cAMP responsive element binding
High expression of cAMP responsive element binding protein 1 (CREB1) is associated with metastasis, tumor stage and poor outcome in gastric cancer
... cAMP responsive element binding protein 1 (CREB1) has been reported to be implicated in tumor development and progression of human cancers. However, the clinical significance and regulatory ...
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Deficits in amygdaloid cAMP responsive element–binding protein signaling play a role in genetic predisposition to anxiety and alcoholism
... of cAMP-responsive element–binding protein (CREB) in genetic predisposition to anxiety and alcohol-drinking behaviors using alcohol-preferring (P) and -nonpreferring (NP) ...
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The cAMP responsive element binding protein 1 transactivates epithelial membrane protein 2, a potential tumor suppressor in the urinary bladder urothelial carcinoma
... CREB binding protein (CREBBP) is ...box binding protein-associated factor, 135 kDa (TAF4) to stimulate the deposition of the RNA polymerase II initiation complex and start transcription ...increasing ...
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Restoring synaptic plasticity and memory in mouse models of Alzheimer’s disease by PKR inhibition
... onset of AD [4]. In addition to Aβ accumulation, hyper- phosphorylation of tau is another well-known hallmark for AD [5]. Interestingly, both Aβ accumulation and tau hyper-phosphorylation are regulated by eukaryotic ...
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The Carbon monoxide releasing molecule ALF-186 mediates anti-inflammatory and neuroprotective effects via the soluble guanylate cyclase ß1 in rats’ retinal ganglion cells after ischemia and reperfusion injury
... AMC: Activated microglia; CO: Carbon monoxide; CORM: Carbon monoxide releasing molecule; CREB: cAMP responsive element binding protein; DMSO: Dimethylsulfoxid; FG: Fluorogold; GCL: Gangl[r] ...
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The Role of CREB in the Liver and Adipose Tissue
... The cAMP- responsive transcription factor cAMP-responsive element binding protein (CREB), thought to be a key activator of the hepatic gluconeogenic gene regulation program, has ...
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α-Viniferin Improves Facial Hyperpigmentation via Accelerating Feedback Termination of cAMP/PKA-Signaled Phosphorylation Circuit in Facultative Melanogenesis
... biopolymers. cAMP plays as a key second messenger in the generation of heavily pigmented melanosomes ...[6]. cAMP binds to the regulatory (R)-subunit within inactive PKA holoenzyme, concomitantly unleashing ...
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Role of single nucleotide polymorphisms (SNPs) in common migraine
... CREB: cAMP response element binding; CREM: cAMP-responsive element modulator; CSD: Cortical spreading depression; CVD: Cardiovascular disease; DFFB: DNA fragmentation factor ...
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Ghrelin through GHSR1a and OX1R heterodimers reveals a Gαs–cAMP cAMP response element binding protein signaling pathway in vitro
... of cAMP-response element luciferase reporter activity and cAMP ...s-cAMP-cAMP-responsive element signaling pathway in vitro and an increase in neuroblastoma cell ...
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cAMP responsive element mediated regulation of the gene transcription of the alpha 1B adrenergic receptor by thyrotropin
... To elucidate the molecular mechanism of the stimulatory effect of thyrotropin on the gene regulation of alpha 1B adrenergic receptor in functioning rat thyroid (FRTL-5) cells, we established a competitive ...
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Models of buffering of dosage imbalances in protein complexes
... protein in a diploid organism. In such cases there is an imbalance that increases the concentration of unpart- nered subunits. The deficit of one binding partner leaves the remaining partners in (relative) excess. ...
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Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts
... Glutaredoxin 5 (GLRX5) deficiency has previously been identified as a cause of anemia in a zebrafish model and of sideroblastic anemia in a human patient. Here we report that GLRX5 is essential for iron-sulfur cluster ...
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Human T-cell leukemia virus type 1 Tax transactivates the human proliferating cell nuclear antigen promoter.
... Although many growth factors, growth factor receptors, and transcription factors are transactivated by Tax, the precise mechanism of Tax transformation is not well understood. An intriguing target for viral oncoproteins ...
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Control of CREB expression in tumors: from molecular mechanisms and signal transduction pathways to therapeutic target
... Both in vitro and in vivo studies of tumors and corresponding non-malignant tissues as well as of tumor cell lines demonstrated high levels of CREB expression. The underlying molecular mechanisms of CREB overexpression ...
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C elegans EVI1 proto oncogene, EGL 43, is necessary for Notch mediated cell fate specification and regulates cell invasion
... We observed egl-43::YFP expression in the Z1.pp and Z4.aa cells in some transgenic lines, suggesting its weak expression in these cells. By contrast, YFP is consistently expressed in their daughter cells in all ...
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Abnormalities of T cell signaling in systemic lupus erythematosus
... Triggering of the TCR in SLE T cells leads to an abnormally accelerated and heightened tyrosine phos- phory lation of signaling intermediates, and increased calcium fl ux characterizing their hyper-responsive pheno ...
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Finding network modules and motifs regulating plant stress responses : integration and model ling across multiple data sets
... 1.2.5.5 Crosstalk between the signalling of different phytohormones The signalling events mediated by each individual phytohormone outlined above are not independent of each other, and the triggered pathways connect and ...
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Changes in the Spermatogenesis and Camp-Responsive Element Modulator (Crem) Gene Expression in Rat Treated With Salvia Hypoleuca
... hypoleuca caused a significant increase in sperm count and motility, and decrease in sperm abnormalities compared with control group and increased testis weight of[r] ...
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Cyclic adenosine monophosphate-responsive element-binding protein activation predicts an unfavorable prognosis in patients with hepatocellular carcinoma
... In addi- tion, we observed that the combined upregulation of CREB and pCREB was significantly associated with advanced tumor stage, high tumor grade, high serum AFP levels, and [r] ...
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Dietary potassium regulates vascular calcification and arterial stiffness
... Mechanistically, reduction in the potassium concentration to the lower limit of the physiological range increased intracellular calcium, which activated a cAMP response element–binding[r] ...
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