Cardiovascular research

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Changes in the Geographic Pattern of Iran's International Collaboration in Cardiovascular Research: A 15-Year Period

Changes in the Geographic Pattern of Iran's International Collaboration in Cardiovascular Research: A 15-Year Period

Background: Cardiovascular Diseases (CVDs) which are considered as the major public health problems, result in substantial increases in economic and health care costs, and are the first leading cause of death worldwide. Clinical research are the backbone of attempts to build and conduct evidence-based policies to perform the best caring of CVDs. International collaborations, increase the quality of research. Therefore, the present study was conducted in order to assess the changes in the geographic pattern of Iran's international cardiovascular research collaborations. Methods: This study was a systematic review with scientometrics approaches. Numbers and rates of international research collaborations were extracted from the "Web of Science" database. Results are reported as figures by Graph Pad v6 and Arc GIS v7 software.
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The joint cardiovascular research profile of the university medical centres in the Netherlands

The joint cardiovascular research profile of the university medical centres in the Netherlands

Abstract Biomedical scientific research in the Nether- lands has a good reputation worldwide. Quantitatively, the university medical centres (UMCs) deliver about 40 % of the total number of scientific publications of this research. Analysis of the bibliometric output data of the UMCs shows that their research is highly cited. These output-based anal- yses also indicate the high impact of cardiovascular scien- tific research in these centres, illustrating the strength of this research in the Netherlands. A set of six joint national cardiovascular research topics selected by the UMCs can be recognised. At the top are heart failure, rhythm disor- der research and atherosclerosis. National collaboration of top scientists in consortia in these three areas is successful in acquiring funding of large-scale programs. Our obser- vations suggest that funding national consortia of experts focused on a few selected research topics may increase the international competitiveness of cardiovascular research in the Netherlands.
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Long non-coding RNA Databases in Cardiovascular Research

Long non-coding RNA Databases in Cardiovascular Research

The growing number of interconnected lncRNA databases reflects the immense research interest in lncRNAs, which is increasingly gaining momentum in the quest to understanding the (dys)function of biomolecular networks potentially contributing to complex human diseases [74]. Current high-throughput technologies joined with massive parallel sequencing generate data for non-coding transcripts at an unprecedented scale. To date, there is still a strong disconnec- tion between the large number of identified transcripts and the small amount of lncRNA functional data, which is illustrated best by two of the most cited lncRNA databases, NONCODE and lncRNAdb. While NONCODE contains as much as 167,150 known human lncRNA transcripts, lncRNAdb is ded- icated to functionally-characterized lncRNAs, restricting its content to 183 human lncRNAs. However, even for well- characterized lncRNAs, such as ANRIL, further investigation is warranted. Despite the wealth of information from public databases, the exact mechanisms of ANRIL functionality remain enigmatic. Another drawback are occasional discrep- ancies across databases for similar queries, which force researchers to use and compare several databases [25]. When choosing a database, researchers should also assure that the database of interest is curated and regularly updated as novel information becomes available. For instance, the Functional lncRNA Database [75] was not considered for this review since it has last been updated in March 2012. Nevertheless, current databases offer valuable resources for integration and interpre- tation of various kinds of experimental lncRNA data. This is essential for understanding the function and relevance of these versatile molecules and may pave the way to new translational applications in cardiovascular research.
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The effect of resistance exercise on mean blood pressure in the patients referring to cardiovascular research centre

The effect of resistance exercise on mean blood pressure in the patients referring to cardiovascular research centre

the cardiovascular research center. The type of the exercises and movements, performed in the sessions, was selected based on articles and indications of the experts in this context. Firstly, the questionnaire of demographic characteristics, consumed medications, and history of physical exercise was filled . Subjects’ BP was measured from both their hands held at the heart level, 1 day prior to exercise, after making them sit on a chair calmly, with their feet on the ground. They should not have had coffee or tea in the past 30 min, and avoided speaking due to a possible false BP increase. Then, their mean BP levels were recorded. a calibrated Richter sphygmomanometer with appropriate size of cough, its reliability had been established based on test–re‑test, with 40% width of arm circumference and length of 80% of arm circumference, being fastened 2.5 cm above the brachial artery. [13] This procedure was repeated 1 day after the last
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Danish Cardiovascular Research Academy and Faculty of Health Sciences University of Copenhagen

Danish Cardiovascular Research Academy and Faculty of Health Sciences University of Copenhagen

Participants: 30-40 PhD students connected to The Danish Cardiovascular Research Academy (DaCRA) and who are interested in cardiac arrhythmia. External applicants are also invited to apply for participation. Both PhD students with a primary interest in basic science and those with a primary interest in clinical aspects of arrhythmia are encouraged to participate.

