Cell death and differentiation
Lapatinib induces autophagic cell death and differentiation in acute myeloblastic leukemia
... leukemia cell lines, lapatinib induced apoptosis in HL-60, NB4, and Jurkat cells, but induced nonapoptotic cell death in U937, K562, and MEG-01 ...autophagic cell death as shown by ...
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Original Article Programmed cell death 4 (PDCD4) repression is involved with tumor cell differentiation and lymph node metastasis in patients with colon cancer
... Programmed cell death 4 (PDCD4), a novel tumor suppressor, inhibits neoplastic transformation and tumor progression, and is downregulated or even lost in various types of ...poor differentiation and ...
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Developmental Coordination of Gamete Differentiation with Programmed Cell Death in Sporulating Yeast
... mother cell vacuole, which undergoes an apparent programmed ...programmed cell death (PCD) of the meiotic mother cell ...mother cell PCD is accompanied by an accumulation of depolarized ...
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The mutational landscape of recurrent versus nonrecurrent human papillomavirus–related oropharyngeal cancer
... response, cell cycle, cell death, and differentiation ...DDR, cell cycle, cell death, and differ- entiation pathway components are outlined in Supplemental Table ...
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Regulation of cellular proliferation, differentiation and cell death by activated Raf
... The survival of cells requires the presence of survival fac- tors, and the lack of this trophic support is one of the best- studied signals for induction of cell death. In Rat-1 fibrob- lasts, ...
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Intrinsic mechanisms of regulation of anti-Sm B cell anergy
... PC differentiation than non-Tg B cells ...PC differentiation are more severe for 2-12H/Vκ4 B cells than 2-12H B cells consistent with the lower levels of secreted antibody by B cells of all subsets ...PC ...
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Albumin/globulin ratio is negatively correlated with PD-1 and CD25 mRNA levels in breast cancer patients
... programmed cell death protein 1 (PD-1), cluster of differentiation 28 (CD28), cytotoxic T-lym- phocyte antigen-4 (CTLA-4), and cluster of differentiation 25 (CD25) in the peripheral blood of ...
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Botulinum neurotoxin type C protease induces apoptosis in differentiated human neuroblastoma cells
... which differentiation sensitises neuroblastomas to BoNT/C protease most likely involves the double loss of ubiquitous SNAP23 and neuron-specific SNAP25 ...to cell death in a number of cell ...
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Pathology of Cell Death
... autophagic cell death. It plays a crucial role in cell homeostasis, by controlling cell differentiation, cell survival and death especially under the conditions of ...
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Discordant Reports of miRNA Expression in Cervical Cancer: An Upshot of Overlapping Factors
... cervical cancer [11] amongst others. MicroRNAs (miRNA) act by inhibiting messenger RNA (mRNA) in several biological processes, including proliferation, differentiation, development, metabolism and cell ...
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Borna Disease Virus Infects Human Neural Progenitor Cells and Impairs Neurogenesis
... of differentiation by growth factor ...in cell death, as has been observed for another neu- rotropic virus, human cytomegalovirus, which blocks neuronal differentiation and induces apoptosis ...
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Immune contexture defined by single cell technology for prognosis prediction and immunotherapy guidance in cancer
... of differentiation; Th1: type 1 T helper; PD‑L1: programmed cell death ligand‑1; PD‑1: programmed cell death protein‑1; TIL: tumor infiltrating lymphocyte; TIM: tumor‑infiltrating ...
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Ligand activated BMP signaling inhibits cell differentiation and death to promote melanoma
... apoptotic cell death in A375 cells as well as in vivo in zebrafish melanomas and mouse xenografts (Figure 6, B and C, and Supplemental Figure 8, ...apoptotic cell death as compared with basal ...
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RelA/p65 promotes osteoclast differentiation by blocking a RANKL induced apoptotic JNK pathway in mice
... The mechanism by which JNK acti- vation leads to cell death has only been studied in the context of TNF signal- ing. Franzoso and colleagues (18, 24) have shown that RelA mediates tran- scription of ...
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Increased cell motility and invasion upon knockdown of lipolysis stimulated lipoprotein receptor (LSR) in SW780 bladder cancer cells
... transfected with AMAXA program A23 with 1.2 μ g siRNA in 100 μl AMAXA solution R (standard solution in the Amaxa system) according to the instructions of the manu- facturer. 25,000 transfected cells in a total volume of ...
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c-kit Haploinsufficiency impairs adult cardiac stem cell growth, myogenicity and myocardial regeneration
... single cell) were transplanted through the systemic circulation by tail vein injection, into 16-week-old syngeneic male C57BL/ 6J mice with ISO + 5-FU failing cardiomyopathy 21 ...
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A multiscale analysis of drug transport and response for a multiphase tumor model
... comprise exchange of mass and momentum via reaction processes regulated by a passive solute and interphase drag, respectively. In subsequent works additional phases have been added to incorporate tumour vasculature, and ...
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The intracellular domain of β-dystroglycan mediates the nucleolar stress response by suppressing UBF transcriptional activity
... Fig. 4 Silencing of dystroglycan results in altered nucleoli structure and reduced levels of B23 and UBF. a Messenger RNA expression of dystroglycan and GAPDH (endogenous control) was assessed by qRT-PCR in C2C12 cells ...
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Accelerated Cell Death in Podospora Autophagy Mutants
... II cell death ...suppress cell death by incompatibility, indicating that autophagy does not play a causal role in this type II PCD ...in cell death has also been investigated by ...
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Gelatin layered and multi sized porous β tricalcium phosphate for tissue engineering scaffold
... The scaffold having multi-sized pores were successfully fabricated using template coating and freeze drying methods. The gelatin-coated scaffold was fabricated uni- formly by dip coating. The compressive strength of the ...
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