chemical biology
Improving integrative searching of systems chemical biology data using semantic annotation
... of chemical compounds of biological interest based on their chemical structural and functional features ...formalize chemical biology experi- ments and provide guidance for data ...
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Chemical Biology of Resistant and Susceptible Species of Abies to Balsam Woolly Adelgid (Adelges piceae)
... alters chemical composition of multiple Abies species, and how that varies by susceptibility ranking could be useful in determining resistance ...the chemical biology of Abies, the exact nature of ...
143
A Chemical Biology Approach to Developing STAT Inhibitors: Molecular Strategies for Accelerating Clinical Translation
... inhibition, chemical biology approaches have been particularly fruitful in identifying compounds that can modulate this pathway through a variety of ...of chemical libraries can then be employed in ...
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A Chemical Biology Platform to Develop Small Molecule Probes for Bromodomains
... In this dissertation, two different types of assay platforms were developed and implemented. In Chapter 2, I discussed a chemical biology assay platform for the development of CBP bromodomain inhibitors, ...
109
Epigenetic assays for chemical biology and drug discovery
... Chemical biology makes use of chemistry to under- stand biological processes and this overlaps signifi- cantly with drug discovery, especially when the latter focusses on small molecules ...[1]. ...
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Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach
... worldwide. Chemical validation of new antimalarial targets is urgently required in view of rising resistance to current ...integrated chemical biology approach to explore protein myristoylation in ...
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On the chemical biology of the nitrite/sulfide interaction
... potential chemical biology of the interaction between nitrite and sulfide or sulfane sulfur molecules, calling attention to the fundamental chemical properties and reac- tivities of either species and ...
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Exploring chemoselective S to N acyl transfer reactions in synthesis and chemical biology
... S-to-N acyl transfer reactions in synthesis have been studied across a broad range of ring transition state (TS) sizes, from the widely utilized 5-membered rings found in NCL up to 32-membered cyclic TS 137 . It is ...
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The Microphenotron: a robotic miniaturized plant phenotyping platform with diverse applications in chemical biology
... the chemical treatment is present in the agar at the time of ...the chemical treatment can, if required, be delayed until after germination, so that effects on later developmental processes can be stud- ied ...
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R4 and R12 subfamily RGS proteins : structures, functions, and emerging chemical biology
... assay biology and the reproducibility of compound transfer, yielded concentration-response curves that remained stable and reproducible throughout the screens (Figure ...
281
Systems and chemical biology approaches to study cell function and response to toxins
... The molecular mechanism for how xenobiotics exert beneficial or detrimental effects on biological systems is important for many applications in pharmacology and biomedicine. Gene expression screens performed ...
130
Chemical biology of heparan sulfate. Development of tools, and use of sugar analogs to inhibit heparan sulfate biosynthesis and angiogenesis
... Archiving of clinical tissue samples is generally done by formalin fixation and paraffin wax embedment. Formalin-fixed, paraffin-embedded (FFPE) tissues are valuable samples, typically generated from human specimens, and ...
205
Understanding the "rules of engagement" for membrane protein folding : chemical biology and computational approaches for determination of structure and dynamics
... Two decades ago, a simple two-stage model of helical membrane protein spontaneous insertion and association was proposed (13). The first stage describes the spontaneous insertion of a hydrophobic protein into the bilayer ...
269
Target identification and validation studies in chemical biology & Synthesis of medium sized ring containing compounds via oxidative fragmentation
... In the Y2H system, direct interactions of fusion proteins are studied.122-125 In the Y3H approach Figure 1.11, the interactions between DBD- and AD- fused proteins are mediated by a thir[r] ...
246
A chemical biology approach to discover the biological targets of the antiepileptic drug lacosamide
... Lacosamide (Vimpat ® ) is a potent antiepileptic drug that received market approval for the adjunctive treatment of partial-onset seizures in adults in Europe and the United States. The pharmacological studies document ...
403
Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology.
... concerning chemical probes are usu- ally published in specialist chemical biology journals for which the readership mainly comprises experts already well aware of the issues and current best practice ...
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Biology Unit Biology B1b (Evolution and Environment)
... In graph 1 , what percentage of the people surveyed in Town 1 would buy GM foods, but would like more information about them.. 1 28 %.[r] ...
32
Stem cell biology meets systems biology
... Cell Biology and Genetics, Dresden, Germany), who presented the results of a genome-wide RNAi screen for genes that affect ES cell identity via alteration of Oct4 expression (Ding et ...
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A Place for the Nature of Biology in Biology Education
... of biology with an objective in which students, “Develop an understanding of the scientific value and limitations of using living model organisms in biological research, especially as they pertain to an ...
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BIOLOGY 3A GENERAL BIOLOGY I Spring 2016
... About this course: Biology 3A is the first in a three-course sequence designed for those majoring in the biological sciences, including pre-health professionals. The goal of this course is to introduce the student ...
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