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Questioning patient engagement: research scientists’ perceptions of the challenges of patient engagement in a cardiovascular research network

Questioning patient engagement: research scientists’ perceptions of the challenges of patient engagement in a cardiovascular research network

This study aimed to assess researchers’ perceptions of the meaning and value of patient engagement in research within the context of a Canadian cardiovascular research network. Our targeted recruitment of network member participants assisted our team to achieve our aim, and the knowledge gleaned from this work will inform further development of our patient engagement strategy. Although the survey response rate was low, limiting generalizability to similar networks, our multi-method approach to data collection allowed for greater reach across the network. While the ratio of cardiologists included in our interviews echoes the make-up of C-SPIN as a research network, and is therefore representatives of perspectives within this group, it may not be representative of researchers at large.
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Understanding factors associated with the translation of cardiovascular research: a multinational case study approach

Understanding factors associated with the translation of cardiovascular research: a multinational case study approach

From the perspective of studies that start with the aim of assessing the impact of research, progress has been made on identifying examples and assessing the level of impacts from health research, but usually in the context of a single country [10-16]. Some of these examples have systematically explored the comparative impact on healthcare of different types of research (basic and clin- ical) and different modes of funding (projects, fellow- ships etc). Other studies have started with a series of health policies and systematically identified factors linked to research use in these cases [17]. However, as far as the authors are aware, no previous study started by estimating the impacts from a diverse series of pro- jects and then worked back from that to identify com- mon factors among those projects which have high or low impact. That is what we attempted in the study de- scribed here. To analyze systematically the full range of factors that might be associated with the scientific success of research, and its translation, requires a series of steps. We aimed to conduct a suite of case studies to provide a robust assessment of the level of
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Engaging older patients in cardiovascular research: observational analysis of the ICON-1 study

Engaging older patients in cardiovascular research: observational analysis of the ICON-1 study

Patients approached to participate in ICON-1 were generally enthusiastic about participating in clinical research, citing their altruistic wish to ‘ give something back ’ and improve the treatment of patients presenting in future. This contradicts previous evidence; one car- diovascular RCT in patients aged 70 – 82 years found that the primary reason for taking part in research was self- interest (52.9%), access to ‘ health checks ’ or ‘ peace of mind ’ , followed by a sense of altruism (39.6%) to ‘ help research ’ or ‘ help others ’ . 15 Indeed, several patients recruited to ICON-1 mentioned the importance of as few clinic visits as possible after initial recruitment, citing a lack of transport. Seven patients cited distance from the research venue as a reason for declining to par- ticipate; previous research demonstrated inverse correl- ation between the distance from the older patient ’ s residence to the research venue, and the likelihood of participation in a clinical trial. 16
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PhD School of Molecular Metabolism and Danish Cardiovascular Research Academy

PhD School of Molecular Metabolism and Danish Cardiovascular Research Academy

of Endocrinology Odense University Hospital DENMARK Henning.beck-nielsen@ouh.regionsyddanmark.dk Sten Christensen (SC) Course leader Professor Dept. of Pharmacology University [r]

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Biomaterials in cardiovascular research: applications and clinical implications

Biomaterials in cardiovascular research: applications and clinical implications

significant immobilization of EPC and a similar preparation using SDF-1/heparin found to recruit both EPCs and smooth muscle progenitor cells tackling the two important issues, namely, endothelization and remodeling of blood vessels [88, 89]. EPC capture technology is the way through which circulating EPC is captured by using anti-CD34 + that was impregnated on the surface of stents. Genous R-Stent is the first medical device utilizing this technology [90] and various clinical investigations evaluated this device compre- hensively. One of the studies postulated that this EPC capture technology was feasible and safe for primary percutaneous coronary intervention for STEMI without the incidence of late stent restenosis [91]. In another independent trial, coronary stenting with the Genous resulted in good clinical outcomes and low incidences of repeat revascularization and stent thrombosis [92]. However, some recent evaluation came in contrast to the above findings, where they reported higher risk of restenosis while using Genous compared to drug- eluting stents [93]. To add further, Genous stent used in a population of elderly patients resulted in a significantly higher target vessel failure rates compared with younger patients. Moreover, target lesion revascularization rates were higher with increasing age and there was no difference in stent thrombosis [94]. Another worthy research to mention is the use of exponential enrichment technology in which DNA-aptamers with a high affinity to EPCs were identified. These EPC specific molecules are grafted on the surface of polymer disk [95], stents [96], and Ti-implants [97] found to attach EPCs to the aptamer-coated implants. This selective adhesion of EPCs promoted endothelial wound healing and also decreased the neointimal hyperplasia to a certain extent. Recent researches utilize various cell sources for treat- ment of cardiovascular diseases. Human embryonic stem cells (h-ESC), mesenchymal stem cells, endothelial
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A Corpus of Potentially Contradictory Research Claims from Cardiovascular Research Abstracts

