CD4(+) T cell responses
MyD88 Intrinsically Regulates CD4 T-Cell Responses
... inflammatory responses in innate immune cells, but its role in the regulation of the adap- tive immune response and immunopathology is poorly defined (6, 23, ...affect T-cell responses? The ...
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HIV-1 Antibody Neutralization Breadth Is Associated with Enhanced HIV-Specific CD4+ T Cell Responses
... HIV-specific CD4 ⫹ T cells in the develop- ment of antibody neutralization breadth, we comprehensively as- sessed a cohort of 34 chronically HIV-infected controllers for cir- culating ex vivo Gag- and ...
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Impact of Distinct Poxvirus Infections on the Specificities and Functionalities of CD4+ T Cell Responses
... contribute to the suppression and host control of ECTV replica- tion (9), consistent with the well-documented pleiotropic antivi- ral effects of grzB expression. In addition to triggering apoptosis during ECTV infection, ...
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Amelioration of experimental autoimmune encephalomyelitis by clozapine is not associated with defective CD4 T cell responses
... the T cell response ...of CD4 T cells, although this is yet to be ...reactive T cells initiate the inflammatory response in the CNS, inflammatory monocytes are recruited and their ...
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Hormonal Regulation of CD4+ T-Cell Responses in Coxsackievirus B3-Induced Myocarditis in Mice
... Th2 cell responses, usually affects younger ...with cell-mediated injury of joints, correlates with a deficiency in Th2-like cytokines ...moral responses and suppress cellular immunity (3, 9, ...
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CD4+ CD25+ Regulatory T Cells Impair HIV-1-Specific CD4 T Cell Responses by Upregulating Interleukin-10 Production in Monocytes
... of CD4 T cells to proliferate and to secrete cytokines when stimulated with recombinant HIV-1 p24 protein in the presence of an IL-10R␣-blocking antibody or an isotype ...HIV-1-specific CD4 T ...
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Bronchoalveolar CD4+ T cell responses to respiratory antigens are impaired in HIV-infected adults
... The authors observed a higher proportion of regulatory T cells in BAL fluid compared to peripheral blood in HIV-uninfected adults. Immunity in the lung is well regulated. A high degree of regulation is necessary ...
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MAVS Is Essential for Primary CD4+ T Cell Immunity but Not for Recall T Cell Responses following an Attenuated West Nile Virus Infection
... immune responses, culminating in the synthesis of antiviral cytokines, including type I interferons (IFNs) and proinflammatory cytokines ...secondary T cell responses ...immune responses ...
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Human CD8+ and CD4+ T Cell Memory to Lymphocytic Choriomeningitis Virus Infection
... ⫹ T cells generated after an acute infection with live-attenuated vaccines exhibit pheno- typic and functional characteristics that are distinct from those described for human CD8 ⫹ T cells specific for ...
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HIV Controllers Exhibit Enhanced Frequencies of Major Histocompatibility Complex Class II Tetramer+ Gag-Specific CD4+ T Cells in Chronic Clade C HIV-1 Infection
... epitope-specific responses remains a major challenge in natural infection and vaccine studies because of the tremendous complexity of CD4 ⫹ T cell ...p24-specific CD4 ⫹ T ...
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Adenovirus Serotype 5 Vaccination Results in Suboptimal CD4 T Helper 1 Responses in Mice
... investigated CD4 T cell responses induced by adenovirus ...transgene-specific CD4 T cells compared to the original ...Th1 responses following Ad5 ...induced CD4 ...
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Virus-Specific CD4+ and CD8+ Cytotoxic T-Cell Responses and Long-Term T-Cell Memory in Individuals Vaccinated against Polio
... of T cells in immunity to PV. The presence of PV- specific CD4 T cells in vaccinated individuals is well docu- mented (4, 43, 47), and virus-specific CD4 T cells are known to provide ...
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Multiple T-Cell Responses to Human Immunodeficiency Virus Type 1 Are Enhanced by Dendritic Cells
... ⫹ T-cell reactivity to single HIV-1 peptides repre- senting the minimal, optimal HLA A*0201 epitope SL9, as well as to 15-mer and 20-mer extensions of this ...⫹ T-cell responses were ...
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B7-Mediated Costimulation of CD4 T Cells Constrains Cytomegalovirus Persistence
... of CD4 T cell responses and viral load in ...CD8 T cell pool after primary infection (12, 33, 36), al- though NK control and CD8 T cell restriction of replication ...
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Glatiramer acetate (Copaxone) therapy induces CD8+ T cell responses in patients with multiple sclerosis
... GA-induced T cell ...prominent T cell proliferative responses to ...these responses are different in distinct subsets of T ...GA-induced CD4 + T cell ...
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BK Polyomavirus specific T cell immune responses in kidney transplant recipients diagnosed with BK Polyomavirus associated nephropathy
... patients, T cell-mediated immunity to BKPyV is associated with the multifunctional properties of CD4 + T cells, as both T-helper and T-cytotoxic cells, for BKPyV clearance ...
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Signature for Long-Term Vaccine-Mediated Control of a Simian and Human Immunodeficiency Virus 89.6P Challenge: Stable Low-Breadth and Low-Frequency T-Cell Response Capable of Coproducing Gamma Interferon and Interleukin-2
... of CD4 T cells, antiviral CD8 and CD4 T-cell responses, and antibody responses up to the time of euthanasia at 200 weeks ...of CD4 T ...␥ ...
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CD160 isoforms and regulation of CD4 and CD8 T cell responses
... rested T-cells (both CD4 + and CD8 + ) ex vivo likely due to the culture ...primary T-cells is more complex than initially ...upon T-cell stimulation similar to the previously described ...
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Lymphocytic Choriomeningitis Virus Infection Yields Overlapping CD4+ and CD8+ T-Cell Responses
... ␥ responses observed in the ELISPOT assays were indeed due to CD4 ⫹ T-cells, we performed ICCS ...and CD4 and CD8 surface ...mean responses against each of the peptides are shown for ...
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Public T cell receptors confer high avidity CD4 responses to HIV controllers
... Gag293-specific CD4 responses in HIV controllers and efficiently treated patients, two groups character- ized by long-term viral ...in CD4 responses were not primarily determined by lev- els ...
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