class I major histocompatibility complex
Human Herpesvirus 7 U21 Tetramerizes To Associate with Class I Major Histocompatibility Complex Molecules
... reroutes class I MHC molecules to lysosomes, but neither the requirements for binding of U21 to class I MHC molecules nor the mechanism of U21-mediated lys- osomal trafficking are well ...
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Human Cytomegalovirus Disrupts the Major Histocompatibility Complex Class I Peptide-Loading Complex and Inhibits Tapasin Gene Transcription
... MHC I at 8 h post infection, whereas the tapasin transcripts were downregulated at this time point, im- plying different regulatory mechanisms of their respective pro- ...
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Major histocompatibility complex class I antigens and the control of viral infections by natural killer cells.
... alter class I expression, and selective down- regulation in class I expression has been shown with adenovi- ruses (AdV), Epstein-Barr virus, HSV-1 and HSV-2, HCMV, MCMV, human immunodeficiency ...
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Japanese Encephalitis Virus Utilizes the Canonical Pathway To Activate NF-κB but It Utilizes the Type I Interferon Pathway To Induce Major Histocompatibility Complex Class I Expression in Mouse Embryonic Fibroblasts
... were provided by Inder Verma (Salk Institute of Biological Science, La Jolla, CA); NEMO ⫺/⫺ MEFs were provided by Marc Schmidt Supprian (Harvard Medical School, Boston, MA). Reconstituted MEFs and p50 ⫺/⫺ RelA ⫺/⫺ cRel ...
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Murine cytomegalovirus interacts with major histocompatibility complex class I molecules to establish cellular infection.
... 4182-4189 0022-538X/93/074182-08$02.00/0 Copyright X 1993, American Society for Microbiology JOURNAL OF VIROLOGY, Murine Cytomegalovirus Interacts with Major Histocompatibility Complex C[r] ...
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Recovery from Friend disease in mice with reduced major histocompatibility complex class I expression.
... We investigated the effects of reduced H-2D& expression on recovery from Friend disease by using H-2b homozygous mice carrying a single P2-microglobulin gene disruption.. These mice had [r] ...
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High Viremia Is Associated with High Levels of In Vivo Major Histocompatibility Complex Class I Downregulation in Rhesus Macaques Infected with Simian Immunodeficiency Virus SIVmac239
... Ex vivo detection of SIVmac239-infected cells. Since wild- type nef sequences were preserved in several rapid progressors, we hypothesized that virus in these animals might downregu- late MHC-I to a greater extent ...
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Macrophages Escape Inhibition of Major Histocompatibility Complex Class I-Dependent Antigen Presentation by Cytomegalovirus
... MHC I-dependent antigen presentation reconciles the paradox of efficient induction of CMV-specific CD8 ⴙ CTL in vivo despite extensive potential of CMVs to subvert ...
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The Major Histocompatibility Complex Class I Genes of Zebrafish.
... MHC class I protein from the cell membrane but weak enough as to maintain any interactions with ...β2M. I have employed NP-40 and Triton-X based lysis buffers and different protocols with varying ...
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Respiratory Syncytial Virus Infection Upregulates NLRC5 and Major Histocompatibility Complex Class I Expression through RIG-I Induction in Airway Epithelial Cells
... lates major histocompatibility complex class I (MHC-I) expres- sion (21–23), although many viruses have the ability to downregu- late MHC-I expression as a strategy for ...
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T-Cell Vaccination Alters the Course of Murine Herpesvirus 68 Infection and the Establishment of Viral Latency in Mice
... a major health concern, and there is significant interest in developing vaccines against this class of viral ...for class I- and class II-restricted epitopes on the acute phase of the ...
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A Noncanonical mu-1A-Binding Motif in the N Terminus of HIV-1 Nef Determines Its Ability To Downregulate Major Histocompatibility Complex Class I in T Lymphocytes
... 3. Previous reports have shown that the basic cluster supports plasma membrane binding of the myristoylated protein, includ- ing Src, MARCKS, and HIV-1 Gag, by contributing electrostatic interactions with negatively ...
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Definition of Five New Simian Immunodeficiency Virus Cytotoxic T-Lymphocyte Epitopes and Their Restricting Major Histocompatibility Complex Class I Molecules: Evidence for an Influence on Disease Progression
... MHC class I molecules that restrict virus- specific CTL responses in SIV- or simian/human immunode- ficiency virus-infected rhesus macaques have been identified (1, 2, 14, 16, 30, 44, ...MHC class ...
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Selective Downregulation of Rhesus Macaque and Sooty Mangabey Major Histocompatibility Complex Class I Molecules by Nef Alleles of Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 2
... MHC class I ...MHC class I molecules were aligned to the cytoplasmic domain sequence of ...MHC class I tail sequences indicated in bold type were selected for analysis of ...
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Viral Proteins Interfering with Antigen Presentation Target the Major Histocompatibility Complex Class I Peptide-Loading Complex
... peptide-loading complex (17, 41, 60, ...peptide-loading complex is the heterodimeric TAP composed of the TAP1 and TAP2 subunits, both containing an N-terminal transmembrane do- main and a C-terminal ...
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Differential expression of major histocompatibility complex class I in developmental glioneuronal lesions
... In FCD IIa and IIb, consistent MHC-I expression was also observed in neurons and glial cells with the morph- ology of microglial cells (Figure 3D,E,F,G and Figure 1A, B). Double labeling confirmed MHC-I ...
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Diverse Peptide Presentation of Rhesus Macaque Major Histocompatibility Complex Class I Mamu-A*02 Revealed by Two Peptide Complex Structures and Insights into Immune Escape of Simian Immunodeficiency Virus
... Studies of CTL responses of structurally defined epitopes demonstrate that a rigid peptide conformation leads to a spe- cific T-cell repertoire with limited diversity. In contrast, a di- verse TCR repertoire is evoked by ...
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Human cytomegalovirus US2 destabilizes major histocompatibility complex class I heavy chains.
... MHC class I heavy ...MHC class I heavy chain expression at both early and late times postinfection ...on class I heavy chain expression ...
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A major histocompatibility complex class I related Fc receptor for IgG on rat hepatocytes
... a major histocompatibility complex (MHC) class I-like Fc receptor, or FcRn, which transports IgG in an apical to basolateral ...MHC class I transcripts, FcRn DNA was ...
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Evolutionary Relationships of Major Histocompatibility Complex Class I Genes in Simian Primates
... likely, but uncertain. Subsequently, proto-B and -G genes expanded to generate five group B and five group G genes, respectively, and there were at least eight gene duplications during phase I. On the other hand, ...
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