Drosophila Development
... screen in the Drosophila eye using an activated form of the catalytic subunit to identify new targets, regulators, and functions of calcineurin. An examination of 70,000 mutagenized flies yielded nine specific ...
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Regulation of Metabotropic Glutamate Receptor 5 activity by Ca2+/Calmodulin-dependent Protein Kinase IIα
... Phosphorylationindependent regulation of metabotropic glutamate receptor 1 signaling requires g proteincoupled receptor kinase 2 binding to the second intracellular loop. G Prote[r] ...
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Ca2+/calmodulin dependent protein kinase II regulates cardiac Na+ channels
... In heart failure (HF), Ca 2+ /calmodulin kinase II (CaMKII) expression is increased. Altered Na + channel gating is linked to and may promote ventricular tachyarrhythmias (VTs) in HF. Calmodulin regulates ...
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Molecular basis for the modulation of native T type Ca2+ channels in vivo by Ca2+ /calmodulin dependent protein kinase II
... Ang II receptor activation increases cytosolic Ca 2+ levels to enhance the synthesis and secretion of aldosterone, a recently identified early pathogenic stimulus that adversely influences cardiovascular homeostasis. Ca ...
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Herbal formula GAPT prevents beta amyloid deposition induced Ca2+/Calmodulin dependent protein kinase II and Ca2+/Calmodulin dependent protein phosphatase 2B imbalance in APPV717I mice
... Calcineurin (CaN), also known as protein phosphatase 2B (PP2B), is a calmodulin-dependent serine/threonine phosphatase physiologically activated by Ca 2+ . It is also highly expressed in the central nervous system ...
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Altered regulation of IL 2 production in systemic lupus erythematosus: an evolving paradigm
... In this issue of the JCI, evidence is presented that an anti-TCR/CD3 complex autoantibody present in SLE sera can bind to T cells and activate the Ca2+-calmodulin kinase IV CaMKIV signal[r] ...
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Diastolic spontaneous calcium release from the sarcoplasmic reticulum increases beat-to-beat variability of repolarization in canine ventricular myocytes after β-adrenergic stimulation.
... AP action potential APD action-potential duration βAR β-adrenergic receptor BVR beat-to-beat variability of repolarization duration CaMKII Ca2+/calmodulin-dependent protein kinase II CaT[r] ...
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Ca2+ regulatory proteins in cardiomyocytes from the right ventricle in children with congenital heart disease
... Abbreviations ANOVA: one-way analysis of variance; BLAST: Basic Local Alignment Search Tool; CaMKII: Ca2+/calmodulin-dependent protein kinase II; CASQ: Calsequestrin; CHD: Congenital Hea[r] ...
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Betaine promotes cell differentiation of human osteoblasts in primary culture
... Abbreviations ALP: alkaline phosphatase; BET: betaine; BGP: osteocalcin; BSP: bone sialoprotein; CaMKII: Ca2+/calmodulin-dependent protein kinase II; DiBAC4-3: bis-1,3-dibutylbarbituric [r] ...
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A Novel Mechanism for Calmodulin Dependent Inactivation of Transient Receptor Potential Vanilloid 6
... The paralogues TRPV5 and TRPV6 belong to the vanilloid subfamily of the Transient Receptor Potential (TRP) superfamily of ion channels and both play an important role in overall Ca 2+ homeostasis. The functioning of the ...
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Control of Ca2+ Influx and Calmodulin Activation by SK Channels in Dendritic Spines
... and calmodulin dynamics within an idealised, but biophysi- cally-plausible, dendritic spine, we show that SK-channels regulate calmodulin activation spe- cifically during neuron-firing patterns associated ...
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On the Ca2 + binding and conformational change in EF hand domains: Experimental evidence of Ca2 + saturated intermediates of N domain of calmodulin
... saturated structure of Clb. Similarly, we have used the apo form of the N-Cam domain structure from calmodulin (PDB code 1CFD), and built QLKI using Q41L and K75I mutations in N-Cam domain structure. Then the ...
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Retinoic acid inhibits calmodulin binding to human erythrocyte membranes and reduces membrane Ca2(+) adenosine triphosphatase activity
... unlabeled calmodulin. Another calmodulin-stimulable enzyme, bovine brain cyclic nucleotide phosphodiesterase, was unaffected by retinoic ...to calmodulin, studied spectrofluorometrically, was not ...
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Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca2+ release channel
... The results show that impaired CaM regulation of RyR2 is associated with an abnormal SR Ca2+ release and altered gene regulation, which lead to cardiac hypertrophy and early death of the[r] ...
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Calmodulin kinase II–mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice
... Blood Institute (NHLBI) grant (R01-HL089598), and a March of Dimes grant (MOD24172). M.G. Chelu is the recipient of the Michael Bilitch Fellowship in Cardiac Pacing and Electrophysi- ology, 2007–2008, from the Heart ...
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Tong Luo Jiu Nao ameliorates Aβ1–40 induced cognitive impairment on adaptive behavior learning by modulating ERK/CaMKII/CREB signaling in the hippocampus
... Furthermore, although the precise aetiology of AD is still less well known, beta-amyloid peptide (Aβ) has been widely accepted as a crucial pathogenic factor in disease development [12-14]. Several lines of evidence ...
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