cholera toxin A-subunit
Genetic Determinants Differences between Vibrio cholerae Biotypes
... RtxA toxin resembles other RTX toxin family and contains a GD-rich repeated motif in its ...current cholera pandemic, possess a functional gene cluster and demonstrate cytotoxic activity ...(36). ...
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Designing, Optimization and Construction of Myelin Basic Protein Coding Sequence Binding to the Immunogenic Subunit of Cholera Toxin
... Background and Objectives: Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease. Mucosal feeding of myelin basic protein binding to the cholera toxin B subunit can reduce the ...
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A Cholera Toxin B-subunit Variant That Binds Ganglioside G M1 but Fails to Induce Toxicity
... high toxin concentrations, a fraction of CT-H57A clearly entered the cell by binding cell- surface receptors and moved retrograde into the ER as evi- denced by the induction of a Cl ⫺ secretory response, these ...
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Kinetics of Local and Systemic Immune Responses after Vaginal Immunization with Recombinant Cholera Toxin B Subunit in Humans
... recombinant cholera toxin B subunit (CTB) in generating mucosal and systemic immune responses in healthy women were evaluated, and the kinetics of the immune responses were monitored for responding ...
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Cell propagation of Cholera Toxin CTA ADP-ribosylating factor by exosome mediated transfer.
... Results show that as early as 1 h cells secrete a discrete population of F-exo that can be FACS counted. Equal numbers (3x10 7 ) of F-exo collected at 1 h and 24 h (subtracted of the 1 h time point sample) were run on ...
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Comparison of Serum Humoral Responses Induced by Oral Immunization with the Hepatitis B Virus Core Antigen and the Cholera Toxin B Subunit
... tion, can induce a serum humoral response of a potentially protective level. Because the C-terminal arginine-rich region might contribute to the immunogenicity of the VLP, the full- length protein was used. ...
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Influence of Exogenous Reproductive Hormones on Specific Antibody Production in Genital Secretions after Vaginal Vaccination with Recombinant Cholera Toxin B Subunit in Humans
... weekly vaginal vaccinations (16). The progesterone level is low on day 10 and high on day 24 of the cycle, whereas the estrogen level is high at both time points. Kozlowski et al. (19) did evaluate the outcome of monthly ...
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Cholera Toxin B-Subunit Gene Enhances Mucosal Immunoglobulin A, Th1-Type, and CD8+ Cytotoxic Responses When Coadministered Intradermally with a DNA Vaccine
... CtB subunit alone during both priming and booster intradermal immunizations strongly en- hances the immune responses mediated by a DNA ...powerful toxin in hu- mans, the CtB subunit is considered ...
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Compound DNA vaccine encoding SAG1/ SAG3 with A2/B subunit of cholera toxin as a genetic adjuvant protects BALB/c mice against Toxoplasma gondii
... doi:10.1186/1756-3305-6-63 Cite this article as: Cong et al.: Compound DNA vaccine encoding SAG1/ SAG3 with A2/B subunit of cholera toxin as a genetic adjuvant protects BALB/c mice again[r] ...
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Gas phase characterization of the noncovalent quaternary structure of Cholera toxin and the Cholera toxin B subunit pentamer
... of cholera each year ...A subunit ( ; ...the toxin, whereas the A2-domain assists in the tethering of the A1-domian to the B subunit pentamer by inserting noncovalently into and through the ...
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Tetra- versus Pentavalent Inhibitors of Cholera Toxin
... ing mode, involving two toxins, was not as expected, as the two ligands per arm engaged two separate toxins rather than two binding sites per toxin subunit. However, so far, no experi- ments were undertaken ...
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Neutralization of cholera toxin by Rosaceae family plant extracts
... pentameric subunit B that binds to gangliosides located on human cell surfaces ...the toxin binds to gangliosides and is then in- ternalized from the plasma membrane by endocytosis and undergoes retrograde ...
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Recombinant toxin-coregulated pilus A (TcpA) as a candidate subunit cholera vaccine.
... IV toxin-coregulated pilus ...into toxin-coregulated pilus (Tcp), a type IVb pilus. The toxin co-regulated pilus (TCP) that is required for colonization of ...a cholera subunit vaccine ...
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A protein-based pentavalent inhibitor of the cholera toxin B-subunit.
... including cholera toxin (CT), enter the cell by first binding to glycolipids in the cell ...the toxin from entering cells and causing ...target toxin, provides a convenient route to an ...
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Anti-inflammatory effect of cholera toxin B subunit in experimental stroke
... Cholera toxin is composed of one A subunit and five B ...The cholera toxin B subunit (CTB) is devoid of toxicity and capable of ...
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DNA homology and immunological cross reactivity between Aeromonas hydrophila cytotonic toxin and cholera toxin
... Concentrated 10x céll-free supernatants or lysates from eight cultures, heated at 56°C for 20 min, produced cytotonic effects in Y-1 mouse adrenal cells and Chinese hamster ovary CHO cel[r] ...
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In vitro and in vivo cholera toxin production by classical and El Tor isolates of Vibrio cholerae
... A comparative study was carried out on the in vitro production of cholera toxin by 19 Vibrio cholerae El Tor isolates from patients with cholera in South Africa, one El Tor isolate from [r] ...
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Lipid Membrane Based Biosensors
... Graphene nanomaterials have received tremendous interest in the field of basic research and in technological applications due to their unique physicochemical properties, i.e., good sensing ability, and excellent ...
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Effects of cholera toxin on adenylate cyclase Studies with guanylylimidodiphosphate
... of cholera toxin and Gpp(NH)p on adenylate cyclase was ...by cholera toxin in vivo, or by cholera toxin and NAD in homogenates, blocked the stimulatory effect of ...
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DIARRHOEAL DISEASES
... Enteropathogenic E.coli (EPEC) strains do not produce either heat stable or heat labile toxin, they do not invade the gut but still cause diarrhoea which might be due to some different type of toxin. They ...
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