Chimeric antigen receptor T-cells
Mesothelin is a target of chimeric antigen receptor T cells for treating gastric cancer
... CAR T cells have achieved re- markable success in acute lymphoblastic ...CAR T cells to treat solid cancer [33, ...CAR T cells M28z10 compared with the second-generation M28z CAR ...
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Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses
... functional T cell infiltration is associated with sustained tumor regression after mesothelin-redirected chimeric antigen receptor T cells (meso-CAR T cells) and ...
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Co-infusion of haplo-identical CD19-chimeric antigen receptor T cells and stem cells achieved full donor engraftment in refractory acute lymphoblastic leukemia
... Another major concern is the safety of allogeneic CAR-T cells, particularly for severe GVHD. In this study, the patient developed obvious liver dysfunction and skin rash associated with donor cell ...
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Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells
... 5 cells, and the A549-GL carcinoma lines were inoculated into 5 × 10 5 cells subcutaneously ...CAR T cells intravenously 3–14 days later, as indicated in the indi- vidual ...non-transduced ...
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MAGE-A1 in lung adenocarcinoma as a promising target of chimeric antigen receptor T cells
... tumor antigen that is physiologically expressed in the germ cells of the testes as well as in a variety of malignant tumors but not in normal tissues ...
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Elutriated lymphocytes for manufacturing chimeric antigen receptor T cells
... When the PBMC concentrates were enriched for lym- phocytes by elutriation they were subject to elutriation using a semi-automatic counter-flow elutriation instru- ment (Elutra Cell Separation System, version 1.1, Terumo ...
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Multi-antigen-targeted chimeric antigen receptor T cells for cancer therapy
... CAR-T cells is being tested as a strat- egy to reduce relapse ...CAR-T cells: mixtures of two engi- neered T cell lines, each of which expresses a distinct antigen-specific CAR; ...
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Chimeric antigen receptor T cells: a novel therapy for solid tumors
... transmembrane receptor tyrosine kinase belonging to the ErbB (also known as HER) onco- gene family ...and receptor activation by occupying the ligand-binding site of the ...ideal antigen for ...
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Hong_unc_0153D_17522.pdf
... cancer cells has a more than 100-year history, beginning in 1891 when William Coley, upon observing that cancer patients with infections showed better tumor control, used a mixture of heat-killed bacteria to ...
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Car Drivers and Fuel Sources: How Distinct Signaling Domains in Chimeric Antigen Receptors Reprogram T Cells
... tumor-specific T cells have reported recurrence or outgrowth of tumor ...cytolytic T cells persisted longer, they would have a higher chance of mediating durable tumor ...of T cell ...
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Chimeric antigen receptor T cell therapy for multiple myeloma
... CAR T cells against acute lymphocytic leukemia and malignant lymphoma, very high complete remission rates were reported ...CAR T cell therapy has been approved by the FDA in the USA in ...anti-IL6 ...
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Chimeric antigen receptor T cell therapies for multiple myeloma
... CAR-T cells in the peripheral blood at 4 months, and only 5 patients showed CAR-T cells at 10 months after infusion ...abnormalities t(4,14) and del(17p) were reported in 6 pa- tients ...
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Rejection of Experimental Hodgkins Lymphoma by T Cells Engineered with a CD19 Chimeric Antigen Receptor
... 6% cells expressing CD34 as a marker of ...transduced cells in the total population by CD34 selec- tion improved levels of specific lysis (Figure ...CD34+ cells and level of specific ...of T ...
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Expression of miR-17-92 enhances anti-tumor activity of T-cells transduced with the anti-EGFRvIII chimeric antigen receptor in mice bearing human GBM xenografts
... 4 T-cells were co- cultured with 2 × 10 4 γ -irradiated aAPC in each well of 96-well plates and treated with graded concentrations of TMZ (Sigma-Aldrich, ...of T-cell proliferation was per- formed by ...
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Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy
... CAR T cell ...CAR T cells in vitro but, interestingly, did not appear to modulate cytotoxic function of CAR T ...OT-I T cells cocultured with OVA-expressing tumor cells ...
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CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients
... T cells and thus their clinical benefits (8, 20, ...by T cells to allow them to pass through the physiological sequence of activation, proliferation, and survival check points to which ...
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The potential of CAR T therapy for relapsed or refractory pediatric and young adult B-cell ALL
... as chimeric antigen receptor (CAR) T cells, which have revolutionized the treat- ment of pediatric patients with relapsed or refractory B-cell acute lymphoblastic ...CAR ...
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Metabolic communication in tumors: a new layer of immunoregulation for immune evasion
... tumor antigen-specific T cells due to clonal deletion; 2) poor activation of innate immune cells and accumulation of tolerigenic antigen-presenting cells in the tumor ...
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Chimeric antigen receptor-modified T cell therapy in chronic lymphocytic leukemia
... CAR-T cells in blood is positively associated with efficacy and toxicity in ...CAR-T cells approximately reach to 100/μl and 30/μl, respectively, the estimated probability of marrow ...
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Construction and evaluation of a novel humanized HER2 specific chimeric receptor
... human T cells expressing chA21 scFv-28z-based CARs lysed HER2+ breast and ovarian cancer cells with high ...CAR T cells recognized and killed tumor cells in an MHC-independent ...
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