Calcium Homeostasis
Effects of a synthetic peptide of a parathyroid hormone related protein on calcium homeostasis, renal tubular calcium reabsorption, and bone metabolism in vivo and in vitro in rodents
... indices of osteoclastic bone resorption. PTH-rP(1-34) and hPTH(1-34) also caused similar increases in bone resorption when incubated with fetal rat long bones in organ culture. Infusion of either peptide into ...
8
Rotavirus Disrupts Calcium Homeostasis by NSP4 Viroporin Activity
... ABSTRACT Many viruses alter intracellular calcium homeostasis. The rotavirus nonstructural protein 4 (NSP4), an endoplasmic reticulum (ER) transmembrane glycoprotein, increases intracellular levels of ...
12
Lifelong challenge of calcium homeostasis in male mice lacking TRPV5 leads to changes in bone and calcium metabolism
... The combination of reduced bone mass and increased endosteal resorption suggests that life-long stress on calcium homeostasis due to TRPV5 deficiency weakens the skeleton of old mice. Besides the effects on ...
14
Familial Alzheimer’s disease–associated presenilin 1 alters cerebellar activity and calcium homeostasis
... impaired calcium homeostasis and mitochondrial dysfunction in PS1-FAD PCs reduces their activity and contributes to motor coordination deficits prior to Aβ aggregation and ...2+ homeostasis and Aβ ...
17
A Study on Calcium Homeostasis Abnormalities in Patients taking Chronic Anticonvulsants Therapy in GGH, Chennai
... This is to certify that the dissertation entitled “A STUDY ON CALCIUM HOMEOSTASIS ABNORMALITIES IN PATIENTS TAKING CHRONIC ANTICONVULSANTS THERAPY IN GGH, CHENNAI” is a bonafide work done by ...
103
Calcium Homeostasis in Escherichia coli: Characterization of Mutants and Genome Expression of MG1655
... of calcium ions as secondary messengers has been well described in eukaryotic cells, little is known about calcium homeostasis in bacteria at the physiological and molecular ...address calcium ...
9
Functional Analysis of Picornavirus 2B Proteins: Effects on Calcium Homeostasis and Intracellular Protein Trafficking
... Intraorganelle calcium homeostasis. ER and Golgi complex Ca 2⫹ concentra- tions were determined using the calcium-sensitive photoprotein aequorin in a bioluminescence assay as described previously ...
9
TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells
... physiological calcium range in ER liposomes fused to planar ...intracellular calcium content in a PC2-dependent manner, impairs lyso- somal calcium re fi lling, causes cathepsins translocation, ...
17
Production of Infectious Human Cytomegalovirus Virions Is Inhibited by Drugs That Disrupt Calcium Homeostasis in the Endoplasmic Reticulum
... We previously reported that human cytomegalovirus (HCMV) infection induces endoplasmic reticulum (ER) stress, resulting in activation of the unfolded protein response (UPR). Although some normal consequences of UPR ...
10
Aspergillus fumigatus Calcipressin CbpA Is Involved in Hyphal Growth and Calcium Homeostasis
... increased calcium toler- ance of the ⌬ cbpA strain, we examined the transcriptional response to calcium stress, focusing on nine genes involved in cell wall biosynthesis, calcium homeostasis, ...
9
Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity.
... the calcium import activity of the ER ...of calcium homeostasis in the ER13, our results support that exogenously increased SERCA expression restored calcium homeostasis and relieved at ...
12
Williams-Beuren Syndrome Hypercalcemia: Is TRPC3 a Novel Mediator in Calcium Homeostasis?
... in calcium transport in ...in calcium homeostasis, we performed speci fi c immunostaining on the intestine and the kidney, major calcium-regulating ...that calcium metabolism ...
7
The acute neurotoxicity of mefloquine may be mediated through a disruption of calcium homeostasis and ER function in vitro
... added calcium results in a loss of neuronal viability (27%, Welch's test, P < ...a calcium response in neurons exposed to this buffer, presumably because the rinsing procedure did not remove all residual ...
14
Thioesterase mediated control of cellular calcium homeostasis enables hepatic ER stress
... of calcium homeostasis by palmitic acid requires the expression of Them2 and ...ER calcium (4, 5, 32), we next tested whether Them2 and PC-TP might facilitate the depletion of ER calcium in ...
17
Adenovirus E3-6.7K Maintains Calcium Homeostasis and Prevents Apoptosis and Arachidonic Acid Release
... Our results indicate that the E3-6.7K protein acted in the absence of other adenovirus proteins to protect transfected cells against TNF-, FasL-, and TRAIL-induced apoptosis and against [r] ...
10
Arginine vasopressin modulates electrical activity and calcium homeostasis in pulmonary vein cardiomyocytes
... 2+ homeostasis, and increased Ca 2+ spark frequency promotes arrhythmogenesis of PV cardiomyocytes in HF, which may play an important role in the development of AF ...2+ homeostasis, we suggest that ...
11
The Antifungal Activity of the Penicillium chrysogenum Protein PAF Disrupts Calcium Homeostasis in Neurospora crassa
... We showed previously that the toxicity of PAF is strongly influenced by the ionic strength of the test medium (21). Sim- ilarly, the activity of several other antifungal proteins (e.g., plant defensins) has been reported ...
9
Evidence for the Role of Calcineurin in Morphogenesis and Calcium Homeostasis during Mycelium-to-Yeast Dimorphism of Paracoccidioides brasiliensis
... In this study, we find that the plasma membrane Ca 2⫹ chan- nel Cch1p is a candidate for calcineurin regulation at the transcriptional level. The CCH1 mRNA transcript was lowered by chronic CsA in yeast cells of P. ...
9
Cardioprotection Via Modulation of Calcium Homeostasis by Thiopental in Hypoxia Reoxygenated Neonatal Rat Cardiomyocytes
... tosis virus (AMV) reverse transcriptase. A 20-µL reverse transcription reaction mixture containing 1 µg of total RNA, 1X reverse transcription buffer (10 mM Tris-HCl, pH 9.0, 50 mM KCl, 0.1% Triton X-100), 1 mM deoxy- ...
10
Excess NO stabilizes the luminal domain of STIM2 in a Cys-specific manner thereby regulating basal calcium homeostasis and store-operated calcium entry
... Hyperactivation of the STIM-mediated SOCE pathway results in dysregulated Ca 2+ homeostasis, underlying many pathological conditions including cardiovascular and neurodegenerative diseases (Luo et al., 2012; ...
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