cellular damage
The right choice of antihypertensives protects primary human hepatocytes from ethanol- and recombinant human TGF-β<sub>1</sub>-induced cellular damage
... We measured LDH activity in culture supernatants of hHeps treated with 100 mM ethanol and/or 5 ng/mL rhTGF- β 1 in the presence or absence of antihypertensive drugs. After 72 hours both ethanol and rhTGF- β 1 induced ...
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Furfural induces reactive oxygen species accumulation and cellular damage in Saccharomyces cerevisiae
... any damage caused by the ...related cellular damage in ...cause cellular damage that is consistent with ROS accumulation in cells which includes damage to mitochondria and ...
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Meningitis Induced by Streptococcus Pneumoniae Elicits Cellular Damage but not DNA Damage during the Acute Phase of Infection in the Hippocampus of Wistar Rats
... brain damage characterized by necrotic tissue damage in the cerebral cortex and apoptosis of neurons in the hippocampal dentate ...DNA damage due to the effect of pneumococcal meningitis on the ...
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Radioprotective agents to prevent cellular damage due to ionizing radiation
... DNA damage was similar between treatment and control groups before the bone scan ...DNA damage treatment and control groups after the scan ...radiation damage in humans after a nuclear medicine scan, ...
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Protective Efficacy of Asparagus racemosus root extract and Isoprinosine against Ionizing Radiation - induced Clastogenicity and Toxicity in Swiss Albino Mice
... induce cellular damage mediated through oxidative processes, it is possible that the significant reduction in observed chromosomal damage in the ARE and IPR pre-treatment group compared to the ...
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A comparative study of DNA damage in patients suffering from diabetes and thyroid dysfunction and complications
... In addition, we have shown Pearson’s correlation coefficient (r) among apoptotic cells, FBS, and thyroid hormone levels (Table 3). There was significant correlation observed between apoptotic cells and FBS (r = 0.78; P , ...
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Algal symbionts increase oxidative damage and death in coral larvae at high temperatures
... oxidative cellular damage in larvae with zooxanthellae suggest that oxidative stress originating in the symbionts is a cause of tissue damage in the host under heat ...
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Associations between lifestyle, physical and social environments and frailty among Chinese older people: a multilevel analysis
... A large amount of evidence shows that multiple aetiologic factors, including cumulative cellular damage, malnutrition, sarcopenia, and inflammation, contribute to frailty [7]. Exercise and appropriate ...
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Aging-associated oxidized albumin promotes cellular senescence and endothelial damage
... In this study, the upregulation of ROS induced by oxidized albumin is correlated with an increase in the number of senescent cells. These data support the idea that the oxidized albumin may be considered a cardiovascular ...
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Serotype-Specific Inactivation of the Cellular DNA Damage Response during Adenovirus Infection
... the cellular DNA damage response unless as-yet unidentified mechanisms also are in- ...the cellular damage response pathways, as Ad12 (alone of the viruses examined here) degrades TOPBP1 ...
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Evaluation of Hepatoprotective and Antioxidant Effect of Solanum Seaforthianum Leaf Extract against Ccl4 - Induced Li~1
... Dept. of Pharmacology 38 J.K.K.M.M.R.F. College of Pharmacy Oxidative stress results when reactive forms of oxygen are produced faster than they can be safely neutralized by antioxidant mechanisms. (Sies,1991) and/or ...
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DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's disease
... DNA damage response The fact that cell cycle and DNA damage events are not co-localized during early stage AD suggests that these two events are temporally sequential or mutually exclu- ...DNA damage ...
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LKB1 is a DNA damage response protein that regulates cellular sensitivity to PARP inhibitors
... Analysis of the LKB1 protein sequence and structure has shown that LKB1 Thr 363/366 (Thr 363 in human, Thr 366 in mouse) lies in an optimal phosphorylation motif for ataxia telangiectasia mutated kinase (ATM), ATM- and ...
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<p>The cGAS/STING pathway: a sensor of senescence-associated DNA damage and trigger of inflammation in early age-related macular degeneration</p>
... DNA damage and genomic ...DNA damage in retina. 56 DNA damage is regarded as both an important hallmark and a key trigger of senes- ...DNA damage response (DDR) in age- ing cells leads to ...
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Physical Interaction between the Herpes Simplex Virus Type 1 Exonuclease, UL12, and the DNA Double-Strand Break-Sensing MRN Complex
... Residues in the N terminus of UL12 are responsible for the interaction with the MRN complex. In order to more finely map the region of UL12 responsible for the MRN interaction, cells were transfected with a series of ...
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Heat shock proteins and hormesis in the diagnosis and treatment of neurodegenerative diseases
... Lipid peroxidation is one of the major sources of free radical mediated injury that directly damages mem- branes and generates a number of secondary products. The overall process of lipid peroxidation consists of three ...
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Spy1 Regulation of the DNA Damage Response; Checkpoint Activation and Cellular Senescence
... DNA damage-induced breaks, repair mechanisms like non-homologous end joining (NHEJ) are able to join any two dysfunctional chromosomal ends and lead to chromosomal fusions by recombination ...DNA damage ...
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Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences
... The position of the sequences examined in each gene and primers used to amplify the sequences of interest are listed in Table 1. The basis of the assay is that treatment of DNA with formamidopyrimidine DNA glycosylase ...
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Evolution of the cellular stress proteome: from monophyletic origin to ubiquitous function
... A complicating factor in such a conceptual framework is the possibility that some species have secondarily acquired or ‘re- invented’ eury-tolerance, perhaps by recruiting a few novel genes to reconstitute the ...
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HEPATOPROTECTIVE ACTIVITY OF ELYTRARIA ACAULIS IN CCL4 INDUCED HEPATO TOXIC ALBINO RATS
... 6. Kavitha. BT, Shruthi SD, Padmalatha Rai S, Ramachandra. YL. (Phytochemical analysis and hepatoprotective properties of Tinospora cordifolia against carbon tetrachloride- induced hepatic damage in rats). Journal ...
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