A Corpus of Potentially Contradictory Research Claims from Cardiovascular Research Abstracts

Aspirin has been widely used as a pain killer and an effective drug for preventing blood clots. A conflict on its benefits started when doctors began prescrib- ing a daily dosage to protect heart attack victims from further attacks. At that time there was no biomedical research to prove that this was effective. An attempt to investigate [9] found that aspirin was significantly beneficial in preventing heart attacks. However, a sub- sequent trial was less confident about that because it found little difference between the fatality rate of people who never used, seldom used or often used aspirin [10]. Another study [11] was compatible with that result as it failed to show the preventative role of aspirin on heart attacks. The first team, who found a significant benefit of aspirin on the heart, conducted another experiment [12] and reported a positive results that supported their first claim. The contradictions between aspirin research claims lasted 20 years, until researchers finally concluded that aspirin reduces the risk of non-fatal heart attacks, but its effects on other problems such as stroke are still unclear [13].
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Patient involvement in cardiovascular research: a qualitative impact evaluation

Patient involvement in cardiovascular research: a qualitative impact evaluation

This case study aimed to evaluate whether the written advice of a patient’s committee helped cardiovascular researchers to improve their proposal before submitting it for funding. Overall, we found that more than one third of the points of advice given by the patient committee were incorporated into the final proposals: researchers added details on the relevance and the risks of the study for patients, used simpler language and added information about the role of patients throughout the research. Pro- cedural and contextual changes in the current process of the patient committee could enable researchers to adapt more fundamental suggestions as well. We believe that the lessons learnt are relevant for others organising patient involvement in research, particularly in projects in which patients have an advisory role. Further effort is required to increase the value that is currently attributed to patient involvement, and to support researchers in the required organizational and cultural changes to meaningfully in- volve patients in research.
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Cardiovascular science: opportunities for translating research into improved care

Cardiovascular science: opportunities for translating research into improved care

Cardiovascular research is progressing on many fronts, as highlighted in the collection of Reviews in this issue of the JCI. MicroRNAs that regulate cardiac function have been implicated in cardiac disorders, and efforts to develop therapeutic antagomirs are underway. The genetic bases of several cardiac disorders, including cardiomyopathies that cause heart failure and channelopathies that underlie cardiac arrhythmias, have been elucidated. Genetic test- ing can identify asymptomatic individuals at risk, potentially leading to effective preventative measures. Growing evidence supports the role of chronic inflammation in atherosclerosis, providing new opportunities for therapeutic intervention. For heart failure, recent work suggests that cardiac regeneration using stem/progenitor cells, gene transfer, new drugs that restore normal Ca 2+ cycling, and agents that reduce reperfusion injury following myocardial
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Public and Patient Involvement in Research for the Leicester Cardiovascular Biomedical Research Unit

Public and Patient Involvement in Research for the Leicester Cardiovascular Biomedical Research Unit

2) Establish ourselves as the regional hub for translational cardiovascular research – measured deliverables will include evidence of increased collaborations with other local and regional NIHR structures and with other University/NHS partners (Loughborough and Nottingham). There is a strong drive from the PPI Group to continue to make best use of research through collaboration with healthcare and academic partners. The involvement of patients and the public is vital in ensuring our research has maximum impact in translation to healthcare by meeting patient and public need and will be a fundamental and integrated part of the development of the BRU into a regional hub for cardiovascular research.
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Real-world effectiveness of valsartan on hypertension and total cardiovascular risk: review and implications of a translational research program

Real-world effectiveness of valsartan on hypertension and total cardiovascular risk: review and implications of a translational research program

