cell maturation
Abnormalities of T cell maturation and regulation in human beings with immunodeficiency disorders
... spontaneously occurring acquired agammaglobulinemia. In one of the latter individuals, there was an activated suppressor T cell population expressing Ia antigens (T+/T8+, Ia+). Another had no inducer T4+ cells. ...
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Six3 is required for ependymal cell maturation
... ependymal cell maturation and increased proliferation, as Six3 is not expressed in astrocytes or progenitors in the SVZ at the stages ...in cell death observed in this ...
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CTLA4Ig inhibits T cell–dependent B cell maturation in murine systemic lupus erythematosus
... This study was designed to add to our understanding of how CTLA4Ig affects an ongoing autoimmune response. We have engineered an adenovirus that expresses murine CTLA4Ig (Ad-CTLA4Ig). Administra- tion of a single high ...
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Cigarette smoke differentially modulates dendritic cell maturation and function in time
... dendritic cell maturation and T cell prolif- eration in thoracic lymph nodes of ...DC maturation within the lymph nodes as demonstrated by reduced cell surface expression of MHC class ...
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Osteopontin promotes dendritic cell maturation and function in response to HBV antigens
... Methods: Twenty CHB patients and 20 healthy volunteers were recruited. OPN secreted by DCs was compared. Peripheral blood mononuclear cells cultured with OPN antibody were examined to study the costimulatory molecular ...
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The ubiquitin ligase Mindbomb 1 coordinates gastrointestinal secretory cell maturation
... and maturation of the apical cytoplasmic ...neck cell proteins like spasmolytic polypeptide (also known as TFF2), which is how this lesion was named and has been traditionally ...
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Biallelic mutations in IRF8 impair human NK cell maturation and function
... both cell fate decision and func- tional control of viral ...B cell lines), as PRDM1 has been previously shown to directly bind and negative- ly regulate the IFN-γ locus in human NK cells ...NK-92 ...
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Helios is a key transcriptional regulator of outer hair cell maturation
... Both cell types are thought to arise from common progenitors, however our understanding of the factors that control IHC and OHC fate remains ...functional maturation and ...functional maturation, and ...
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Toll-Like Receptor-Independent Triggering of Dendritic Cell Maturation by Viruses
... Compelling evidence demonstrates that TLR signaling leads to DC maturation (reviewed in references 46, 72, and 87). Based on the crucial role of DCs in the generation of adaptive immune responses, it has been ...
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Molecular Basis for Ebolavirus VP35 Suppression of Human Dendritic Cell Maturation
... We also addressed the effect of VP35 on TLR agonists and obtained previously undescribed outcomes. A previous study tested the effect of a VP35 R312A mutant and a separate VP35 mutant lacking the IID on LPS-treated ...
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Dual effect of Plasmodium infected erythrocytes on dendritic cell maturation
... DC maturation is reversible, as responsiveness to TLR ligands is restored if infected erythrocytes are removed, but it is also broad, as expression of co-stimula- tory molecules is inhibited in response to all ...
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The glycoprotein-hormones activin A and inhibin A interfere with dendritic cell maturation
... the maturation of DCs and to con- comitantly induce the generation of tolerogenic DCs ...to maturation stimuli prevented up-regulation of CD86 and CD83, classical features of mature DCs ...
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AKAP9 Is Essential for Spermatogenesis and Sertoli Cell Maturation in Mice
... Surprisingly, despite its widespread expression in many tissues, including the brain and heart (Lin et al. 1998; Kurokawa et al. 2004; Chen et al. 2007; Chen and Kass 2011; Chopra and Knollmann 2011; Kendler et al. ...
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Effects of Aryl-Hydrocarbon Ligands on Dendritic Cell Maturation
... dendritic cell (BMDC) maturation and immuno-stimulatory or immuno-suppressive ...BMDC maturation had no significant effect on the expression of MHC class II, CD40 and CD86, with the exception of I3C ...
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ERYTHROID CELL MATURATION AND HEMOGLOBIN SYNTHESIS IN MEGALOBLASTIC ANEMIA
... No population of cells with increasing globin synthesis and decreasing heme synthesis, such as is noted in the primitive erythroid cells of normal subjects cells that appear in the perip[r] ...
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Modulation of dendritic cell maturation by ribotoxic and oxidative stress
... in cell viability as measured by MTT reduction (a measure of mitochondrial function) Anisomycin activated p38 in DC at concentrations as low as 1 ng/ml and gave a ...
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Increased pressure stimulates aberrant dendritic cell maturation
... Abstract: Patients with malignancy typically exhibit abnormal dendritic cell profiles. Interstitial tumor pressure is increased 20-50mmHg over that in normal tissue. We hypothesized that elevated pressure in the ...
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Endogenous laminin is required for human airway smooth muscle cell maturation
... serum-free cell culture system that pro- motes myocyte maturation ...other cell systems, the peptide inhibitors for laminin binding that we used were well suited for in vitro investigation, and thus ...
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Marrow Cell Egress THE CENTRAL INTERACTION OF BARRIER PORE SIZE AND CELL MATURATION
... To test this hypothesis, we placed human marrow cells in a chamber between millipore or nucleopore filters with pore diameters of 1-8 µm. Fixed, stained, cross sections of the filters allowed histological examination of ...
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BAFF- and APRIL-targeted therapy in systemic autoimmune diseases
... B cell-activating factor; BCMA: B cell maturation antigen; BCR: B cell receptor; BILAG: British Isles Lupus Assessment Group; BLyS: B lymphocyte stimulator; Breg: B regulatory; ESSDAI: EULAR ...
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