Ca2+/calmodulin-dependent protein kinase
Ca2+/Calmodulin-dependent protein Kinase II interacts with group I Metabotropic Glutamate and facilitates Receptor Endocytosis and ERK1/2 signaling: role of β-Amyloid
... /calmodulin-dependent protein kinase IIα (CaMKIIα) can also regulate several ...mediated Ca2+ re- lease results in the dissociation of C-tail bound CaMKIIα and recruitment to the NMDA ...
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Regulation of Metabotropic Glutamate Receptor 5 activity by Ca2+/Calmodulin-dependent Protein Kinase IIα
... The excitatory neurotransmitter glutamate mediates many physiological processes in the central nervous system through ionotropic and metabotropic glutamate receptors (Ozawa et al., 1998; Nakanishi, 1992). The Group I ...
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The Role of Ca2+/Calmodulin Dependent Protein Kinase II Alpha in Group 1 Metabotropic Glutamate Receptor Endocytosis and Signalling
... Adult CD-1 mice were from Charles River (Wilmington, MA). Human Embryonic Kidney (HEK293) Cells were from American Type Culture Collection (Manassas, VA). Cell culture reagents were from Invitrogen (Burlington, ON): ...
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Herbal formula GAPT prevents beta amyloid deposition induced Ca2+/Calmodulin dependent protein kinase II and Ca2+/Calmodulin dependent protein phosphatase 2B imbalance in APPV717I mice
... Calcineurin (CaN), also known as protein phosphatase 2B (PP2B), is a calmodulin-dependent serine/threonine phosphatase physiologically activated by Ca 2+ . It is also highly expressed in the central ...
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Molecular basis for the modulation of native T type Ca2+ channels in vivo by Ca2+ /calmodulin dependent protein kinase II
... the kinase mediated the phosphorylation of Ser1198 in the II-III loop and the positive feedback regulation of channel gating both in intact cells in situ and in cells of the native adrenal zona glomerulosa ...
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Investigation of neuronal cell type-specific gene expression of Ca2+/calmodulin-dependent protein kinase II
... CaM kinase II indicates that the enzyme is carefully regulated at the level of ...CaM kinase II ...a protein bound to the DNA sequence of the gene ...
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A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1.
... Transfection of BJAB cells with the full-length CaM kinaseGr cDNA under control of the simian virus 40 promoter and enhancer in pSG5 resulted in the expression of two closely migrating p[r] ...
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Ca2+/calmodulin dependent protein kinase II regulates cardiac Na+ channels
... overexpression. CaMKII coimmunoprecipitates with and phosphorylates Na + channels. In vivo, transgenic CaMKIId C overexpression prolonged QRS duration and repolarization (QT intervals), decreased effective refractory ...
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Eph and NMDA receptors control Ca2+/calmodulin dependent protein kinase II activation during C elegans oocyte meiotic maturation
... MSP binding to VAB-1 and an unidentified receptor(s) antagonizes ephrin/VAB-1 and CEH-18-dependent inhibition (Fig. 5B) (Miller et al., 2003). Significant redundancy must exist in this mechanism, as MSP can still ...
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Linkage of β1 adrenergic stimulation to apoptotic heart cell death through protein kinase A–independent activation of Ca2+/calmodulin kinase II
... cAMP/protein kinase A (PKA) pathway to regulate vital cellular processes from the change of gene expression to the control of metabolism, muscle contraction, and cell .../calmodulin kinase II ...
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Advances of exosome in the development of ovarian cancer and its diagnostic and therapeutic prospect
... Exosome is an informative vesicle rich in proteins, nucleic acid, and lipids. The molecule composition of the exosome depends in part on the type and state of the originating cell. Exosome includes multiple categories of ...
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Development of a pooled probe method for locating small gene families in a physical map of soybean using stress related paralogues and a BAC minimum tile path
... horizontal and vertical probe pools. In order to further validate our data, a number of BAC clones that were pos- itive in MTP membrane hybridizations were reconfirmed by independent Southern hybridizations to BAC DNA ...
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The CaMKII/NMDAR complex as a molecular memory
... Recent experiments have sought to test directly the role of the CaMKII/NMDAR complex in memory. To address this issue, [22] utilized a knockin mouse with mutations L1298A and R1300Q in GluN2B that interfere with that ...
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p600 stabilizes microtubules to prevent the aggregation of CaMKIIα during photoconductive stimulation
... a proxy of neuronal death, via direct binding to calmodulin in a microtubule- independent manner. Using photoconductive stimulation coupled with live imaging of single neurons, we identified a distinct mechanism ...
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QUANTUM MECHANICAL NATURE OF PAIN SENSITIVITY
... Pain relief effect by injection with PS containing 45 Ca 2+ at 10 -4 M ouabain, which is accompanied with more pronounced dehydration effects on heart muscle as well as on brain cortex and cerebellum tissues (Fig. 4) ...
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Tight regulation of wingless type signaling in the articular cartilage subchondral bone biomechanical unit: transcriptomics in Frzb knockout mice
... Figure 4 Minor collagen expression after gain or loss of FRZB in ATDC5 cells. (A) Real-Time PCR analysis for collagen type 3 a 1 (Col3a1) and collagen type 5 a 1 (Col5a1) expression in the ATDC5 micro-masses ...
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Calcium/calmodulin-dependent kinase II and Alzheimer’s disease
... CaMKII is a holoenzyme of 12 subunits, each derived from one of four genes (α, β, γ and δ) [28]. In rat fore- brain, αCaMKII and βCaMKII are the most abundant subunits, with the former expressed 3–4 times more than the ...
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Release from the metaphase I block in invertebrate oocytes: possible involvement of Ca2+/calmodulin dependent kinase III
... Int J De\ IIi,,! 37 279 290 (1993) 279 Original Article Release from the metaphase I block in invertebrate oocytes possible involvement of Ca2+/calmodulin dependent kinase III HAYA ABDELMAJID,,4, CATH[.] ...
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Journal of Applied Pharmaceutical Science
... The voltage-dependent calcium channels have been the subjects of intensive research after chronic opioid exposure for the last few years (Little, 1995). A recent study has shown that calcium plays an important ...
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A protein phosphatase 2A deficit in the hippocampal CA1 area impairs memory extinction
... Calcium/calmodulin-dependent protein kinase II; cFC: contextual fear conditioning; CKO: Conditional knockout; Cont: Control; CS: Conditioned stimulus; DG: Dentate gyrus; DMSO: Dimethyl ...
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