Cardiac stem cells
Developmental origin and lineage plasticity of endogenous cardiac stem cells
... clinical cardiac regeneration by injection of precursor cells or other approaches has not yet been ...of cardiac stem cells might be to induce the re-awakening of cell proliferation, ...
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Endogenous cardiac stem cells for the treatment of heart failure
... endogenous cardiac progenitors have been used in the recently completed CADUCEUS and “Administration of cardiac stem cells in patients with ischemic cardiomyopathy” (SCIPIO) clinical trials ...
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Original Article SDF-1α promotes repair of myocardial ischemic necrosis zones in rats
... chymal stem cells (UC-MSCs), which could effectively protect left ventricular function of myocardial infarction and relieve cardiac func- tions of AMI ...mesenchymal stem cells, ...
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Nanomaterials modulate stem cell differentiation: biological interaction and underlying mechanisms
... on stem cell differentiation ...the stem cell differentiation ...of stem cell differentiation and can serve as a potential tool to promote the differentiation of hESCs into cardiomyocytes ...of ...
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New Technologies for Treatment of Coronary Artery Disease
... harvested cells contain a multitude of cells with a small proportion of stem cells ...mesenchymal stem cells are found in even lower concentrations than that of mononuclear ...
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Intramyocardial transplantation of cardiac mesenchymal stem cells reduces myocarditis in a model of chronic Chagas disease cardiomyopathy
... expressed cardiac-lineage specifiers, such as GATA-4, and connexin 43, but failed to differentiate completely into beating cardiomyocytes in vitro ...of cardiac stem cells ...
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Drug and cell delivery for cardiac regeneration
... in stem cell niches similar to those of highly regenerating tissues in the post-natal senescent heart, and can undergo symmetric or asymmetric division, giving rise to more CSCs or commit- ted ...resident ...
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Therapeutic use of stem cells for cardiovascular disease
... improve cardiac function after myocardial ...of cells have been explored, each with their own benefits and ...pluripotent stem cells possess an embryonic-like state and therefore have a high ...
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Challenges in identifying the best source of stem cells for cardiac regeneration therapy
... clinical cardiac regeneration experience suggests that stem cell therapy can be safely performed, but it also underlines the need for reproducible results for their effective use in a real-world ...suited ...
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Bone-derived Nestin-positive mesenchymal stem cells improve cardiac function via recruiting cardiac endothelial cells after myocardial infarction
... apoptotic cells in myocardium repair post-MI ...salvaging cardiac function, in addition to the en- hanced chemotactic ...+ cells were observed around the CM-Dil-labeled transplanted cells in ...
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Differentiation of human adipose-derived stem cells into cardiomyocyte-like cells in fibrin scaffold by a histone deacetylase inhibitor
... adult stem cells into cardiac cells need to be refined, since none of them couldn’t lead to the creation of functional cardiac cells ...for cardiac differentiation ...of ...
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11 guided reading activity
... Complete the following table, which compares embryonic stem cells to adult stem cells.. Embryonic stem cells Adult stem cells.[r] ...
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Modelling cardiac fibrosis using three-dimensional cardiac microtissues derived from human embryonic stem cells
... CM-MSC cardiac microtissues To further explore the applicability of CM-MSC cardiac microtissues to drug-induced cardiac fibrosis models, we examined reference pro-fibrotic mediators, including ...
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Dose-dependent improvement of cardiac function in a swine model of acute myocardial infarction after intracoronary administration of allogeneic heart-derived cells
... Doses greater than 25 × 10 6 CDC have been reported to be deleterious in prior large animal studies [5], in- creasing cTnI in a dose-dependent manner. In the present study, we report the beneficial effects of both 25 × ...
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Human embryonic stem cell-derived cardiomyocyte therapy in mouse permanent ischemia and ischemia-reperfusion models
... Ischemic heart disease is a leading cause of death world- wide [1]. Cardiac ischemia, known as myocardial infarc- tion (MI), usually triggers massive cardiomyocyte death. Due to the limited regenerative capacity ...
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Mesenchymal stem cells for cardiac repair: are the actors ready for the clinical scenario?
... implanted cells, the benefits were modest and clinical translation is currently ...acellular cardiac scaffolds that display preserved cardiac extracellular matrix ...ing cardiac function post ...
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Developing insights into cardiac regeneration
... The architecture of the chromatin is an important aspect of gene regulation and thus of the gene regulatory networks. Vincent Christoffels (Academic Medical Center, Amsterdam) used 4C- seq, a technique that probes ...
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Heart on a chip: Micro-nanofabrication and microfluidics steering the future of cardiac tissue engineering
... the cardiac marker proteins ...uniform cardiac tissue with homogeneous beating (figure 2) ...upregulated cardiac biomarkers and enhanced cardiac ...of cells and increased thickness ...
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Stem cells of the reproductive tract of women
... into cells of the granulosa phe- notype in addition to epithelial, neural, and mesenchymal cell types, and when stimulated with estrogen, it differ- entiates directly into ...(BM) cells seed the ovaries ...
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Gene Expression Analysis Of Cardiomyocytes Differentiated From Human Bone Marrow Derived Mesenchymal Stem Cells
... mesenchymal stem cells from adult bone marrow can be differentiated in to cardiac like muscle cellsby treating the cells with various agents like 5-azacytidine, laminin, oxytocin, DMSO ...
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