CD4+ and/or CD8+ T-cell epitopes
Identification of Hexon-Specific CD4 and CD8 T-Cell Epitopes for Vaccine and Immunotherapy
... overlapping CD4 ⫹ and CD8 ⫹ T-cell epitopes has previously been described for the tumor setting where MART-1-specific CD8 ⫹ T cells recognize the HLA-A2- restricted ...
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Profiling the immune vulnerability landscape of the 2019 Novel Coronavirus
... abundant CD4 T cell epitopes, CD8 T cell epitopes, and linear antibody epitopes, in each of the three ...the CD8 epitope-enriched regions are higher ...
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Characterization of Homologous and Heterologous Rotavirus-Specific T-Cell Responses in Infant and Adult Mice
... specific T-cell responses, several new approaches have been developed which offer advantages compared to more traditional tech- niques like classic cytotoxicity and proliferation ...virus-specific T ...
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Mapping of positive selection sites in the HIV 1 genome in the context of RNA and protein structural constraints
... to T and C to G substitutions which had equal rates), and crossed this with the MG94 model to obtain a codon substitution ...http://www.rcsb.org/pdb/home/home.do. CD8 T cell, CD4 ...
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Clinical implications of Epstein-Barr virus strain diversity
... virus-specific CD4+ and CD8+ T-cell epitopes, and of holes in the individual T-cell repertoire against epitopes derived from strain variants, may suggest that ...
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Differential Antigen Presentation Kinetics of CD8+ T-Cell Epitopes Derived from the Same Viral Protein
... ⫹ T cells, were able to present CD8 ⫹ T-cell epitopes derived from Gag proteins in the incoming virus particle ...that CD4 ⫹ T cells lack the anti- gen processing ...
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Identification of Cross-Reactive Norovirus CD4+ T Cell Epitopes
... induced CD4 ⫹ IFN- ␥ re- sponses in Peyer’s patches and spleen (22, ...of CD8 ⫹ T cells and secretion of the TH2 cytokine IL-4 were separately noted; however, it is unclear if these responses were ...
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Chimeric murine polyomavirus virus-like particles induce Plasmodium antigen-specific CD8+ T cell and antibody responses
... the epitopes presented by the chimeric VLP co-administered with 50 µg of high molecular weight poly (I:C) adjuvant (Invivogen, USA) were included as comparator groups in each ...ovalbumin CD8 + 257 − 264 ...
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CD19 CAR–T cells of defined CD4+:CD8+ composition in adult B cell ALL patients
... CAR–T cell infusions. Five patients treated in our study with CAR–T cells after Cy-based lymphodepletion had persistent leu- kemia or subsequently relapsed and received a second infusion of ...
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HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes
... toward CD8 ⫹ T-cell targeting as a causal mechanism behind HLA-medi- ated control (reviewed in reference 4), it has been difficult to prove this ...immunodominant epitopes by the protective ...
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Combination of Immune and Viral Factors Distinguishes Low-Risk versus High-Risk HIV-1 Disease Progression in HLA-B*5701 Subjects
... HIV-1-specific CD8 ⫹ T cells ex- plains control of HIV-1 replication, evolution, or overall disease progression (42), CD8 ⫹ T cell polyfunctionality provides a mea- surable correlate of ...
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Human CD8+ and CD4+ T Cell Memory to Lymphocytic Choriomeningitis Virus Infection
... memory CD8 ⫹ T cells generated after an acute infection with live-attenuated vaccines exhibit pheno- typic and functional characteristics that are distinct from those described for human CD8 ⫹ ...
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Multiple effects of CD40–CD40L axis in immunity against infection and cancer
... a T-cell surface receptor that binds to costimulatory molecules B7-1 (CD80) and B7-2 (CD86) on APCs such as dendritic cells (DCs) and macrophages, and is involved in triggering of cell-mediated ...
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Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end organ inflammation
... The particular SNP that has been associated with hyperten- sion and other cardiovascular disorders, rs3184504, results in a substitution of tryptophan for arginine at position 262 in the pleckstrin homology domain. This ...
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CD4+ and CD8+ T cell–dependent antiviral immunity requires STIM1 and STIM2
... TNF-α. T eff cells are characterized by high expression levels of the killer cell lectin-like receptor G1 (KLRG1) and the transcription factor T-bet, but low levels of IL-7 receptor α chain (IL-7Rα ...
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Selective Lymphocyte Depletion during the Early Stage of the Immune Response to Foot-and-Mouth Disease Virus Infection in Swine
... of T-cell proliferation. We next determined whether the remaining T cells in the circulation were func- tional in inducing cellular ...the T cells to respond to concanava- lin A was greatly ...
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Human T cell recognition of the blood stage antigen Plasmodium hypoxanthine guanine xanthine phosphoribosyl transferase (HGXPRT) in acute malaria
... HGXPRT T cell proliferation in PBMC from people with acute malaria suggests that HGX- PRT is ...by T cell responses, peptides 20 amino acids in length with a 10 amino acid overlap based on the ...
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CD4+ T Cells Are Required for the Priming of CD8+ T Cells following Infection with Herpes Simplex Virus Type 1
... target cell lysis was observed in uninfected B6 mice, while HSV-1 gB-pulsed targets were completely lysed in HSV-1-infected B6 mice ...both CD4-depleted and B6-MHC-II ⫺/⫺ mice (Fig. 5A). Depletion of both ...
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Apoptosis and Regeneration of Hepatocytes during Recovery from Transient Hepadnavirus Infections
... Our results clearly showed that hepatocytes of transiently and chronically infected woodchucks undergo programmed cell death at an increased rate compared to uninfected control animals (Fig. 7A and B). We arrived ...
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Epigenome-wide association study of DNA methylation in panic disorder
... of CD4 + T cells (P = ...naive CD4 + T cell was also observed in PD ...with CD4 + T cells, an increase in CD4 + T cells might be a part of an immune ...
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