cartilage degradation
Tibolone inhibits bone resorption without secondary positive effects on cartilage degradation
... of cartilage degradation measured in the systemic fluids, serum and urine, are the net results of the biological activity of all joints and tissues in which col- lagen type II ...articular cartilage, ...
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Biochemical markers identify influences on bone and cartilage degradation in osteoarthritis the effect of sex, Kellgren Lawrence (KL) score, Body Mass Index (BMI), oral salmon calcitonin (sCT) treatment and diurnal variation
... while cartilage deg- radation is correlated with increasing KL-score and only weakly correlated with ...and cartilage degradation is not ...prevent degradation of both tissues to varying ...
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Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity
... ular cartilage is reversible and that proteoglycan levels are restored after limited times of joint immobilization ...of cartilage degradation in which repair mechanisms can be studied, such as ...
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Effect of low magnitude different frequency whole body vibration on subchondral trabecular bone microarchitecture, cartilage degradation, bone/cartilage turnover, and joint pain in rabbits with knee osteoarthritis
... joint cartilage was evaluated by gross morphology, histology, and ECM gene expression level (aggrecan and type II collagen ...OC, cartilage oligometric protein, CPII, type I collagen, PIIANP, G1/G2 aggrecan ...
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Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A
... including cartilage, bone, and joint cav- ities, is highly dependent on Wnt signaling ...and cartilage degradation [21]. In the early stage of cartilage formation, it activates the ...
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Protective Effects of Many Citrus Flavonoids on Cartilage Degradation Process
... cartilage degradation. Degenerative joint disease involved degradation of joints, including articular cartilage and subchondral ...by cartilage, bone may be exposed and damaged. The ...
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Soluble biglycan: a potential mediator of cartilage degradation in osteoarthritis
... OA cartilage degradation stages) or grade IV samples with full-thickness osteochondral lesions ...OA cartilage, from very mild to ...full-thickness cartilage explants were obtained from graded ...
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Comparison of glucose derivatives effects on cartilage degradation
... porcine cartilage explants and human articular chon- drocytes (HAC) that had been induced by ...in cartilage degradation and insufficient reparative or anabolic response [14], the effects of these ...
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Type X collagen levels are elevated in serum from human osteoarthritis patients and associated with biomarkers of cartilage degradation and inflammation
... Background: Osteoarthritis (OA) is the most common degenerative joint disease, of which the pathogenesis is inadequately understood. Hypertrophy-like changes have been observed as part of the progression of OA. The aim ...
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Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin 1β mediated cartilage degradation
... of action for EPA and DHA, preliminary studies were conducted to examine the expression of catabolic inflam- matory genes at the end of the 5-day treatment period. Using well-established quantitative polymerase chain ...
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Predictive factors for the development and disease course of rheumatoid arthritis
... As- sociation of baseline levels of markers of bone and cartilage degradation with long-term progression of joint damage in patients with early rheumatoid arthritis: the COBRA stu[r] ...
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Folate targeted immunotherapy effectively treats established adjuvant and collagen induced arthritis
... To determine whether FTI could ameliorate the symptoms of experimental arthritis in rodent models, disease status was assessed by monitoring changes in limb volume/ankle diame- ter, radiological score (RAD score), and ...
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<p>Mechanism of Traditional Chinese Medicine in Treating Knee Osteoarthritis</p>
... As an affordable and safe treatment, the ef fi cacy of acu- puncture in treating KOA patients has been demonstrated. Several clinical trials were conducted in USA, Germany, Spain, and China which proved high effectiveness ...
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CCL2 and CCR2 regulate pain-related behaviour and early gene expression in post-traumatic murine osteoarthritis but contribute little to chondropathy
... Our joint structure results were limited to cartilage degradation scores and excluded detailed bone analysis. Osteophytes were present in both Ccl2 / and Ccr2 / joints post DMM (data not shown). In Ccr2 / ...
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Effect of celastrol on bone structure and mechanics in arthritic rats
... and cartilage degradation To further elucidate the protective effect of celastrol on inflammation-mediated joint damage, bone and carti- lage degradation markers were ...
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Review Article The potential role of sclerostin in the development of osteoarthritis
... and cartilage homeostasis ...induce cartilage degradation by upregu- lating matrix metalloproteinases (MMPs) and aggrecanases ...articular cartilage degrada- tion via up-regulation of ...
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Early Arthritics
... It was interesting to note the comparison between the antibodies studied and the cartilage degradation marker investigated. Among patients who developed rheumatoid arthritis at 6 months it was determined ...
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Systemic factors, structural biomarkers and vitamin D treatment in knee osteoarthritis
... reduced cartilage synthesis and increased cartilage degradation marker in knee OA ...articular cartilage by up-regulating the tissue metalloproteinase in- hibitor (TIMP-2) and decreasing IL-1β ...
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Biomarkers, type II collagen, glucosamine and chondroitin sulfate in osteoarthritis follow-up: the “Magenta osteoarthritis study”
... of cartilage in OA is characterized by two phases: a biosynthetic phase during which the cells resident in cartilage, the chondrocytes, attempt to repair the dam- aged extracellular matrix; and a ...
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Relationships amongst osteoarthritis biomarkers, dynamic knee joint load, and exercise: results from a randomized controlled pilot study
... articular cartilage degradation and synthesis with measures of knee joint load during walking, and 2) examine changes in these biomarkers following 10 weeks of strengthening ...serum cartilage ...
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