Chemokine binding
Identification of a Gammaherpesvirus Selective Chemokine Binding Protein That Inhibits Chemokine Action
... We considered the hypothesis that herpesviruses, like pox- viruses, encode secreted chemokine binding proteins and tested this hypothesis using murine ␥HV68. ␥HV68 is a gam- ma-2 herpesvirus with homology ...
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Chemokine Binding Protein M3 of Murine Gammaherpesvirus 68 Modulates the Host Response to Infection in a Natural Host
... broad chemokine-binding properties in vitro, has no discernable effect during experimental infection via the respiratory ...on chemokine and cytokine levels within the lungs of infected wood mice ...
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SECRET domain of variola virus CrmB protein can be a member of poxviral type II chemokine binding proteins family
... Prediction of secondary structure of VARV-CrmB SECRET domain was done using PSIPRED server [10]. Spatial structure of SECRET domain was modeled using I-TASSER web-server [11]. The server selected the structure of cowpox ...
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Critical role for a high affinity chemokine binding protein in γ herpesvirus–induced lethal meningitis
... of binding to a broad spectrum of chemokines and blocks chemokine signaling (7, ...this chemokine-binding protein in herpesvirus infection, we constructed a recombinant ...
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Schistosoma mansoni secretes a chemokine binding protein with anti inflammatory activity
... The coevolution of humans and infectious agents has exerted selective pressure on the immune system to control potentially lethal infections. Correspondingly, pathogens have evolved with various strategies to modulate ...
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Structural Determinants of Chemokine Binding by an Ectromelia Virus-Encoded Decoy Receptor
... the chemokine binding pro- tein encoded by gammaherpesvirus 68, can provide insight into common features of chemokine sequestration by viruses, in addition to highlighting novel mechanisms exploited ...
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Disruption of CCL21-Induced Chemotaxis In Vitro and In Vivo by M3, a Chemokine-Binding Protein Encoded by Murine Gammaherpesvirus 68
... with chemokine function is composed of the chemokine-binding ...proteoglycan binding site conserved in many chemokines ...the chemokine-binding protein family disrupt the ...
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The viral anti inflammatory chemokine binding protein M T7 reduces intimal hyperplasia after vascular injury
... of chemokine-directed cellular migration, but may be due to either direct chemokine binding or to altered regula- tion of chemokine expression as noted ...
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Cytokines regulation of chemokine and chemokine receptor in relation to multiple sclerosis
... CCL2 binding to astrocytes was th en determ ined to evaluate any autocrine action on astrocytes in a single astro cyte ...2-independent binding of CCL2 was confirmed by th e absence of intracellular ...
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Soluble syndecan 3 binds chemokines, reduces leukocyte migration in vitro and ameliorates disease severity in models of rheumatoid arthritis
... for chemokine binding in chronic inflammatory diseases, Patterson et ...CXCL8 chemokine-binding site on this HSPG on ECs not present in healthy controls ...alter chemokine-driven ...
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Differential binding of chemokines to macrophages and neutrophils in the human inflamed synovium
... of chemokine binding sites on macrophages increases in the inflamed intima of RA and non-RA synovia suggests that these receptors may function in chronic severe synovitis in RA and more mild synovitis ...
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CCR5 signalling, but not DARC or D6 regulatory, chemokine receptors are targeted by herpesvirus U83A chemokine which delays receptor internalisation via diversion to a caveolin-linked pathway
... U83A binding competition was screened against chemok- ines also relevant for regulatory receptor ...their binding can be com- peted by U83A on signalling receptors CCR1 and CCR5 as shown in previous tests ...
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Native-mimicking in vitro microenvironment: an elusive and seductive future for tumor modeling and tissue engineering
... ous chemokine ligands in mice and humans that are im- portant to cellular and humoral immune responses and maintenance of tissue ...expressing chemokine receptor CXCR4 ...
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Stromal derived factor-1 mediates the lung regenerative effects of mesenchymal stem cells in a rodent model of bronchopulmonary dysplasia
... following binding to its re- ceptors, chemokine receptor 4 (CXCR4) or chemokine receptor 7 (CXCR7) modulates cell adhesion, migration, proliferation, survival, and differentiation ...this ...
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Identification of novel candidate indicators for assessing zinc status during pregnancy in mice from microarray data
... on the outcome of inflammatory diseases, such as in- flammatory bowel disease [42]. Moreover, maternal zinc supplementation is found to impact beneficial effects on neonatal immune status and infant morbidity from in- ...
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Chemokines activate Kaposi's sarcoma associated herpesvirus G protein coupled receptor in mammalian cells in culture
... IL-8 binding to human chemokine receptors CXCR1 and CXCR2 are important for KSHV-GPCR acti- vation ...ELR binding site and other key domains of ELR chemokine activation have been preserved in ...
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Increasing the Immunogenicity of Vaccinia Virus Vectors by Insertion of Cowpox Virus A-Type Inclusions.
... cervical cancer cell line, is a double-‐stranded RNA binding protein that is believed to act by binding and sequestering double-‐stranded RNA. K3L, required for replication in baby hamster kidney (BHK) ...
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Haplotype structure and linkage disequilibrium in chemokine and chemokine receptor genes
... of chemokine and chemokine receptor variation will be applicable to more extensive surveys of long-range haplotype structure in these gene regions and to association studies of HIV-1 disease and ...
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Dysregulation of chemokine receptor expression and function in leukocytes from ALS patients
... CC- chemokine receptor 2; CCR5: CC-chemokine receptor 5; CD11B: Cluster of differentiation 11B; CXCR3: CXC-chemokine receptor 3; CXCR4: CXC- chemokine receptor 4; INF- γ : Interferon-gamma; ...
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Influence of Fiber Detargeting on Adenovirus-Mediated Innate and Adaptive Immune Activation
... lowing a 30-minute incubation, cells were washed twice with fresh medium to remove free virus. Cells were incubated for 24 h and harvested for reporter gene assay. The Ad5 and F41T vectors were highly effective at ...
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