Chimeric antigen
Car Drivers and Fuel Sources: How Distinct Signaling Domains in Chimeric Antigen Receptors Reprogram T Cells
... With breakthroughs in synthetic biology, improved cell culture techniques and advanced genetic engineering, it has now become possible to generate bi-specific primary human T cells with desired specificities. One mode of ...
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Alloantigen specific regulatory T cells generated with a chimeric antigen receptor
... allogeneic antigen-presenting cells, which requires access to donor and recipient cells and multiple MHC ...of chimeric antigen receptors (CARs) for the generation of antigen-specific effector ...
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A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer
... same chimeric antigen receptor recognizing the same tumor ...the chimeric antigen ...The chimeric antigen receptor used in our studies is comprised of T cell intracellular ...
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CHIMERIC ANTIGEN RECEPTOR FOR CHRONIC LYMPHOCYTIC LEUKEMIA A REVIEW
... immunotherapy chimeric antigen receptor (CAR) is ...the antigen of the tumor cells and not damage the normal cells in the ...the antigen present on the surface of the tumor cells, they will ...
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Chimeric antigen receptor T cell therapies for multiple myeloma
... mature antigen; BsAb: Bispecific antibody; CARs: Chimeric antigen receptors; CAR-T: Chimeric antigen receptor-modified T cells; CD: Cluster of differentiation; CLL: Chronic lymphocytic ...
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T Cells Bearing a Chimeric Antigen Receptor Against the Tumor Vasculature Destroy the Tumor Endothelium and Result in Tumor Regression
... two chimeric antigen receptors (CAR)s against the tumor vasculature, targeting either tumor endothelial marker 1 (TEM1) or prostate-specific membrane antigen ...
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Designed ankyrin repeat proteins are effective targeting elements for chimeric antigen receptors
... a chimeric antigen receptor which uses a DARPin for its antigen recognition domain, we exchanged the scFv domain of a second generation CAR with specifi- city against HER2 [20] (herein referred to as ...
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Chimeric antigen receptor T cells: a novel therapy for solid tumors
... hibited higher expansion, cytokine secretion, and cyto- toxicity when exposed to HER2-expressing cells [73]. To reduce antigen escape, Hegdeet et al. created a bispecific CAR molecule co-targeting the two ...
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Chimeric antigen receptors: unleashing a new age of anti-cancer therapy
... Novel developments and current clinical trials To circumvent the challenges and present limita- tions of CAR T cell monotherapy, scientists have sug- gested the use of combinational therapies to enhance CAR efficacy. For ...
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Chimeric antigen receptor T cell therapy for multiple myeloma
... cancer-specific antigen epitopes formed by post-translational events, such as glycosylation, complex formation, or conformational changes, might have been missed in previous ...Such antigen epitopes could ...
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T cells expressing chimeric antigen receptor promote immune tolerance
... immune cell types, to govern physiological immune responses. Tregs have been engineered to express CARs, with the aim of suppressing antigen-specific immune responses in different diseases (10, 11). The use of ...
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Elutriated lymphocytes for manufacturing chimeric antigen receptor T cells
... GD2-CAR T cells were manufactured over 10 or 11 days using autologous PBMC concentrates enriched for lymphocytes using one of 3 methods: anti-CD3/CD28 bead selection n = 6, circles, anti[r] ...
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Design, Construction, and Evaluation of a Specific Chimeric Antigen To Diagnose Chagasic Infection
... Chagas’ disease is routinely diagnosed by detecting specific antibodies (Abs) using serological methods. The methodology has the drawback of potential cross-reactions with Abs raised during other infectious and ...
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Multicomponent Chimeric Antigen for Serodiagnosis of Canine Visceral Leishmaniasis
... Although those antigens belong to evolutionarily conserved protein families, it was observed that the humoral response elicited in dogs with VL is specifically directed against the parasite proteins. However, given the ...
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Multi-antigen-targeted chimeric antigen receptor T cells for cancer therapy
... cognate antigen (CD19-targeted scFv-CD28/CD3 ζ ); however, another CAR specific for prostate-specific membrane antigen (PSMA) consisted of an inhibitory signaling domain derived from PD-1 or CTLA-4 instead ...
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Cancer biomarkers for targeted therapy
... Tumor-associated antigens (TAA) or cancer biomarkers are major targets for cancer therapies. Antibody- based agents targeting the cancer biomarkers include monoclonal antibodies (MoAbs), radiolabeled MoAbs, bispecific T ...
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Development and Evaluation of a Novel ELISA for Detection of Antibodies against HTLV-I Using Chimeric Peptides
... in chimeric antigen ...of chimeric peptide ELISA with pooled positive ...with chimeric peptides described previously indicated that the CP-1 yielded a higher OD450nm ...
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Abstract: Despite advances in the understanding of its molecular pathophysiology, prostate cancer
... a chimeric antigen receptor (CAR) specific for prostate specific membrane antigen (PSMA), a glycoprotein that is overexpressed in prostate cancer, which expression involves neovasculature of several ...
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Emerging trends in immunotherapy for pediatric sarcomas
... and chimeric antigen receptors (CAR); both approaches utilize cells engineered to express recep- tors with known tumor antigen ...class-II antigen presentation drives CD4+ helper T cell ...
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Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy
... APCs: Antigen-presenting cells; B7-H1: B7-homolog 1; BTLA: B and T lymphocyte attenuator; CAR: Chimeric antigen receptor; CD137: 4-1BB; CLL: Chronic lymphocytic leukemia; CTL: Cytotoxic T lymphocyte; ...
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