Canonical Wnt signaling
Hmga2is required for canonical WNT signaling during lung development
... conserved signaling pathways have been implicated in different phases of embryonic lung ...these signaling pathways and key transcription fac- tors of lung development, including NK2 homeobox 1 (also known ...
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Modulation of the canonical Wnt signaling pathway in bone and cartilage
... of canonical Wnt signaling at both the protein (β-catenin) and mRNA (Axin2) level between the axial and the appendicular ...increased Wnt/β-catenin ...of signaling molecules has also ...
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Original Article Oxidized phospholipids inhibit canonical Wnt signaling and osteoblast differentiation via ERK activation
... with Wnt-3a and/or ox-PAPC, and changes in canonical Wnt signaling pathway, ERK pathway, p38 MAPK pathway and the expression levels of bone-related genes were evaluated using real-time RT-PCR, ...
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Canonical WNT signaling components in vascular development and barrier formation
... encoding canonical WNT pathway members to evaluate the exact contribution of these components in CNS vascular development and in specification of the blood-brain barrier (BBB) and blood-retina barrier ...in ...
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Canonical Wnt signaling through Lef1 is required for hypothalamic neurogenesis
... Canonical Wnt signaling is required for the initial induction and subsequent AP pattering of the hypothalamus (Wilson and Houart, 2004). Our data indicate that Lef1 does not regulate either of these ...
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Structure–Function Dissection of the Frizzled Receptor in Drosophila melanogaster Suggests Different Mechanisms of Action in Planar Polarity and Canonical Wnt Signaling
... the canonical Wnt pathway and also via noncanonical pathways of which the best characterized is the planar polarity ...both canonical and planar polarity signaling requires interaction between ...
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Role of canonical Wnt signaling/β catenin via Dermo1 in cranial dermal cell development
... for Wnt/-catenin signaling in early cranial dermal development (Brault et ...the canonical Wnt signaling activity reporter and the Wnt responsive Axin2 mRNA are transiently ...
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Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis
... the canonical WNT inhibitor Dkk1 display a complete block in the formation of all five pairs of mammary placodes, based on the results of scanning electron microscopy and whole-mount in-situ hybridization ...
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R-spodin2 enhances canonical Wnt signaling to maintain the stemness of glioblastoma cells
... that Wnt/β-catenin path- way contributes to cancer development since the dis- covery that Wnt1 was capable of promoting breast cancer 30 years ago ...the Wnt/β-catenin signaling cascade such as APC, ...
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Canonical Wnt signaling is required for development of embryonic stem cell derived mesoderm
... is Wnt dependent during ES cell ...required Wnt signaling for their ...for Wnt signaling in antagonizing neural development (Aubert et ...
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Canonical Wnt signaling is required for the maintenance of dorsal retinal identity
... of Wnt signaling in a temporally- controlled manner, acting through distinct ...containing Wnt response elements (WREs) within their promoters, and Dkk1 specifically inhibits Wnts from ...
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Specification of osteoblast cell fate by canonical Wnt signaling requires Bmp2
... cWnt signaling, was modestly reduced in Bmp2 Prx1Δ/Δ cells and markedly diminished in Bmp2 Prx1Δ/Δ cells treated with Wnt3a ...essential signaling molecules of the cWnt pathway are expressed in Bmp2 Prx1Δ/Δ ...
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PubMedCentral-PMC5658260.pdf
... enhances canonical Wnt signaling across basal-like TP53-null models despite distinctions in both histopathology and gene expression ...Elevated Wnt/ β -catenin signaling occurs in the ...
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Wnt signaling in regulation of biological functions of the nurse cell harboring Trichinella spp
... non-canonical Wnt/PCP and Wnt/Ca 2+ signaling cascades are expressed in fully established NC A network of molecules participating in non-canonical Wnt signaling cascades, ...
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Wnt signaling: a promising target for osteoarthritis therapy
... the canonical Wnt signaling pathway in chondrogenic cells ...of Wnt signaling, led to enhanced expression of MMPs and accumulation of β-catenin in interleukin 1β (IL-1β)-stimulated ...
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WNT5A transforms intestinal CD8αα+ IELs into an unconventional phenotype with pro-inflammatory features
... by canonical WNTs, β-catenin translocates to the nucleus, where it associates with TCF/LEF family tran- scription factors to activate target gene ...While WNT/β-catenin has been ascribed a tumor stimulating ...
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Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation
... The canonical Wnt signaling pathway increases presynaptic inputs. (A) Representative images of Microtubule associ- ated protein 2 (MAP2; dark blue) and Vesicular glutamate transporter 1 (VGLUT1; ...
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Wnt signals mediate a fate decision between otic placode and epidermis
... Wnt3a signaling from the dorsal neural tube acts to specify dorsal otocyst fates, and that a balance of opposing Wnt and Shh signals is required for correct dorsoventral otocyst polarity (Riccomagno et ...
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A review on the diagnosis and treatment of hepatocellular carcinoma with a focus on the role of Wnts and the dickkopf family of Wnt inhibitors
... Wnts are cysteine-rich glycoproteins involved in multiple biological processes. Canonical Wnt signaling is summa- rized in Figure 1. Briefly, in the absence of Wnts, β -catenin, which serves as ...
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Klotho expression is a prerequisite for proper muscle stem cell function and regeneration of skeletal muscle
... the signaling pathways affecting regeneration of skeletal muscle is canonical Wnt signaling described to be increased in aged skeletal muscle ...of canonical Wnt ...
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