Choline kinase
Computer Aided Drug Design Strategies to Model Choline Kinase, Phosphodiesterases and Phospholipase Inhibitors
... relationship studies on a series of bis-pyridinium compounds as choline kinase inhibitors. QSAR & Comb. 3) Janardhan S, Srivani P and Sastry GN., Choline kinase: An important targe[r] ...
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Global metabolic profile identifies choline kinase alpha as a key regulator of glutathione-dependent antioxidant cell defense in ovarian carcinoma
... include: choline kinase (ChoK), which produces PCho, and PtdCho-specific phospholipase C which, by degrading PtdCho, contributes to restore the PCho pool [20, ...21]. Choline kinase alpha ...
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Plasmodium falciparum choline kinase inhibition leads to a major decrease in phosphatidylethanolamine causing parasite death
... falciparum choline kinase inhibitors both in vitro and in ...the choline/ethanolamine-binding site of P. falciparum choline kinase, reflecting different types of ...ethanolamine ...
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Original Article The downregulation of choline kinase alpha inhibits clear cell renal cell carcinoma proliferation and metastasis via the MAPK and PI3K/AKT pathways
... Abstract: The abnormal expression of choline kinase alpha (CHKA) is associated with the development and pro- gression of a variety of human malignancies. This study found that in patients with clear cell ...
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Human Choline Kinase-α Promotes Hepatitis C Virus RNA Replication through Modulation of Membranous Viral Replication Complex Formation
... Hepatitis C virus (HCV) infection reorganizes cellular membranes to create an active viral replication site named the membra- nous web (MW). The role that human choline kinase-␣ (hCK␣) plays in HCV ...
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The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth
... biosynthesis. Choline kinase activity is stimulated by growth factors, like epidermal growth factor (EGF) and platelet-derived growth factor (PDGF), as well as oncogenes including Ras, Raf, Mos and c-Src ...
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Hepatitis C Virus Subverts Human Choline Kinase-α To Bridge Phosphatidylinositol-4-Kinase IIIα (PI4KIIIα) and NS5A and Upregulates PI4KIIIα Activation, Thereby Promoting the Translocation of the Ternary Complex to the Endoplasmic Reticulum for Viral Replication
... human choline kinase- ␣ (hCK ␣ ) interacts with nonstructural protein 5A (NS5A) and phosphatidylinositol-4-kinase III ␣ (PI4KIII ␣ ), the lipid kinase crucial for maintaining the integrity of ...
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Near Infrared Fluorescent Choline Kinase Inhibitors for Cancer Imaging and Therapy
... the choline-mimetic 11 C and 18 F-labeled tracers cannot distinguish choline transporter inhibition from choline phosphorylation inhibition (Zheng et ...because choline transport inhibition ...
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Reciprocal regulation of the cholinic phenotype and epithelial- mesenchymal transition in glioblastoma cells
... of choline kinase alpha reduces the cellular viability, invasiveness and clonogenicity Next we investigated if CHKα suppression is able to reduce the mesenchymal phenotype of GBM ...
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CHKA and PCYT1Agene polymorphisms, choline intake and spina bifida risk in a California population
... enzyme choline kinase (CHK; ATP:choline phosphotransferase, EC ...phosphorylates choline by donating an ATP ...uses choline phosphotransferase (CPT), which catalyzes the condensa- tion ...
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Three dimensional Proton MR Spectroscopic Imaging of Premature and Term Neonates
... Significant differences in MR spectroscopic im- aging data were also detected between anatomic re- gions within the premature and term groups (Tables 1–3). For the term infants, relative N-acetylaspar- tate and relative ...
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<p>Formulation and bioequivalence studies of choline alfoscerate tablet comparing with soft gelatin capsule in healthy male volunteers</p>
... reference choline alfoscerate (400 mg × three doses) ...of choline and 12 hours after dosing to obtain drug absorption ...of choline by using ...
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PubMedCentral-PMC4862743.pdf
... the choline utilization gene cluster identified in Desulfovibrio desulfuricans (Cracium and Balskus, 2012), several human gut microbiota reference species associated with TMA production, encoding the CutC/CutD, ...
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Citicoline affects serum angiostatin and neurospecific protein levels in patients with atrial fibrillation and ischemic stroke
... Ischemic stroke is considered as one of the most frequent and severe complications of atrial fibril- lation. The present study was undertaken to examine whether post-insult treatment with cytidine diphos- ...
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Considering choline as methionine precursor, lipoproteins transporter, hepatic promoter and antioxidant agent in dairy cows
... 2004). Choline also works as an antioxi- dant in transition cows, it has antioxidant properties that protect cell and reduce the free radical production which damage liver cells (Elsawy et ...
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Evidence for Negative Selection at SNPs Increasing Dietary Choline Requirement in a Gambian Cohort
... Numerous statistical methods have been developed for identifying genomic regions undergoing selection (see Ref. 49 for a review). Several rely on capturing multiple variants within each locus (50–52) or require densely ...
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Asthma in the elderly: the effect of choline supplementation
... by choline supplementa- ...of choline may have a different ...by choline chloride supplementation for 6 months ...of choline than utilized in our ...of choline may affect clinical ...
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Évolution de la composante lipidique de la membrane plasmique des spermatozoïdes durant la maturation épididymaire
... Chez le bélier, la proportion relative de la PC augmente de 42 à 63 % entre la tête et la queue de l ’ épididyme, au détriment de la PE, de la PS et du PI. Ainsi, chez cette espèce, le rapport PE/PC est divisé par trois ...
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Regulation of the mitogen activated protein kinase p44 ERK activity during anoxia/recovery in rainbow trout hypodermal fibroblasts
... MAP kinase kinase kinase (MAP3K) upstream of a MAPK kinase kinase (MAP2K), which in turn activates the MAP kinase (Kyriakis and Avruch, ...MAPK/ERK kinase (MEK)1/2 ...
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Maternal choline concentrations during pregnancy and choline related genetic variants as risk factors for neural tube defects
... The phosphatidylethanolamine-N-methyltransferase (PEMT) gene encodes the only enzyme known to produce choline de novo in mammals by the triple methylation of phosphatidylethanolamine to produce ...
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