cAMP response element (CRE)
A Family of cAMP-Response-Element-Related DNA Sequences With Meiotic Recombination Hotspot Activity in Schizosaccharomyces pombe
... the cAMP response element (CRE) consensus sequence for binding of cAMP-responsive transcription factors such as Atf1·Pcr1, suggesting a link between transcription and meiotic ...of ...
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Ghrelin through GHSR1a and OX1R heterodimers reveals a Gαs–cAMP cAMP response element binding protein signaling pathway in vitro
... stimulation, CRE activity was significantly higher than in ghrelin-treated single-transfected cells, suggesting that CRE activity is induced via the G α s/cAMP/cAMP-response ...
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Human SNF2L Gene Is Regulated Constitutively and Inducibly in Neural Cells via a cAMP Response Element
... cis-elements, cAMP response element (CRE)- and Sp1-binding ...intracellular cAMP levels, all neural cells were treated with forskolin and dbcAMP, two cAMP response ...of ...
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Adenosine A2Breceptors induce proliferation, invasion and activation of cAMP response element binding protein (CREB) in trophoblast cells
... intracellular cAMP [4,5,21]. cAMP is a secondary messenger involved in intracellular signal transduction, and also in the activation of protein ki- ...nases. cAMP-dependent protein kinase A (PKA) is ...
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The cAMP response element modulator (CREM) regulates T 2 mediated inflammation
... to CRE sites in the IL-4, IL-5 and IL-13 promoter regions and ATF3 binding sites were found enriched in a recent epigenomic analysis of regulated genes that play a role for T H 2 memory cell differentiation and ...
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Journal of Applied Pharmaceutical Science
... a CRE binding site as an enhancer. We choose the region with CRE binding site as it is one of the cAMP response element involved in transcriptional control of many of the human genes ...
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Targeted inactivation of the rickets receptor in muscle compromises Drosophila viability
... Fig. 2. Chronic in vitro stimulation results in rk desensitization. (A) Overnight stimulation with bursicon-conditioned media desensitizes rk receptors in vitro. HEK293 cells were transfected with rk, Pgl4.22 [a ...
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A functional cyclic AMP response element plays a crucial role in neuroendocrine cell type specific expression of the secretory granule protein chromogranin A
... potential cAMP response element (CRE) site at -68 bp virtually abolished promoter activity specifically in neuroendocrine (PC12 chromaffin or AtT20 corticotrope) cells, with little effect on ...
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Control of CREB expression in tumors: from molecular mechanisms and signal transduction pathways to therapeutic target
... zipper; cAMP, cyclic AMP; CBP, CREB-binding protein; ChiP, chromatin immunoprecipitation; CRE, cAMP response element; CREB, cAMP response element binding protein; ...
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Antidepressant like effects of acupuncture involved the ERK signaling pathway in rats
... (p)-ERK1/2, cAMP response element-binding protein (CREB), p-CREB and brain-derived neurotrophic factor (BDNF) in the hippocampus were examined using western ...
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Diet change and exercise enhance protein expression of CREB, CRTC 2 and lipolitic enzymes in adipocytes of obese mice
... The cAMP-response element-binding protein (CREB)- regulated transcription coactivator (CRTC) family com- prises three functionally diverse proteins: CRTC 1, 2 and ...
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Models of buffering of dosage imbalances in protein complexes
... the cAMP response element binding protein (CREB-binding protein or CBP) and the ac- tivator for thyroid hormone and retinoid receptors (ACTRs) ...
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Transcriptional regulation of the thyrotropin releasing hormone gene by leptin and melanocortin signaling
... adaptive response is caused by a reduction in thyrotropin-releasing hormone (TRH) expression that can be reversed by the administration of ...the cAMP response element binding pro- tein ...
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Original Article Dexmedetomidine alleviated isoflurane-induced neurotoxicity in aged rats
... Abstracts: Backgrounds: Age is a major risk factor for Alzheimer’s disease. Previous studies have shown that pa- tients with Alzheimer’s syndrome suffered greater risk when undergoing general anesthesia. As an inhalation ...
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Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington’s pathology in zQ175 mice
... Here, we show that pharmacological antagonism of mGluR5 abolishes the enhanced phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signal- ing observed in zQ 175 mice. Specifically, CTEP reverses ...
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Dietary potassium regulates vascular calcification and arterial stiffness
... Mechanistically, reduction in the potassium concentration to the lower limit of the physiological range increased intracellular calcium, which activated a cAMP response element–binding[r] ...
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Protein phosphatase 2A is a negative regulator of IL 2 production in patients with systemic lupus erythematosus
... phosphorylated cAMP response element–binding protein and its binding to the IL2 and c- fos promoters, as well as increased activator protein 1 activity, causing normalization of IL-2 ...
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Role of single nucleotide polymorphisms (SNPs) in common migraine
... CREB: cAMP response element binding; CREM: cAMP-responsive element modulator; CSD: Cortical spreading depression; CVD: Cardiovascular disease; DFFB: DNA fragmentation factor subunit ...
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Indication of nerve growth factor binding components from herbal extracts by HerboChip: a platform for drug screening on a chip
... cAMP response element binding protein phosphorylation PC 12 cells were starved for 5 h and then challenged with NGF and CM extract for 0, 2 or 5 ...anti-phospho-cAMP response ...
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Abnormalities of T cell signaling in systemic lupus erythematosus
... Abbreviations AP1, activated protein 1; APC, antigen presenting cell; CAMKIV, calcium/ calmodulin-dependent kinase IV; CD40L, CD40 ligand; CREB, cAMP response element-binding; CREM, cAMP[r] ...
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