CD8+ T cell antiviral activity
Early Gag Immunodominance of the HIV-Specific T-Cell Response during Acute/Early Infection Is Associated with Higher CD8+ T-Cell Antiviral Activity and Correlates with Preservation of the CD4+ T-Cell Compartment
... area (FSC-A) versus height (FSC-H) was constructed to remove doublets. Then, gating was performed on small lymphocytes in a plot of FSC versus side scatter (SSC). At least 80,000 events were acquired in the lymphocyte ...
18
CD4 T Cells Promote CD8 T Cell Immunity at the Priming and Effector Site during Viral Encephalitis
... D4 T cells play critical roles in controlling viral infections by promoting CD8 T cell responses as well as humoral immu- ...primary antiviral CD8 T cell immunity ...
12
Control of Virus-Specific CD8+ T-Cell Exhaustion and Immune-Mediated Pathology by E3 Ubiquitin Ligase Cbl-b during Chronic Viral Infection
... inhibitor cell receptors, pro- teins involved in intracellular trafficking, and transcriptional repressors (6, 11, ...of activity levels of PLC- ␥ 1 and PKC- , two key factors in the TCR signaling ...of ...
16
NK T Cells Contribute to Expansion of CD8+ T Cells and Amplification of Antiviral Immune Responses to Respiratory Syncytial Virus
... killing activity, as evidenced by delayed viral ...2 T cells (71). Thus, in our model system, activation of NK T cells contributes to the amplifica- tion of protective antiviral CD8 ⫹ ...
10
Avidity of influenza specific memory CD8+ T cell populations decays over time compromising antiviral immunity
... of CD8 + T cell mediated protective immunity and impaired ex vivo T-cell ...memory CD8 + T cells was predominantly reflected by diminished degranulation and/or IFN- γ ...
9
PIIS1525001618304003.pdf
... in CD8 T cell anti- viral activity against JR-CSF HIV-infected autologous targets in an ex vivo autologous assay (VIA), although the clinical significance of this mild to modest impact is ...in ...
11
Murine Model of Interstitial Cytomegalovirus Pneumonia in Syngeneic Bone Marrow Transplantation: Persistence of Protective Pulmonary CD8-T-Cell Infiltrates after Clearance of Acute Infection
... presensitized antiviral T cells by means of cell transfer demonstrated antiviral control (38, 40) and, notably, also prevention of lung histopathology (39), mediated by CD8 T ...
12
Changes in Soluble Factor-Mediated CD8+ Cell-Derived Antiviral Activity in Cynomolgus Macaques Infected with Simian Immunodeficiency Virus SIVmac251: Relationship to Biological Markers of Progression
... noncytolytic antiviral re- sponse may play a role in controlling infection and/or prevent the development of ...This antiviral activity was detected during primary infection coinciding with or ...
10
Transcriptional and Posttranscriptional Regulation of Cytokine Gene Expression in HIV-1 Antigen-Specific CD8+ T Cells That Mediate Virus Inhibition
... antigen-specific CD8 ⴙ T cells have increased expres- sion of IFN- ␥ , MIP-1 ␣ , MIP-1 ␣ P, MIP-1  , GM-CSF, XCL1, and TNFRSF9 that correlate with virus ...of CD8 ⫹ T cells includes the ...
15
Analysis of A47, an Immunoprevalent Protein of Vaccinia Virus, Leads to a Reevaluation of the Total Antiviral CD8+ T Cell Response
... a CD8 ⫹ T cell epitope based on an amino acid sequence previously shown to detect a T cell population only when used at a high ...elicit CD8 ⫹ T cell responses at 1 ...
10
Gammaherpesvirus Persistence Alters Key CD8 T-Cell Memory Characteristics and Enhances Antiviral Protection
... that CD8 ⫹ T cells from both persistently and nonpersistently infected mice have potent an- tiviral activity, but the cells from the persistently infected mice were more effective at protecting ...
13
Efficacious Early Antiviral Activity of HIV Gag- and Pol-Specific HLA-B*2705-Restricted CD8+ T Cells
... VL9-specific CD8 ⫹ T cells in their ability to inhibit viral replication in vitro, the extent to which these differences are significant in vivo is ...individual CD8 ⫹ T- cell ...
15
Antiviral Activity of HIV gp120-Targeting Bispecific T Cell Engager Antibody Constructs
... lock HIV gp120 prior to any conformational changes. In contrast, the scFv 17b targets a CD4-inducible HIV env gp120 epitope. Thus, the dual-targeting BiTE, CD417b BiTE, combines two very nice features, i.e., binding HIV ...
13
Highly Efficient Antiviral CD8+ T-Cell Induction by Peptides Coupled to the Surfaces of Liposomes
... GP33-specific CD8 ⫹ T-cell responses of immunized ...-producing CD8 ⫹ T cells specific to GP33 were determined by intracellular IFN- ␥ ...of CD8 (x axis) with FITC-conjugated MAb ...
10
Polyomavirus-Infected Dendritic Cells Induce Antiviral CD8+ T Lymphocytes
... KLH-specific T helper cell ...MHC-restricted T cells and to possess phagocytotic activity indicates that these DC are not fully mature ...
9
Large scale analysis of pediatric antiviral CD8+ T cell populations reveals sustained, functional and mature responses
... virus-specific CD8+ cells play a crucial role in the control of HCMV replication during both acute and chronic phases ...virus-specific CD8+ T cell responses develop during primary infection ...
11
Cd8+ T Cell Effector Function And Transcriptional Regulation During Hiv Pathogenesis
... by CD8 + T cells (Migueles et ...+ CD8 + cells in CPs compared to ECs. This would suggest CD8 + T cells from the group of CPs studied here should provide superior control over HIV ...+ ...
154
Two photon imaging of intratumoral CD8+ T cell cytotoxic activity during adoptive T cell therapy in mice
... adoptive T cell therapy is ...tumor cell destruction in a model of T cell therapy (Figure 4 and Figure ...after T cell therapy in some clinical trials ...tumor cell ...
9
Transcriptional Control and Population Dynamics of Antiviral CD8+ T Cell Responses
... Two T-box transcription factors, T-bet and Eomesodermin (Eomes), have critical roles in the development of natural killer cells and the differentiation of CD8 + T cells in response to acutely ...
118
A hematopoietic contribution to microhemorrhage formation during antiviral CD8 T cell-initiated blood-brain barrier disruption
... antigen-specific CD8 T cells as an additional potent mediator of rapid BBB disruption ...that CD8 T cells and high antigenic peptide load promote an important link between inflammatory disease ...
16