Cathepsin D
Docking of Cathepsin D with New Compounds
... Abstract: Cathepsin D is a lysosomal protein belongs to aspartic protease ...with cathepsin d protein. Crystal structure of cathepsin D (1LYW) was extracted from ...of ...
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Influence of methylprednisolone of the sequential redistribution of cathepsin D and other lysosomal enzymes during myocardial ischemia in rabbits
... preparations cathepsin D appeared to have diffused from lysosomes into the cytosol of injured ...of cathepsin D and the other hydrolases in ischemic ...of cathepsin D rose to ...
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TNF induced cleavage of HSP90 by cathepsin D potentiates apoptotic cell death
... Proteolysis is a major hallmark of apoptotic cell death. It is well established that besides caspases, also lysosomal cathepsin proteases are involved in apoptosis signalling. One prominent member is ...
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Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
... α-synuclein (α-syn) is a main component of Lewy bodies (LB) that occur in many neurodegenerative diseases, including Parkinson's disease (PD), dementia with LB (DLB) and multi-system atrophy. α-syn mutations or ...
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Prognostic Impact of Cathepsin D Expression in Pancreatic Cancer– A Study of 50 Cases.
... B and cathepsin D were also detected in their study. Cathepsins are nothing but lysosomal proteolytic enzymes which is present in most of the mammalian cells. In different solid cancers , Cathepsins B and ...
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Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid- derived suppressor cells
... to cathepsin to activate their enzymatic activity [46, ...activate cathepsin B to degrade xIAP to induce caspase-dependent apoptosis ...of cathepsin B and cathepsin D diminished ...
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Immunoexpression of Cathepsin D and S100A4 Protein and Their Molecular Subtyptes in Canine Mammary Carcinomas
... as Cathepsin D (CD) [2] and S100A4 pro- tein [3] revealed to be important to the metastatic process of breast cancer in humans, consequently being classified as metastasis-related ...
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CATHEPSIN D LEVEL IN THE HUMAN GINGIVAL TISSUES AND SERUM OF PERIODONTITIS SUBJECTS
... Statistical Analysis: The data are presented as mean ± SD (standard deviation). An unpaired Student’s t test was used to evaluate the significance of differences, accepting P <0.05 as the level of significance. ...
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Original Article Cathepsin D as a new allergen from Dermatophagoides farinae
... thepsin D. This indicates that cathepsin D has the ability of binding IgE in the serum of al- lergic ...of cathepsin D, ELISA was per- formed using the serum of allergic ...the ...
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Increased cathepsin D protein expression is a biomarker for osteosarcomas, pulmonary metastases and other bone malignancies
... and Cathepsin D (CTSD) were further validated by Western Blot in cell lines while the latter one showed higher expression differences also in cytospins and in clinical samples using tissue microarrays ...
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A Comparative Study of Cathepsin D Expression in Peripheral and Central Giant Cell Granuloma of the Jaws by Immunohistochemistry Technique
... that Cathepsin D affected the activity of MMP-9 in cells; therefore, use of Pepstatin A, the inhibitor of Cathepsin D, in vitro (similar to the specific inhibitor of MMP-9) resulted in ...
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Lack of association between cathepsin D C224T polymorphism and Alzheimer’s disease risk: an update meta-analysis
... The relevant studies were identified by searching PubMed, Embase, Web of Science, Google Scholar and Wan fang electronic databases in July 2013 for all the articles regard- ing the correlation between CTSD C224T ...
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11-4-2015 12:00 AM The Development and Validation of a Molecular Imaging Probe Targeted to Cathepsin D for the In-vivo Detection of Alzheimer Disease
... Background: Currently there is no widely accepted test to diagnose AD. The involvement of the lysosomal system in Alzheimer’s disease (AD) progression provides an opportunity to develop associated biomarkers. The ...
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High levels of cathepsin D and cystatin B are associated with increased risk of coronary events
... of cathepsin D, cystatin B and, to a lesser extent, cathepsin L, were associated with increased risk of future ...MDC-CC, cathepsin D levels were signi fi cantly increased in individuals ...
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Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo
... 7C, D) and basal ganglia of infants with congenital ...of Cathepsin D exhibit accumulation of phosphorylated α-synuclein in cingulate cortex Figure ...
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Mannose 6-phosphate independent targeting of cathepsin D to lysosomes in HepG2 cells
... Effect of Protease Inhibitors on Membrane Association- Our previous study on normally glycosylated cathepsin D (Rijnboutt et al., 1991) together with the present dat[r] ...
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Neutral Proteases and Cathepsin D in Human Articular Cartilage
... Proteolytic enzymes have been studied in extracts of human articular cartilage by the use of micromethods. The digestion of hemoglobin at pH 3.2 and of cartilage proteoglycan at pH 5 was shown to be due chiefly to ...
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A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci
... Cathepsin D, a lysosomal protease, can induce apoptosis when it is activated and released into the cytosol ...2A, cathepsin D, the most abundant cathepsin in differentiated macrophages ...
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The Action of Cathepsin D in Human Articular Cartilage on Proteoglycans
... cathepsin D-type enzyme activity was present in two to three times greater amounts in yellowish or ulcerated articular cartilage from patients with primary osteoarthritis than in control “normal” human ...
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Altered distribution of lysosomal cathepsin D in ischemic myocardium
... observed in control myocytes was replaced by bright fluorescent patches composed of large granules. Many of these structures displayed prominent halos of diffuse fluorescent staining in the neighboring myocytic ...
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