Casein Kinase-II
The Human Cytomegalovirus Virion Possesses an Activated Casein Kinase II That Allows for the Rapid Phosphorylation of the Inhibitor of NF-κB, IκBα
... virus-associated kinase. Casein kinase II (CKII) was detected in HCMV virions ...protein kinase (3, 41) that was identified as having multiple target substrates, including I B ␣ (5, ...
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Rotavirus NSP1 Requires Casein Kinase II Mediated Phosphorylation for Hijacking of Cullin RING Ligases
... ABSTRACT The rotavirus nonstructural protein NSP1 repurposes cullin-RING E3 ubiqui- tin ligases (CRLs) to antagonize innate immune responses. By functioning as substrate adaptors of hijacked CRLs, NSP1 causes ...
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Phosphorylation of the Nuclear Form of Varicella-Zoster Virus Immediate-Early Protein 63 by Casein Kinase II at Serine 186
... for casein kinase II ...that casein kinase II phosphorylation of S186 occurs in the nucleus and possibly identifying an initial molecular event operative in VZV ...
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Phosphorylation of RIG-I by Casein Kinase II Inhibits Its Antiviral Response
... Dephosphorylation of threonine at aa 770 and serine at aa 854 to 855 results in the activation of RIG-I. Based on bioin- formation analysis, there are several potential CK2 sites in RIG-I, one site at aa position 162 of ...
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Functional implications of mutations within polyomavirus large T antigen Rb-binding domain: effects on pRb and p107 binding in vitro and immortalization activity in vivo.
... the casein kinase II consensus phosphorylation region flanking the Rb-binding domain, or the deletion of amino acids 256 to 272, increased the immortalizing activity of the mutant polyomavirus large ...
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Casein kinase II and protein kinase C modulate hepatitis delta virus RNA replication but not empty viral particle assembly.
... and kinase inhibitor experiments, the phosphorylation levels of both HDAgs were diminished by the inhibitor of casein kinase II ...protein kinase C (PKC) inhibitor, suggesting different ...
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Minimal truncation of the c-myb gene product in rapid-onset B-cell lymphoma.
... N-terminal casein kinase II sites was only weakly oncogenic at 10 weeks, the minimally truncated myb virus induced a high incidence of rapid-onset tumors, including B-cell lymphomas, sarcomas, and ...
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Casein Kinase II Motif-Dependent Phosphorylation of Human Papillomavirus E7 Protein Promotes p130 Degradation and S-Phase Induction in Differentiated Human Keratinocytes
... The E7 proteins of human papillomaviruses (HPVs) promote S-phase reentry in differentiated keratinocytes of the squamous epithelia to support viral DNA amplification. In this study, we showed that nuclear p130 was ...
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The Phosphoprotein of Rabies Virus Is Phosphorylated by a Unique Cellular Protein Kinase and Specific Isomers of Protein Kinase C
... protein kinase(s) present in cell extract prepared from rat ...heparin-sensitive kinase was not the ubiquitous casein kinase II present in a variety of cell ...protein kinase C ...
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Upregulation of the Chemokine (C-C Motif) Ligand 2 via a Severe Acute Respiratory Syndrome Coronavirus Spike-ACE2 Signaling Pathway
... Ang II and induces vasoconstriction, whereas ACE2 cleaves Ang II to Ang-(1-7) and induces vaso- dilation and ...protein kinase C (PKC), protein kinase A, and casein kinase ...
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Casein Kinase 2-Mediated Phosphorylation of Respiratory Syncytial Virus Phosphoprotein P Is Essential for the Transcription Elongation Activity of the Viral Polymerase; Phosphorylation by Casein Kinase 1 Occurs Mainly at Ser215 and Is without Effect
... In our second approach, we investigated the phosphoryla- tion status of P following abrogation of CK2. Although CK2- mediated phosphorylation of RSV P can be inhibited by chem- ical inhibitors such as heparin in vitro ...
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Novel Insights into the Molecular Mechanisms Governing Mdm2 Ubiquitination and Destruction
... vitro kinase assays, we demonstrated that the major CKI phosphorylation sites are located in the Mdm2 acidic domain (p2), while other minor CKI sites are located in the N-terminal DSG site (p1) and the C-terminal ...
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Assessment of structure and component mobility within Mozzarella cheese : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy (PhD) in Food Technology at Massey University, Manawatu campus, New Zealand
... Following this initial curvature, the complex viscosity continues to decrease in a roughly linear manner with increasing temperature until reaching approximately the temperature where the cheese began to flow, where the ...
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Original Article Aberrant expression of casein kinase 1δ (CK1δ) in cervical squamous cell carcinoma
... Abstract: Cervical cancer is one of the most common gynecological carcinoma, which seriously threaten the life and health of women globally. Previous studies have shown that β-catenin abnormalities in the expression and ...
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Casein kinase 1α–dependent feedback loop controls autophagy in RAS driven cancers
... “rogue” kinase (36), as its catalytic activity appears to be ...essential kinase-stimulatory cofac- tors of multiple CK1 isoforms, including CK1α ...
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Casein kinase I epsilon somatic mutations found in breast cancer cause overgrowth in Drosophila
... ABSTRACT We are using a candidate gene approach to identify genes contributing to cancer through somatic mutation. Somatic mutations were found in breast cancer samples in the human casein kinase I epsilon ...
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Mechanism and evolution of cytosolic Hedgehog signal transduction
... Hh signal transduction in mammals utilizes the primary cilium, an evolutionarily conserved microtubule-based organelle analogous to the flagella found in single-celled eukaryotes, such as Chlamydomonas reinhardtii ...
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Varicella-zoster virus Fc receptor gE glycoprotein: serine/threonine and tyrosine phosphorylation of monomeric and dimeric forms.
... Protein tyrosine kinases phosphorylate tyrosine residues on proteins in a stable yet reversible modification. Protein ty- rosine kinase activity has been detected in all animal cells and has been detected in ...
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The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix.
... serine kinase exhibits decreased levels of MA serine ...serine/threonine kinase, the binding of which also de- pends on an arginine residue at position 106 of HIV-1 Nef ...
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Casein Kinase 1α Mediates the Degradation of Receptors for Type I and Type II Interferons Caused by Hemagglutinin of Influenza A Virus
... no kinase(s) has been reported to phosphorylate IFNGR1 for the degradation ...MAP kinase, which mediates the priming phosphorylation of IFNAR1 at ...the casein kinase family, which is capable ...
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