CD4 and CD8 T cells
ts1, a temperature-sensitive mutant of Moloney murine leukemia virus TB, can infect both CD4+ and CD8+ T cells but requires CD4+ T cells in order to cause paralysis and immunodeficiency.
... In some experiments, a specific subset of T cells was depleted in vivo by intraperitoneal administration of 0.5 mg of anti-CD4 for CD4+ T cells or anti-CD8 for CD8+ T cells antibodies on[r] ...
8
CD4+ T Cells Develop Antiretroviral Cytotoxic Activity in the Absence of Regulatory T Cells and CD8+ T Cells
... that CD8 ⫹ T cells are es- sential in controlling FV infection ...target cells is critical for retroviral immu- ...of CD4 ⫹ T cells during acute FV infection results ...
8
Increased production of soluble CTLA 4 in patients with spondylarthropathies correlates with disease activity
... on T cells and its ligands, CD80 and CD86, present on the antigen presenting cells (APC) are the proto- typical costimulatory molecules ...Cytotoxic T lymphocyte associated molecule-4 (CTLA-4 ...
11
Divergent Kinetics of Proliferating T Cell Subsets in Simian Immunodeficiency Virus (SIV) Infection: SIV Eliminates the “First Responder” CD4+ T Cells in Primary Infection
... ⫹ T cells were CCR5 ⫹ (data not shown), suggesting that they are potential targets for direct infection with transmitted founder ...SIV-infected cells in tissues coex- pressed BrdU in tissue sections ...
7
Route of antigen delivery impacts the immunostimulatory activity of dendritic cell-based vaccines for hepatocellular carcinoma
... epithelial cells, activated lymphocytes and tumor cells, has been observed [14–17], although a specific cell sur- face receptor has not yet been definitively identified ...both CD4+ and CD8+ ...
16
Suppression of antitumor immunity by IL 10 and TGF b producing T cells infiltrating the growing tumor: influence of tumor environment on the induction of CD4+ and CD8+ regulatory T cells
... natural CD4 ⫹ CD25 ⫹ T cells may play a critical role in progression of a number of cancers (2, 9, ...of CD4 ⫹ CD25 ⫹ Treg cells in the peripheral blood of cancer patients, and this is ...
9
Application of rapid in vitro co culture system of macrophages and T cell subsets to assess the immunogenicity of dogs vaccinated with live attenuated Leishmania donovani centrin deleted parasites (LdCen−/−)
... ated cells and eventual cell death of amastigote forms while the growth of promastigote forms is ...activated CD4 + and CD8 + T-cells, IFN- γ production by CD8 + ...
10
CD4 T Cells Promote CD8 T Cell Immunity at the Priming and Effector Site during Viral Encephalitis
... glia cells, including oligo- dendrocytes, upregulate MHC class I and have the capacity to directly trigger CD8 T cell effector ...However, CD4 T cells are likely engaged only by ...
12
Nef functions in BLT mice to enhance HIV 1 replication and deplete CD4+CD8+ thymocytes
... depletes CD4 + T cells in blood and tissues. CD4 + CD8 + thymocytes were also efficiently depleted but CD4 + CD8 - thymocytes were partially resistant to cell killing by ...
15
Cognate CD4 T-Cell Licensing of Dendritic Cells Heralds Anti-Cytomegalovirus CD8 T-Cell Immunity after Human Allogeneic Umbilical Cord Blood Transplantation
... by T lym- phocytes. In particular, CD8 ⫹ cytotoxic T lymphocytes (CTLs) fulfill a predominant role in protection against CMV disease (2– ...cognate CD4 ⫹ T-cell licensing (7–10). ...
12
Immunosenescence in the nursing home elderly
... in CD4+ T-cells in the elderly have been far more inconsistent than for CD8+ ...higher CD4+ T-cells [25,26] and lower CD4+ T-cells ...lower ...
9
Analysis of Apoptosis of Memory T Cells and Dendritic Cells during the Early Stages of Viral Infection or Exposure to Toll-Like Receptor Agonists
... memory CD8 and CD4 T cells occurs early during many ...to T cell loss rather than ...of T cells ex vivo for activated caspases but with only low levels of ex vivo staining ...
13
Role of Interferon Regulatory Factor 7 in T Cell Responses during Acute Lymphocytic Choriomeningitis Virus Infection
... and CD8 ⫹ T cells) specific for a single CD8 epitope (17, ...both CD8 ⫹ and CD4 ⫹ T cells has an intrinsic role for T cell activation and survival (17, ...
12
Interleukin-2 Therapy Induces CD4 Downregulation, Which Decreases Circulating CD4 T Cell Counts, in African Green Monkeys
... downregulate CD4 expression on AGM T cells in vitro and may be important in driving the generation of the CD8 ␣␣ T cell pool, a population that displays functional similarity to ...
9
Simultaneous inhibition of JAK and SYK kinases ameliorates chronic and destructive arthritis in mice
... of CD8 + T cells and neu- trophils (not shown) were comparable among healthy and treated ...NK cells was already observed after 6 days of treatment (not shown) and is in accordance with the ...
19
IL 17A secretion by CD8+ T cells supports Th17 mediated autoimmune encephalomyelitis
... against CD4 (clone YTS191) or CD8 (clone YTS169) or control immu- noglobulin (rat ...LN cells, splenocytes, and CNS lymphocytes was performed as previously described ...CNS cells (pooled from ...
15
Decreased CD8+T cell response to Epstein-Barr virus infected B cells in multiple sclerosis is not due to decreased HLA class I expression on B cells or monocytes
... 35. Ferreira MAR, Mangino M, Brumme CJ, Zhao ZZ, Medland SE, Wright MJ, Nyholt DR, Gordon S, Campbell M, McEvoy BP, Henders A, Evans DM, Lanchbury JS, Pereyra F, International HIV Controllers Study, Walker BD, Haas DW, ...
6
CD19 CAR–T cells of defined CD4+:CD8+ composition in adult B cell ALL patients
... CAR–T cells) has produced a high rate of complete remission (CR) in adult and pediatric patients with relapsed and refractory B cell acute lymphoblastic leukemia (B-ALL) in small phase I clinical trials ...
17
Peripheral blood CD4+CD25+CD127low regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: increase in regulatory T cells correlates with clinical response
... mononuclear cells (PBMCs) were ob- tained at baseline and at weeks 24 and 52 of TCZ treat- ...Thawed cells were stained for 30 minutes at room temperature under darkened conditions with the following ...
10
Fetal thymus graft enables recovery from age-related hearing loss and expansion of CD4-Positive T cells expressing IL-1 receptor type 2 and regulatory T Cells
... of T-cell dysfunction, hearing loss, and SG neuron de- generation in the mice aged 6 months old were recov- ered from at 12 months old after the thymus transplants had been applied twice ...of T-cell func- ...
10