Chromosome instability
Development of a novel HAC-based “gain of signal” quantitative assay for measuring chromosome instability (CIN) in cancer cells
... that chromosome instability (CIN) common to cancer cells can be used as a target for cancer ...of chromosome mis-segregation is quantified by laborious techniques such as coupling clonal cell ...
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Phenotype-Based Identification of Mouse Chromosome Instability Mutants
... isolated can be characterized later as to sensitivity to To our knowledge, this is the first successful pheno- radiation or other agents. Moreover, micronuclei can type-driven screen for chromosome ...
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HPV16 integration probably contributes to cervical oncogenesis through interrupting tumor suppressor genes and inducing chromosome instability
... Intriguingly, we also observed the enrichment of im- mune related genes (GO: 0071346 cellular response to interferon-gamma and GO:0034341 response to interferon-gamma) around HPV16 integrating sites. Interferon-gamma has ...
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Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes
... The mitotic spindle assembly checkpoint (SAC) is an essential control system of the cell cycle that contributes to mantain the genomic stability of eukaryotic cells. SAC genes expression is often deregulated in cancer ...
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A four gene signature of chromosome instability (CIN4) predicts for benefit from taxanes in the NCIC-CTG MA21 clinical trial
... Taxanes and anthracyclines are widely used for the treatment of breast cancer yet highly toxic to patients [1–4]. At present there is no biological marker or assay available to identify which subset of patients will ...
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Relative telomere lengths in tumor and normal mucosa are related to disease progression and chromosome instability profiles in colorectal cancer
... CIN, chromosome instability; CRC, colorectal cancer; cRTL, carcinoma relative telomere length; CTC1, CTS telomere maintenance complex component 1; CXCR4, chemokine (C-X-C motif) receptor 4; DFS, ...
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Hepatitis B virus PreS2-mutant large surface antigen activates store-operated calcium entry and promotes chromosome instability
... division, chromosome aneuploidy, anchorage-independent growth, and xenograft tumorigenesis in hepatocytes expressing preS2- ...and chromosome instability in hepatocytes carrying ...
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GSK-3 inhibitors induce chromosome instability
... promotes chromosome biori- entation, ...exhibit chromosome instability and are therefore karyotypically unstable and aneuploid ...the chromosome instabil- ity and recently, adenomatous ...
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Mitotic Slippage Process Concealed Cancer Sought Chromosome Instability Mechanism (S CIN)
... The conclusion is that cancer development can indeed be a complex process. Herein, old and current cancer-related observations have been brought into cancer “thinking and doing”, and where current “official” research is ...
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A CYTOLOGICAL STUDY OF wvc CHROMOSOME INSTABILITY IN CLEAVAGE MITOSES OF DROSOPHILA MELANOGASTER
... Mitotic abnormalities were scored and included pycnosis, chromosome fragmentation, increased amounts of chromatin and ana- phase bridges; the abnormalities were more frequen[r] ...
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NUMERICAL CHROMOSOME INSTABILITY IN NICOTIANA HYBRIDS. I. INTERPLANT VARIATION AMONG OFFSPRING OF AMPHIPLOIDS
... Variation among progeny plants: The somatic chromosome numbers of penta- ploid progenies ranged from 56 to 64 with a mode at the expected number of 60 (Table 2).. Since the mic[r] ...
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The Roles of Klenow Processing and Flap Processing Activities of DNA Polymerase I in Chromosome Instability in Escherichia coli K12 Strains
... deletion (dinB-yafN) allele that inactivates downstream yafO and yafP (Courcelle et al. 2001) was used. Thus, the evidence for PolIV is ambiguous (McKenzie et al. 2001). And thus, whether PolIII alone is involved in ...
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Breast primary epithelial cells that escape p16 dependent stasis enter a telomere driven crisis state
... probably reflects the low stress conditions in which BPECs are grown, lack of p16 protein at mid and late PDs (post-stasis) most probably results from inactivation of the gene encoding this tumor suppressor protein. ...
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Senescence Mutants of Saccharomyces cerevisiae With a Defect in Telomere Replication Identify Three Additional EST Genes
... quency of chromosome loss (data not shown); the ap- pearance of this increased chromosome instability was delayed, similar to the delay previously exhibited by estl-A [r] ...
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Characterization of a murine hypomorphic allele of the spindle checkpoint gene Bub1 and its role in tumorigenesis
... lethality and haploinsufficiency is compatible with viability, strong reduction of BubR1 via a hypomorphic allele causes intermediate phenotypes. The BubR1 hy/null animals die perinatally, while BubR1 hy/hy animals ...
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Pathway-based classification of genetic diseases
... to chromosome rearrangements or vice versa [7, 13, ...chromosomal/genomic instability, which is the underlying cause of the clinical outcome [17, ...Genome/chromosome instability syndromes ...
5
Viral integration drives multifocal HCC during the occult HBV infection
... CIN: Chromosome instability; CNV: Copy number variation; CSMD: CUB and sushi multiple domain; EXT1: Exostosin 1; HBeAg: HBV e antigen; HBsAg: HBV surface antigen; HBV: Hepatitis B virus; HCC: Hepatocellular ...
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Dosage Mutator Genes in Saccharomyces cerevisiae: A Novel Mutator Mode-of-Action of the Mph1 DNA Helicase
... genome instability are considered important predisposing events that contribute to initiation and progression of ...Genome instability arises either due to defects in genes that cause an increased mutation ...
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Extraordinary Genome Instability and Widespread Chromosome Rearrangements During Vegetative Growth
... dispensable chromosome during subculturing has been de- scribed for one isolate (Johnson et ...dispensable chromosome after meiosis has been observed in ...the chromosome-loss rate that we observe in ...
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Slender-Body Hypervelocity Boundary-Layer Instability
... and skin friction are several times higher when the boundary layer has transitioned from laminar to turbulent. The primary design implications are that the thermal pro- tection system must be more massive and the drag is ...
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