Claudin Low Breast Cancer
Induction of HOXA9 expression in three-dimensional organotypic culture of the Claudin-low breast cancer cells
... Luminal breast cancer cells via miR-18’s targeting of HOXA9 ...the Claudin-low cells is consistent with this report because lrECM is much less stiff than the plastic substratum in conventional ...
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Significance of glioma associated oncogene homolog 1 (GLI1)expression in claudin low breast cancer and crosstalk with the nuclear factor kappa light chain enhancer of activated B cells (NFκB) pathway
... and claudin-low ...and claudin-low cells (Figure 7A and Figure S5 in Additional file 1) without stimulation, indicating that NFκB is present in an activated form in the ...in ...
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Treg depletion potentiates checkpoint inhibition in claudin low breast cancer
... Breast cancer is the leading cancer diagnosis and second-lead- ing cause of cancer death for women in the United States ...triple-negative breast cancers, the sur- vival benefit from ...
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Inhibition of proliferation and migration of luminal and claudin-low breast cancer cells by PDGFR inhibitors
... of breast cancer have been disappointing thus far [41-43] a recent study from the Weinberg lab reinforces the im- portance of PDGFR signaling in breast ...of breast cancer stem cells ...
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<p>Targeting PIK3CG in Combination with Paclitaxel as a Potential Therapeutic Regimen in Claudin-Low Breast Cancer</p>
... Paclitaxel (PTX) was commonly used as one of the fi rst- line chemotherapy drugs that acts as microtubule-stabilizing agent, inhibiting cancer cell mitosis in TNBC. 9,10 However, the drug resistance of PTX develops ...
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Targeted Pten deletion plus p53 R270H mutation in mouse mammary epithelium induces aggressive claudin low and basal like breast cancer
... and claudin-low like TNBC, ...human claudin-low breast cancer [9]. Claudin-low-like TNBC were also found when Pten and p53, or Rb plus p53 were homozygously deleted ...
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Claudin low like mouse mammary tumors show distinct transcriptomic patterns uncoupled from genomic drivers
... However, claudin-low tumors also express high levels of immunosuppressive ...duced claudin-low-like tumors, we observed an elevated expression of two particularly notable genes involved in ...
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Neutralization of IL-8 decreases tumor PMN-MDSCs and reduces mesenchymalization of claudin-low triple-negative breast cancer
... as claudin-low (BT549, Hs578T, MDA- MB-436, and MDA-MB-231), two as basal like (HCC1143 and SUM149PT), and two as luminal (MCF7 and ...the claudin-low and basal-like cell lines secreted ...
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<p>The Expression and Prognostic Significance of Claudin-8 and Androgen Receptor in Breast Cancer</p>
... on cancer cells' survival and ...in breast cancer ...level. Low CLDN8 expression was associated with lymph nodes metastasis, high histological grade, negative ER, negative PR, high Ki-67 ...
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EpCAM based capture detects and recovers circulating tumor cells from all subtypes of breast cancer except claudin-low
... For reverse transcription the qScript cDNA SuperMix (Quanta Biosciences, Gaithersburg, MD) was used according to the user guide. RNA was isolated from BT474 cells using TRIzol reagent (Life Technologies, Carlsbad, CA) ...
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Murine mammary tumor cells with a claudin-low genotype
... of claudin-low tumors (MDA-MB- 435, MDA-MB-436, Hs578T, BT549, MDA-MB-231, MDA-MB-157, SUM1315MO2, SUM159PT and HBL100), fewer claudin-low, murine mammary tumor cell lines have been ...
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5722.pdf
... interesting genes to initially study. Rnf130 is a putative E3 ubiquitin ligase preferentially expressed in the mesoderm during development (Guais et al, 2006). It is hypothesized that Rnf130 may regulate apoptosis in ...
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Assessment of CXC ligand 12 mediated calcium signalling and its regulators in basal like breast cancer cells
... B) breast cancer cell lines, the effect of EMT induction on CXCR4, CXCR7, CD24 and HIF2 α expres‑ sion in MDA‑MB‑468 cells was ...and Claudin‑4, as well as CD24, and changes to a more spindle ...
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Claudin-5 is involved in breast cancer cell motility through the N-WASP and ROCK signalling pathways
... between Claudin-5 and N-WASP or Claudin-5 and ROCK 1 as well as whether any dir- ect effect was occurring at the protein level of these molecules in the control and transfected ...with Claudin-5, ...
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PubMedCentral-PMC5669567.pdf
... published breast cancer database (Molecular Taxonomy of Breast Cancer Inter- national Consortium [METABRIC]; ...of claudin-low tumors from the TCGA database ...clinical ...
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Phenotypic and molecular characterization of the claudin low intrinsic subtype of breast cancer
... of claudin-low tumors, we created a large genomic data set by com- bining three of our previously published data sets [5,6,9] and included 37 new tumor samples (n = 337; UNC337, GEO series ...the ...
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Pfefferle_unc_0153D_15508.pdf
... human breast tumors [6], which consist of multiple histological and genomic subtypes; these genomic groups, which are defined by their gene expression profiles, have become known as the intrinsic subtypes of ...
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Gene expression profiles of breast biopsies from healthy women identify a group with claudin-low features
... normal breast tissue (all cell types included) from women with no malignant disease has been performed only to a limited extent so far, in studies with other aims and with few samples ...normal breast ...
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Prognostic Implications of Claudin 4 and Rock 1 in Triple Negative Breast Cancer
... with low levels of ROCK I; ...human breast cancer, with the possible use of ROCK inhibitors acting as antimetastatic chemotherapeutic agents ...
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Integral membrane protein 2A inhibits cell growth in human breast cancer via enhancing autophagy induction
... Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved stress-responsive process that degrades and recycles superfluous or potentially dangerous cytosolic entities (e.g., damaged mitochondria, ...
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