CD21/CR2
Relative Impact of Complement Receptors CD21/35 (Cr2/1) on Scrapie Pathogenesis in Mice
... (FDCs). CD21 helps activate B cells as part of the B cell core- ceptor with CD19 and ...mouse Cr2 gene generates isoforms with both shared and unique complement binding capaci- ties and cell-type ...of ...
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Soluble recombinant CR2 (CD21) inhibits Epstein-Barr virus infection.
... A EBV-containing B95-8 culture supernatant was incubated with various amounts of purified recombinant CR2 prior to the addition of 6 x 105 human peripheral blood mononuclear cells.. The [r] ...
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Molecular Basis of the Interaction between Complement Receptor Type 2 (CR2/CD21) and Epstein-Barr Virus Glycoprotein gp350
... of CR2 SCR1-2 DNA were produced from wild-type MBP-CR2 SCR1-2 DNA by utilizing a QuikChange site-directed mutagenesis kit (Stratagene) ac- cording to the manufacturer’s ...mutant CR2 SCR1-2 insert ...
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Inhibition of Epstein-Barr virus infection in vitro and in vivo by soluble CR2 (CD21) containing two short consensus repeats.
... However, further attempts to express truncated forms of the extracellular domain of CR2 in insect cells in order to analyze the ligand binding region of the receptor resulted in proteins[r] ...
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Complement-mediated binding of naturally glycosylated and glycosylation-modified human immunodeficiency virus type 1 to human CR2 (CD21).
... In the absence of complement i.e., heat-inactivated human serum, little binding to MT-2, Raji-3 or CEM cells was detected when untreated or swainsonine-treated virus preparations were us[r] ...
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Activation of CD21 and CD23 Gene Expression by Kaposi's Sarcoma-Associated Herpesvirus RTA
... activate CD21 (CR2, EBV receptor) gene expression and repress immunoglobulin (Ig ) expres- sion, whereas EBNA2, but not NIC, activates CD23a gene expression ...
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CD21-Dependent Infection of an Epithelial Cell Line, 293, by Epstein-Barr Virus
... of CD21 and/or its mRNA and were able to bind EBV at the cell surface, but EBV binding was not shown to be dependent on CD21 ...surface CD21 would be suffi- cient to support uptake of EBV by these ...
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Determination of the role for CD21 during Epstein-Barr virus infection of B-lymphoblastoid cells.
... Our results demonstrate first, that two discontinuous amino acid substitutions within the ligand-binding domain of murine CR2 render it capable of mediating EBV infection of human B-lymp[r] ...
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Molecular Structure and Expression of Anthropic, Ovine, and Murine Forms of Complement Receptor Type 2
... for CR2 (CD21) and serves as a means of targeting antigen or immune complexes to cells ex- pressing CR2, linking complement activation to B-cell biology and tolerance ...
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Characterization of a T-lymphocyte Epstein-Barr virus/C3d receptor (CD21).
... Internal amino acid sequences derived from tryptic peptides and a partial cDNA clone demonstrates that EBV CR2 EBVR-CR2 is homologous to complement receptor type 1 CR1 19, 54, which plac[r] ...
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Deficiency of complement receptors CR2/CR1 in Cr2 -/-mice reduces the extent of secondary brain damage after closed head injury
... that Cr2 -/- mice, which lack the receptors CR2/CD21 and CR1/CD35 for complement C3-derived activation fragments, are protected from adverse sequelae of experimental closed head ...and Cr2 -/- ...
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Stable transfection of Epstein-Barr virus (EBV) nuclear antigen 2 in lymphoma cells containing the EBV P3HR1 genome induces expression of B-cell activation molecules CD21 and CD23.
... These results demonstrate that there is an increase in the amount of CR2 and CD23 steady-state RNAs in clones expressing EBNA2 compared with the amount in BL41/P3HR1 parental cells or cl[r] ...
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A Somatic Knockout of CBF1 in a Human B-Cell Line Reveals that Induction of CD21 and CCR7 by EBNA-2 Is Strictly CBF1 Dependent and that Downregulation of Immunoglobulin M Is Partially CBF1 Independent
... 53). CD21, the complement receptor 2, is part of the B-cell receptor complex and a ligand for CD23 ...(12). CD21 promoter reporter constructs are activated by EBNA-2, but the relevant EBNA-2 response ...
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Optimal Long-Term Humoral Responses to Replication-Defective Herpes Simplex Virus Require CD21/CD35 Complement Receptor Expression on Stromal Cells
... Additional experiments will be required to identify the viral proteins recognized by the late/enhanced IgG responses. The predominance of these responses in purified virion lysates, however, indicates that they may be ...
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Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3 positive T regulatory cells in a murine model
... showing gated CD1d- CD19+ B cells from infected mice compared with whole CD19+... population from uninfected mice and isotype control for expression of CD23, CD21,.[r] ...
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Analysis of Host Gene Expression Changes Reveals Distinct Roles for the Cytoplasmic Domain of the Epstein-Barr Virus Receptor/CD21 in B-Cell Maturation, Activation, and Initiation of Virus Infection
... lack CD21 (and also CD35), estab- lished clones, and engineered the respective cloned lines to express either full-length CD21 (referred to as CR), CD21 de- void of the cytoplasmic domain (referred ...
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Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection
... of CR2-Crry and Crry-Ig in a mouse model of ...for CR2-Crry. Thus, although a therapeutic dose of CR2-Crry only minimally affects serum complement activity, there remains the potential for ...
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Conserved Region CR2 of Epstein-Barr Virus Nuclear Antigen Leader Protein Is a Multifunctional Domain That Mediates Self-Association as well as Nuclear Localization and Nuclear Matrix Association
... (iii) Mutations in EBNA-LP CR2 and CR3, which are crit- ical for self-association of the protein, abolished its cooperative transcriptional activation with EBNA-2 (33, 52). At present it is unknown whether there ...
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Effect of Impurity Sulfur on the Formation of Cr2O3 and SiO2 at the Early Stage of Steam Oxidation in both Ferittic and Austenitic Steels
... For example, it is reported that a protective Cr2 O3 layer is formed on the surface of austenitic steel SUS430 at early stage of oxidation in H2 O containing atmosphere at 1473 K, follow[r] ...
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Optimization of Resistance Spot Welding Process Parameters for CR2 513 Material using Taguchi Method
... Resistance spot welding (RSW) process is a major sheet metal joining processes. Used in Automobile, Aerospace and Home appliances Industries. Because it has the advantage of high speed operation, high-production assembly ...
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