Cardiomyocyte proliferation
IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development
... the proliferation of primary fetal cardiomyocytes (Liu et ...induces cardiomyocyte proliferation (Fraidenraich et ...influences cardiomyocyte proliferation and ventricular compact zone ...
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Induction of cardiomyocyte proliferation and angiogenesis protects neonatal mice from pressure overload–associated maladaptation
... by recruiting monocytes into the myocardium, which in turn promote angiogenesis (37, 44, 45). Pressure overload at the adult stage in mice is also associated with increased abundance of inflammatory cells (mainly ...
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Regulatory T-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner
... impaired cardiomyocyte survival [4, ...that proliferation of pre-existing cardiomyocytes is the major mechanism by which the neonatal heart regenerates [6, ...regulates cardiomyocyte ...
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In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration
... through cardiomyocyte proliferation (Qu et ...on cardiomyocyte proliferation, we exposed 3 dpf embryos to a panel of compounds reported to target common developmental signaling pathways (Sun ...
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Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development
... and cardiomyocyte proliferation is enhanced at least partly through reduction of intracellular cAMP ...reduced cardiomyocyte proliferation seen in the zebrafish Npr3 knockdown embryos is ...
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Cardiomyocyte proliferation prevents failure in pressure overload but not volume overload
... Cardiomyocyte proliferation signaling pathways in D2-TAC mice. Unbiased analysis of RNA-sequencing (RNA-seq) data sets using the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was employed to ...
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Adipose stromal cells primed with hypoxia and inflammation enhance cardiomyocyte proliferation rate in vitro through STAT3 and Erk1/2
... on cardiomyocyte proliferation, ADSC were treated with 10 μg/ml mitomycin-C (Sigma-Aldrich, Boston, MA) for 3h, followed by extensive washing with PBS prior the co-culture with rnCM and HL-1 ...
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Building and re building the heart by cardiomyocyte proliferation
... reduced cardiomyocyte proliferation after ventricular injury and disrupts ...reduces cardiomyocyte proliferation and prevents compensatory growth after apical resection and ...of ...
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Knockout of SRC-1 and SRC-3 in Mice Decreases Cardiomyocyte Proliferation and Causes a Noncompaction Cardiomyopathy Phenotype
... of cardiomyocyte proliferation and differentiation dur- ing cardiac development, we proposed that SRC-1 and SRC-3 could play important roles in myocardial proliferation and ...reduced ...
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In vivo analysis of cardiomyocyte proliferation during trabeculation
... in cardiomyocyte proliferation at later stages, we repeated the ErbB2 inhibition experiment at all three aforementioned stages on Tg(myl7:H2B-GFP); Tg(myl7:MKATE- CAAX) larvae, and quantified the number of ...
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Multicolor mapping of the cardiomyocyte proliferation dynamics that construct the atrium
... by cardiomyocyte proliferation, which we have characterized by tracking clonal populations of atrial cardiomyocytes at successive stages of ...heterogeneous proliferation of muscle clones contributes ...
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VEGF attenuates development from cardiac hypertrophy to heart failure after aortic stenosis through mitochondrial mediated apoptosis and cardiomyocyte proliferation
... In current, myocardial regeneration has become the hotspot and challenge of clinical treatment for heart fail- ure. It may offer possibilities that could supplement apoptosis-conduced CMs shortage and maintain the ...
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The regenerative capacity of the zebrafish heart is dependent on TGFβ signaling
... (A,A ⬘ ,C,C ⬘ ) Heart sections of transgenic cmlc2::DsRed2-Nuc (red) fish immunostained for Tropomyosin (blue) and Mcm5 (green) to detect mitotic cells at 14 dpci. DAPI (yellow in the left panels) marks nuclei. ...
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miR-486 is modulated by stretch and increases ventricular growth
... connecting the RV to the pulmonary artery (PA), as compared with control RV tissue. For several years, albeit not current practice, the surgeon would remove a small piece of the RV in order to connect the RV/PA shunt to ...
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Development of a human cardiac organoid injury model reveals innate regenerative potential
... pH3 cardiomyocyte proliferation quantification, multiple images were taken at random locations throughout the tissue and cardiomyocyte proliferation quantification was performed ...
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How to make a cardiomyocyte
... of cardiomyocyte proliferation, with the aim of manipulating these pathways to reactivate cardiomyocyte proliferation in the injured adult mammalian ...as proliferation inducers of ...
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Epigenetics and Mechanobiology in Heart Development and Congenital Heart Disease
... can regulate gene expression via miRNAs. The chromatin remodeling protein BAZ2A was also found to be regulated by these three miRNAs (Table 1), but its role in HLHS, hypertrophy, and heart failure remains to be ...
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The small molecule Chicago Sky Blue promotes heart repair following myocardial infarction in mice
... CSB inhibits cardiac neutrophil and macrophage activation. In addition to improved cardiac function, CSB reduced scar size in adult mice following MI. These observations led us to examine whether CSB affects the immune ...
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Original Article MicroRNA-152-3p negatively regulates ischemia-reperfusion induced cardiomyocyte apoptosis by inhibiting PTEN
... induced cardiomyocyte apoptosis by target- ing HSP-20 ...promote cardiomyocyte apoptosis and myocardial I/R injury, and its downregula- tion reduces cardiomyocyte apoptosis and death in mice ...cell ...
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Original Article Inhibition of microRNA-182 reduces hypoxia/re-oxygenation-induced HL-1 cardiomyocyte apoptosis by targeting the nuclear respiratory factor-1/mitochondrial transcription factor A (NRF-1/mtTFA) pathway
... cessfully maintained and passaged [8]. Mo- lecular studies using in vitro and in vivo models and clinical studies have revealed that multiple genetic factors are associated with ischemic heart disease in individuals and ...
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