cardiac fibroblast
Oxymatrine inhibits aldosterone induced rat cardiac fibroblast proliferation and differentiation by attenuating smad 2, 3 and 4 expression: an in vitro study
... Fig. 2 Inhibitory effect of OMT on ALD-induced cardiac fibroblast proliferation. Cardiac fibroblasts were pretreated with 7.57 × 10 −4 mol/L [High] or 3.78 × 10 −4 mol/L [Low] OMT or without OMT for ...
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Cardiac fibroblast–derived microRNA passenger strand enriched exosomes mediate cardiomyocyte hypertrophy
... secretion. Cardiac fibroblasts produced and secreted exo- somes enriched with miRNA passenger strands (star miRNAs), which are usually degraded during miRNA biogenesis ...in fibroblast-derived exosomes ...
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The bHLH transcription factor Tcf21 is required for lineage specific EMT of cardiac fibroblast progenitors
... the cardiac fibroblast ...the cardiac fibroblast lineage prior to initiation of epicardial epithelial-to-mesenchymal transition ...form cardiac fibroblasts, and lineage tracing of the ...
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Cardiac fibroblast-specific p38α MAP kinase promotes cardiac hypertrophy via a putative paracrine interleukin-6 signaling mechanism
... from cardiac fibroblasts in re- sponse to b-adrenergic receptor stimulation or Ang II (19), and is able to directly induce cardiomyocyte hypertrophy (44, 45), and IL-6 KO mice are protected against LV hy- ...
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FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium
... with cardiac fibroblasts, which directly induce myocardial proliferation through a mechanism involving collagen/fibronectin and integrin signaling (Ieda et ...embryonic cardiac fibroblasts during ...
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Effects of interleukin-1 on cardiac fibroblast function: Relevance to post-myocardial infarction remodelling
... Following MI, the myocardium undergoes complex structural remodelling in an attempt to repair the damaged tissue and to overcome the loss of function induced by ischemia/reperfusion injury (Jugdutt, 2003). Post-MI ...
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Rosmarinic acid alleviates cardiomyocyte apoptosis via cardiac fibroblast in doxorubicin-induced cardiotoxicity
... Cardiomyocyte apoptosis is an important event in the process of DOX-induced cardiotoxicity and contributes to the initiation and progression of cardiac dysfunction [9, 31]. As shown in Figure 2A-B, DOX injection ...
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The transcription factor scleraxis is a critical regulator of cardiac fibroblast phenotype
... Cardiac P1 proto-myofibroblasts were plated onto glass coverslips infected at MOI 10 with AdLacZ or AdScx for 24 h. Cells were then fixed in 2 % paraformaldehyde (Alfa Aesar), permeabilized in 0.3 % Triton X-100 ...
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The role of MAP kinases in the regulation of mechanical load-induced procollagen gene expression in cardiac fibroblast
... of cardiac hypertrophy there is also an increase in the amount of ventricular collagen deposited (Thiedemann et al, 1983; Doering et al, 1988; Low et al, 1989) and this may lead to increases in collagen ...
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Interleukin 1 beta induces cardiac myocyte growth but inhibits cardiac fibroblast proliferation in culture
... Interleukin-1 (IL-1), initially called "endogenous pyrogen," is primarily known as a mediator of inflammation. However, it also plays many other diverse physiologic roles including the stimulation and inhibition ...
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Combined effects of interleukin-1α and transforming growth factor-β1 on modulation of human cardiac fibroblast function
... Co-stimulation of CF with IL-1α and TGFβ1 revealed that TGFβ1 had no inhibitory effect on the IL-1α-induced increase of IL-6 and IL-8. Surprisingly, the MMP3 induction observed with IL-1α treatment was further increased ...
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Sex Steroids and Stem Cell Function
... Gender may affect the healing of ische- mic myocardium through changes in the function of cardiac fibroblasts (CFs). These progenitor cells play a significant role in the remodeling of ischemic my- ocardium, and ...
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The Recombinant Human Secretory Leukocyte Protease Inhibitor (SLPI) protects cardiac fibroblasts injury against an in vitro ischemia/reperfusion injury
... of cardiac cell death is an over-secretion of protease enzymes surrounding the ischemic ...(sI/R)-induced cardiac fibroblast cell death. The adult rat cardiac fibroblasts (ARCFs) were isolated ...
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Original Article Role of miR-24 in myocardial fibrosis induced by angiotensin II
... In normal myocardial tissues, collagen fiber synthesis and metabolic imbalance can cause accumulation of collagen fibers and lead to myocardial fibrosis. Such lesions are closely associated with arrhythmia, ...
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Mesenchymal stem cells in cardiac regeneration: a detailed progress report of the last 6 years (2010–2015)
... improved cardiac function and higher efficiency of cell engraftment post MI in the case of ...of cardiac function ...high-density cardiac fibroblast was proposed for the development of ECM ...
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Fibroblast specific TGF β–Smad2/3 signaling underlies cardiac fibrosis
... reduced cardiac output resulting from a progressive loss of cardiomyocytes, ventricular chamber remodeling, and accumu- lation of interstitial fibrosis ...tissue-resident cardiac fibroblast, which ...
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Periodontal-induced chronic inflammation triggers macrophage secretion of Ccl12 to inhibit fibroblast-mediated cardiac wound healing
... Periodontal disease (PD) is associated with adverse wound healing in response to injury across organ sys- tems, including poor cardiac responses to myocardial infarction (MI) (1–6). MI incidence correlates with ...
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Fibroblast biology Effector signals released by the synovial fibroblast in arthritis
... Synovial fibroblasts release growth factors (granulocyte- macrophage colony stimulating factor and colony stimulat- ing factor-1) that regulate the development and activation of hematopoietic cells and their precursors ...
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Saikosaponin A Protects From Pressure Overload-Induced Cardiac Fibrosis via Inhibiting Fibroblast Activation or Endothelial Cell EndMT
... on cardiac remodeling and fibrosis, however, remains ...mouse cardiac remodeling and fibrosis ...on cardiac hypertrophy but decreased cardiac fibrosis ...mouse cardiac fibroblasts were ...
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Towards the development of a reliable protocol for mesenchymal stem cell cardiomyogenesis
... The specific transformative steps that occur from the multipotent through the mature car- diomyocyte state are determined in large part by changes in gene expression. The exact differen- tiation and developmental ...
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