CD40/CD40L
LNFPIII/LeX-Stimulated Macrophages Activate Natural Killer Cells via CD40-CD40L Interaction
... We previously demonstrated that the neo-glycoconjugate LNFPIII-dex drives Th2-type responses in vivo, functioning as a Th2-type adjuvant for third-party antigens, and activates a population of Gr1 ⫹ F4/80 ⫹ macrophages ...
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Cigarette smoke exposure promotes differentiation of CD4<sup>+</sup>T cells toward Th17 cells by CD40-CD40L costimulatory pathway in mice
... The CD40– CD40L pathway blocked by the antagonistic CD40 antibody reduced levels of IL-27and IL-17A in our study, so blockade of CD40–CD40L ligation might mitigate heated inflamma- tory ...
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Multiple effects of CD40–CD40L axis in immunity against infection and cancer
... Later, CD40 has been found to express on B cells, macro- phages and DCs, as well as many nonimmune ...cells. CD40– CD40L signaling in B cells is important for generation of long-lived plasma cells ...
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Original Article The role of CD40 and CD40L in the pathogenesis of an experimental model of choroidal neovascularization
... the CD40-CD40L effect on local tissue inflammation and subsequent local expression level of anti-angiogenic cytokines, CD40/CD40L could reportedly affect the behavior of vascular endothelial ...
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Bürger, Christina (2017): Cell type-specific CD40-CD40L interaction in atherosclerosis. Dissertation, LMU München: Medizinische Fakultät
... of CD40 and CD40L and the crucial role of both, receptor and ligand, in T cell-dependent B cell differentiation and activation could be ...of CD40 and CD40L, by using blocking antibodies which ...
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Original Article Pathological characteristics of CD40/CD40L and NF-κB proteins related to inflammation in benign prostatic hyperplasia tissue: a retrospective study of 120 cases
... of CD40/CD40L and NF-κB proteins related to inflammation in benign prostatic hyperplasia (BPH) tissue, as well as the outcomes of ...that CD40 and CD40L were mainly expressed in prostate ...
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Melanoma immunotherapy by targeted IL 2 depends on CD4+ T cell help mediated by CD40/CD40L interaction
... and CD40L expression, ...C57BL6/J CD40L KO mice (Figure ...a CD40/CD40L–mediated ...anti- CD40L Ab blocking of CD40L interaction with CD40 (Figure ...
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Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L
... PKCs were not inhibited by Jak inhibitor (Figures 1C, D). Pretreatment with anti-CD40 antibody or CD40 siRNA significantly attenuated cytokine production and activation of signal molecules in the co-culture ...
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CD40L membrane retention enhances the immunostimulatory effects of CD40 ligation
... of CD40L monoclonal neutralizing antibody to restore cell viability in RAdnCD40L-infected cells further attributes cell death to mCD40L expression ...and CD40-CD40L interaction in mCD40L-induced cell ...
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Preeclampsia serum upregulates CD40/CD40L expression and induces apoptosis in human umbilical cord endothelial cells
... (Shanghai): CD40, forward 5’- TTGGTGGTGGTGGTGTTG-3’ and reverse 5’- GCATCTGTGTATATGGCTTCC-3’ (124 bp); CD40L, forward 5’-CCTCTGCCACCTTCTCTG-3’ and reverse 5’-TCTTCTATCTTGTCCAACCTTC-3’ (213 bp); and GAPDH, ...
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Do CD40L and CD40 contribute to sickle cell anemia?
... that CD40L is ~30 fold higher in plasma concentration of patients with SCA than in unaffected ...Correspondingly, CD40L is significantly depleted from sickle cell platelets SCA patients suffer from ...
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CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection.
... with CD40, which is present on B cells and monocytes/macrophages (26). CD40L stimula- tion of B cells results in their activation and induces survival signals which permit further ...for CD40 as a ...
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Adenovirus mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients
... Plasma proteomics showed that some proteins, such as E-selectin, CD6 and stem cell factor (SCF) that are associ- ated with immunity were altered post therapy. Adhesion molecules have an important role in cancer ...
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Marschner, Anja Kristina (2004): Immunstimulatorische Aktivität von CpG-Oligonukleotiden im Menschen und im Rhesusaffen: Aktivierung humaner Natürlicher Killer T-Zellen durch CpG-Oligonukleotide und α-Galaktosylceramid und Etablierung eines nicht-humanen Primatenmodells für präklinische Studien mit CpG-Oligonukleotiden. Dissertation, LMU München: Medizinische Fakultät
... Eine Interaktion über CD40/CD40L-Moleküle könnte im vorliegenden Modell nicht nur zwischen NKT-Zelle und Ag-präsentierender DC (MDC) stattfinden, sondern auch zwischen NKT-Zelle und PDC,[r] ...
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Role of Co-stimulation in Leishmaniasis
... in CD40 deficient mice was not directly related to the absence of CD40:CD40L interaction [23], a study on IL-12 production in DCs infected with ...on CD40 priming by activated CD40+ T ...
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Lupus nephritis: current update
... and CD40/CD40L; blockade of these co-stimulatory pathways is being tested as potential therapeutic strategies in ...studies. CD40L, CD40 ligand; ICOS, inducible T-cell costimulator; ICOSL, ...
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Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation
... of CD40 expression in mouse microglial cells by interfering with the JAK/STAT1 path- ...microglial CD40. Aberrant expression of CD40 by microglial cells, in con- junction with the release of TNF- α , ...
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Glucocorticoids upregulate CD40 ligand expression and induce CD40L dependent immunoglobulin isotype switching
... induces CD40L surface-protein expression in human PBMCs and T and B ...of CD40L. Standard staining with PE-conjugated anti- CD40L mAb revealed that HC induces a small, but reproducible, shift of the ...
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The relationship between intervention in the CD40 signal pathway and choroidal neovascularization
... B7.2, CD40 on mac- rophages than on the lung macrophages by flow cytometry, from which we inferred that T-cells and macrophages could promote the expression of VEGF through the interaction of ...
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Multimeric Soluble CD40 Ligand and GITR Ligand as Adjuvants for Human Immunodeficiency Virus DNA Vaccines
... soluble CD40L constructs do not significantly augment proliferative, cytokine, or antibody responses to DNA ...While CD40 stimulation is sufficient to activate DCs to generate CD8 ⫹ T-cell responses (70), ...
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