Abstract: The pharmacological efficacy of various monotherapy, single pill, and combination therapies of the angiotensin II receptor blocker valsartan have been established, mainly through randomized controlled trials that used similar methodological and statistical platforms and thus enabled synthesis of evidence. The real world effectiveness of valsartan has been studied extensively, but the relative lack of scientific and technical congruence of these studies render synthesis virtually impossible. To date, all have focused on blood pressure outcomes, despite evidence-based calls to grade antihypertensive treatment to patients’ total cardiovascular risk. We review a T3 translational research program of seven studies involving valsartan monotherapy as well as single and separate pill combinations, and the determinants and effect on blood pres- sure and total cardiovascular risk outcomes. All seven studies examined not only the impact of valsartan-based regimens on blood pressure values and control, but also, within a statistical hierarchical approach, the physician- and patient-related determinants of these blood pressure outcomes. Two studies also investigated the determinants and outcomes of valsartan-based treatment on total cardiovascular risk – among the first studies to use this risk coefficient as an outcome rather than only a determinant. These seven studies included a total of 19,533 patients, contributed by 3434 physician-investigators in Belgium – a country particularly well-suited for observational effectiveness studies because of demographics and epidemiology. Each study used the same methodological and statistical platform. We summarize the impact of various valsartan regimens on such outcomes as blood pressure values and control, change in total cardiovascular risk, and reduction in risk by at least one category. We also review the results of statistical multilevel and logistic modeling of physician- and patient-related determinants on these outcomes, including the proportion of variance attributable to a physician class effect before patients enter the equation. In its different formulations, valsartan has major real-world benefits in lowering blood pressure and total cardiovascular risk within a 90-day period. It is essential to understand the physician- and patient-related determinants of blood pressure and total cardiovascular risk outcomes associated with valsartan treatment. Antihypertensive research should expand its historical focus on lowering blood pressure with an emphasis on lowering total cardiovascular research.
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Sex and cardiovascular disease status differences in attitudes and willingness to participate in clinical research studies/clinical trials

Sex and cardiovascular disease status differences in attitudes and willingness to participate in clinical research studies/clinical trials

Our study of attitudes towards CRS/CTs among Iowans with chronic conditions shows no significant differences in WTP for women or people with CVD (and/or major risk factors). With respect to attitudes towards various aspects of clinical research, the few observed differences suggest that women have more favorable attitudes. Simi- larly, patients with CVD have attitudes towards various elements of CRS/CTs similar to those of patients with other chronic conditions. These results contradict the findings from prior research on patient attitudes on WTP in CVD clinical trials. They also are inconsistent with the experience of enrollment by women in studies on CVD prevention and treatment. Better understanding of why women with CVD – who are as favorably disposed to participation as are men – do not enroll in comparable numbers is an important topic for future research to ensure more equitable representation of women in clinical research on CVD.
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Cardiovascular instrumentation

Cardiovascular instrumentation

model case of a vessel containing blood flowing with a single velocity, the output from the Doppler flowmeter will be a single frequency component, with frequency and amplitude dependent[r]

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Cardiovascular Sonography

Cardiovascular Sonography

the college is committed to providing health care educational opportunities in formats that meet the needs of prospective students in the community. these formats include both the standard, face-to-face classroom approach and innovative distance electronics. By combining the most contemporary teaching modalities with state-of-the-art technology, our students are assured of obtaining the most comprehensive education possible. the College of health Care Sciences believes in excellence and innovation in teaching, research, service, and learning. this is made possible by having an academically skilled and professionally qualified faculty and staff. We have diverse faculty members. they come from different backgrounds, have different degrees, and possess a wide range of educational experiences. our faculty members are eager to share their knowledge of and expertise in the health care arena with their students. We also have an open door policy that encourages students to seek answers to their questions, allowing them to develop a solid understanding of the materials that they study.
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Trans people and cardiovascular disease. What is Cardiovascular Disease?

Trans people and cardiovascular disease. What is Cardiovascular Disease?

There are various options for treating cardiovascular disease. Ask for information about your options and take the time to consider which one you feel best about trying. Your nurse/doctor may encourage you to stop smoking or reduce the amount you smoke, get more exercise, make changes in your diet, learn relaxation techniques, take medication (e.g., to lower your blood pressure), or change the type of hormones you are taking. The Transgender Health Program’s training for nurses and

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Research Article Cardiovascular Risk in Psoriasis: A Population-Based Analysis with Assessment of the Framingham Risk Score

Research Article Cardiovascular Risk in Psoriasis: A Population-Based Analysis with Assessment of the Framingham Risk Score

The 10-year FRS for general CVD, which includes car- diovascular events of myocardial infarction, cardiovascular death, angina, stroke, intermittent claudication, and heart failure, was calculated [10]. For those without lipid values, we instead applied the office-based 10-year FRS which does not require laboratory values for calculation of the FRS. Since information on stroke and intermittent claudication was not collected in our study, the FRS was recalibrated to the subset of cardiovascular events collected in our population using calibration coefficients provided with the published algorithm [10].
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