cell invasion and metastasis
Tamoxifen Inhibits ER-negative Breast Cancer Cell Invasion and Metastasis by Accelerating Twist1 Degradation
... downstream of tyrosine receptor kinases and ras on- coproteins [10]. Twist1 promotes EMT in part by di- rectly repressing E-cadherin and ER expression by recruiting the nucleosome remodeling and deacety- lase (NuRD) ...
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CRP2, a new invadopodia actin bundling factor critically promotes breast cancer cell invasion and metastasis
... The present study provides evidence that CRP2 is a new actin bundling factor that localizes in breast cancer cell invadopodia and plays a critical role in invadopodia- mediated ECM degradation, cell ...
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Original Article Isatin inhibits SH-SY5Y neuroblastoma cell invasion and metastasis through PTEN signaling
... neuroblastoma cell metastasis and invasion and reveal the underlying ...NB cell viability was evaluated with the cell counting kit (CCK)-8 ...NB cell invasion and ...
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Pharmacologic reversion of epigenetic silencing of the PRKD1promoter blocks breast tumor cell invasion and metastasis
... cancer cell lines (Additional file 6: Figure ...MDA-MB-231 cell viability, and this effect was independent of the PKD1 expression status (Figure ...tumor cell invasion were partially restored ...
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miR-10b suppresses cell invasion and metastasis through targeting HOXA3 regulated by FAK/YAP signaling pathway in clear-cell renal cell carcinoma
... renal cell carcinoma ...detect cell proliferation, colony formation, migration, and invasion abilities in ...inhibited cell proliferation, migration and ...suppresses cell ...
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Toca 1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis
... cancer cell invasion and metastasis ...cancer cell migration and invasion by repressing SDF-1/ CXCL12 expression ...control cell motility and in- vasion in ovarian cancer ...that ...
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JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma
... tumor invasion and metastasis abil- ity but also in the acquisition of resistance to apoptosis and stemness properties ...increased cell migration and invasiveness is induced by stimuli or cytokines ...
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Isatin Inhibits SH-SY5Y Neuroblastoma Cell Invasion and Metastasis through LSD1 Activity Inhibition
... Prior work has documented the effectiveness of isatin in preventing cancer cells proliferation and progression. Havrylyuk[33] ,for instance, reports that isatin possess remarkable antiproliferative influence on cancer. ...
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MicroRNA-940 promotes tumor cell invasion and metastasis by downregulating ZNF24 in gastric cancer
... Gastric cancer (GC) is the fourth most common cancer and second leading cause of cancer-related deaths worldwide. There are about 700,000 deaths annually [1], more than half of which occur in Asia. Surgical resection ...
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MiR-99a suppresses cell invasion and metastasis in nasopharyngeal carcinoma through targeting <em>HOXA1</em>
... HONE-1 cell lines stably overexpressing miR-99a (lenti-miR-99a) or empty vector (lenti-vector), and then constructed lung metastasis models through injecting cells into the tail veins of nude ...lung ...
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Original Article Inhibition of extracellular matrix metalloproteinase inducer expression reduces clear cell renal carcinoma cell invasion and metastasis
... The protein of cells was lysed for 30 minutes on ice in cell lysis buffer. The cell lysates’ protein concentrations were determined by the BCA method (Beyotime). The proteins were placed on gradient gels of ...
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The impact of hypoxia in pancreatic cancer invasion and metastasis
... regional invasion. Several cellular mechanisms are associated with cancer cell invasion, including epithelial-to-mesenchymal transition (EMT) and invasive migration (ability to migrate while ...
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EFEMP1 promotes ovarian cancer cell growth, invasion and metastasis via activated the AKT pathway
... EFEMP1, a kind of extracellular matrix (ECM) protein, has been suggested to correlate with the development of different types of carcinoma. However, its functions in ovarian cancer remain unclear. In our study, we ...
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Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression
... HCC cell invasion and metastasis which plays important roles in resulting in a poor prognosis rather than tumorigenesis is still ...the invasion of live cancer cells and metastasis in ...
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The role of kinesin KIF18A in the invasion and metastasis of hepatocellular carcinoma
... Cell invasion was performed using a Matrigel Invasion Chamber (Corning, USA), and cell migration was per- formed using Transwell chambers (Corning, ...
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Dysregulation and functional roles of miR-183-96-182 cluster in cancer cell proliferation, invasion and metastasis
... tumor invasion and metastasis have sometimes yielded contradictory results in different tumors, and in some cases, even within the same tumor ...5 cell lines) and Xu et al. (in 65 pairs of samples ...
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MiR-876-5p modulates head and neck squamous cell carcinoma metastasis and invasion by targeting vimentin
... that cell invasiveness was higher in the over expressed vimentin group and lower in the miR- 876 mimics group than that in the control ...HNSCC cell migratory ability, whereas ...HNSCC cell migration ...
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Regulation of ezrin tension by S-nitrosylation mediates non-small cell lung cancer invasion and metastasis
... Cancer cell invasion and migration underlie metastatic dissemination, which is one of the major problems in ...the cell collective which was termed the ‘tug-of-war model’ and leader cells undertakes ...
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Novel roles of DC-SIGNR in colon cancer cell adhesion, migration, invasion, and liver metastasis
... cancer cell invasion by increasing the expression level of ...and invasion of a human glioma cell line by up- regulating MMP9 as well, and this interaction was also related to an association ...
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Podoplanin: An Insight into its Role in Tumor Invasion and Metastasis
... 54. Sonne SB, Herlihy AS, HoeiHansen CE, Nielsen JE, Almstrup K, Skakkebaek NE, Marks A, Leffers H, RajpertDe Meyts E. Identity of M2A (D240) antigen and gp36 (Aggrus, T1A2, podoplanin) in human developing testis, ...
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