CCN2/CTGF
New strategy to control cell migration and metastasis regulated by CCN2/CTGF
... that CCN2/CTGF induced spherical cell aggregates formation when added to MvLu1 and P19 cells ...to CCN2/CTGF was developed by using anti-Flag conjugated agarose beads pre-incubated with ...
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Effect of connective tissue growth factor (CCN2/CTGF) on proliferation and differentiation of mouse periodontal ligament-derived cells
... of CCN2/CTGF in other mesenchymal tis- sues have been uncovered as ...that ccn2/ctgf was highly expressed in hyper- trophic chondrocytes in growth cartilage and human chondrocytic HCS-2/8 ...
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Anti connective tissue growth factor (CTGF/CCN2) monoclonal antibody attenuates skin fibrosis in mice models of systemic sclerosis
... targeting CTGF in SSc has not been fully ...of CTGF blockade in a preclinical model of SSc using two approaches: smooth muscle cell fibroblast-specific deletion of CTGF (CTGF knockout (KO)) or ...
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Prostaglandin E2 regulates the expression of connective tissue growth factor (CTGF/CCN2) in human osteoarthritic chondrocytes via the EP4 receptor
... development, CTGF is strongly expressed in the mesenchyme, including in hypertrophic chondrocytes, and plays an essential role in endochondral ossification by promoting angiogenesis, proliferation, and ...
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CCN family member 2/connective tissue growth factor (CCN2/CTGF) is regulated by Wnt–β catenin signaling in nucleus pulposus cells
... DNA; CTGF: Connective tissue growth factor; ERK: Extracellular signal-regulated pro- tein kinase; FBS: Fetal bovine serum; GAPDH: Glyceraldehyde 3-phosphate dehydrogenase; IL: Interleukin; IVD: Intervertebral ...
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Comparable response of ccn1 with ccn2 genes upon arthritis: An in vitro evaluation with a human chondrocytic cell line stimulated by a set of cytokines
... of CCN2/ CTGF (GenBank accession ...ccn1, ccn2, and β-actin were prepared with serially diluted plasmid DNAs containing the target sequences, which were amplified and evaluated simulta- neously in ...
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Evaluation of matricellular proteins as potential therapeutics for the treatment of human chronic skin wounds
... studied CCN2 as a therapeutic for aiding in tissue ...2007a). CCN2 loaded fibrin glue has been shown to enhance meniscal repair by increasing Col1a1, Col2a1 and Vegfa mRNA in the avascular zone of rabbit ...
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Development Of Granulation Tissue Mimetic Scaffolds For Skin Healing
... 61/CCN1), CTGF (connective tissue growth factors/CCN2) and NOV (nephroblastoma overexpressed/CCN3) ...healing, CCN2 is released by platelet α-granules and acts synergistically with TGF-β to promote ...
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CCN Proteins in Metastatic Melanoma
... 2013). CCN2 (formerly known as connective tissue growth factor, CTGF) is a member of the CCN family of matricellular proteins, which act primarily in two ways; by directly binding to adhesion receptors like ...
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Serum connective tissue growth factor is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis
... [9]. CTGF plays an important role in many physiological and pathological activities [10], such as inflammation, angiogenesis, wound healing, fibrosis, carcinogenesis, and tumor development ...that CTGF ...
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A structural approach to the role of CCN (CYR61/CTGF/NOV) proteins in tumourigenesis
... In primary human breast carcinomas elevated levels of CCN1, CCN2, and CCN4, but not CCN3 were associated with more advanced features [11]. Increased CCN1 pro- tein expression was observed in a large number of ...
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Interleukin-1 has opposing effects on connective tissue growth factor and tenascin-C expression in human cardiac fibroblasts.
... notably CCN2; also known as connective tissue growth factor, CTGF), osteonectin (SPARC), osteopontin (SPP1), tenascin-C (TNC), tenascin-X, periostin and galectin (Frangogiannis, ...
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... or CTGF is a matricellular protein of the CCN family of Extracellular Matrix (ECM)-associated heparin-binding proteins ...[1]. CTGF fulfils several crucial functions in biological arena including ...
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Investigating the Fibroblastic Origin of Skin-Derived Precursors and the Role Of CCN2 as a Mediator of Myofibroblastic Differentiation
... protein (25 μg) were brought to an equal volume with RIPA buffer, mixed with 6x loading dye (Thermo Scientific) and boiled at 99°C for 5 minutes. Protein mixtures were subsequently loaded onto 10x sodium dodecyl sulfate ...
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Increased fibroblast functionality on CNN2-loaded titania nanotubes
... the CCN2 coating were higher than the other two ...the CCN2-coated nanotubular surface, the cytoskeleton was formed faster for these cells than for those reacting to control ...the CCN2-coated ...
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(Z) 1,1 Dicyano 2 (4 fluorophenyl) 3 (1 hexylpyridin 1 ium 4 yl)prop 2 en 1 ide
... The title compound I crystallizes as a zwitterion in which the negative charge on the dicyanomethanide –CCN2 group and the positive charge on the N atom in the pyridinium ring.. The bond[r] ...
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CTGF Contributes to the Development of Posterior Capsule Opacification: an in vitro and in vivo study
... that CTGF promotes the migration and proliferation of HSCs and hepatoma carcinoma cells ...glaucoma, CTGF promotes the migration of human Tenon’s capsule fibroblasts, which could be blocked by paclitaxel ...
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Regulatory Mechanism of MicroRNA 145 in the Pathogenesis of Acute Aortic Dissection
... inhibitor, CTGF siRNA, or both miR- 145 inhibitor and CTGF ...while CTGF siRNA enhanced cell viability. Also, CTGF siRNA could reverse the inhibitory effect of miR-145 inhibitor on VSMC ...
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Original Article Expression of CTGF and BMP7 in experimental murine biliary atresia
... [26-32]. CTGF and BMP7 are both im- portant factors in the of TGFβ pathway. CTGF is an important factor in promoting myofibroblast differentiation and enhancing ECM synthesis, while BMP7 is an important ...
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Harnessing endogenous stem/progenitor cells for tendon regeneration
... ml CTGF were trypsinized and washed with ice-cold PBS. Cellular protein was extracted in RIPA Lysis Buffer (Thermo Fisher Scien- tific Inc.) with Protease/Phosphatase Inhibitor Cocktail (Cell Sig- naling ...
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