colon carcinogenesis
Brewers’ rice induces apoptosis in azoxymethane induced colon carcinogenesis in rats via suppression of cell proliferation and the Wnt signaling pathway
... The colon tumor multiplicity did not significantly differ between the AOM-alone group and the group fed with diets containing 10% (w/w) brewers’ rice, between the AOM-alone group and 20% (w/w) brewers’ rice ...the ...
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Bacteroides fragilis subverts mucosal biology: from symbiont to colon carcinogenesis
... IL-17A–predominant colon inflammation with modest colon epithelial cell hyperplasia, foci of STAT3 activation, ROS production, and DNA damage ...in colon cancer ...
8
Epimorphin deletion protects mice from inflammation induced colon carcinogenesis and alters stem cell niche myofibroblast secretion
... Epithelial-mesenchymal interactions regulate normal gut epithelial homeostasis and have a putative role in inflammatory bowel disease and colon cancer pathogenesis. Epimorphin is a mesenchymal and myofibroblast ...
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Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis
... We have described in this review how the combination of the persistent damage to a cell’s genome with the inability of that cell to adequately repair the damage or die in response to the excessive damage, is a dangerous ...
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Thymoquinone Suppresses Cellular Proliferation, Inhibits VEGF Production and Obstructs Tumor Progression and Invasion in the Rat Model of DMH Induced Colon Carcinogenesis
... (DMH)-induced colon carcinogenesis in the rat model through a two-phase study (initiation and post-initiation) and to evaluate its potential impact on tumor progres- sion and invasion in ...DMH-induced ...
11
Maspin is a deoxycholate-inducible, anti-apoptotic stress-response protein differentially expressed during colon carcinogenesis
... sporadic colon cancer may then reflect the proliferation of persistently stressed clones of ...of colon carcinogenesis, which may be accentuated by a decrease in key DNA repair proteins, for ...
15
Grape compounds suppress colon cancer stem cells in vitro and in a rodent model of colon carcinogenesis
... CD133-positive colon CSCs were shown to be resistant to the conventional cytotoxic drug 5- florouracil and the resistance was shown to be dependent on Wnt signaling ...most colon cancers ...of colon ...
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Human colon carcinogenesis is associated with increased interleukin-17-driven inflammatory responses
... to carcinogenesis in human colorectal ...in colon carcinogenesis in mouse ...human colon adenocarcinomas, 16 cases of human normal colon tissues adjacent to the resected colon ...
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Hydrophobic bile acids, genomic instability, Darwinian selection, and colon carcinogenesis
... Sporadic colon cancer is caused predominantly by dietary ...of colon epithelial cells to hydrophobic bile acids can result in the activation of pro-survival stress-response pathways, and the modulation of ...
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Sphingosine 1 phosphate lyase downregulation promotes colon carcinogenesis through STAT3 activated microRNAs
... in colon cancer, as gut epithelial cells are exposed to sphingolipid metabolites generated by the breakdown of dietary sphingolipids ...and colon cancer ...in colon cancer (17, 20, ...and ...
18
Luteolin induces apoptosis in azoxymethane induced colon carcinogenesis through the involvement of Bcl 2, Bax and Caspase 3
... Flavonoids are important phytochemicals characterized by a common benzo-γ-pyrone chemical structure and found widely in different plants, especially in genus Citrus [14, 15]. Luteolin, (3’,4’,5,7-tetrahydroxyflavone) is ...
6
DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice
... Chronic inflammation increases cancer risk. While it is clear that cell signaling elicited by inflammatory cytokines promotes tumor development, the impact of DNA damage production resulting from inflamma- ...
11
Effect of Rumex Abyssinicus on preneoplastic lesions in dimethylhydrazine induced colon carcinogenesis in rats
... Method: Colon cancer chemopreventive potential of hydro-methanol extract of Rumex abyssinicus rhizome was determined based on the number and multiplicity of aberrant crypt foci ...
7
Synthetic triterpenoid induces 15 PGDH expression and suppresses inflammation driven colon carcinogenesis
... Colitis-associated colon cancer (CAC) develops as a result of inflammation-induced epithelial transforma- tion, which occurs in response to inflammatory cytokine-dependent downregulation of 15-hydroxypros- ...
12
The phosphatidic acid phosphatase lipin-1 facilitates inflammation-driven colon carcinogenesis
... Regarding colon tumorigenesis, PPARγ inhibits polyp development in the colon in a AOM/DSS model (52), but the role of other members of the PPAR family is less clear, and contradictory information exists ...
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Original Article JMJD5 is a potential oncogene for colon carcinogenesis
... Abstract: Objective: To observe the effects of Jumonji C domain-containing (JMJD) 5 depletion on colon cancer (CC). Methods: A short-hairpin RNA targeting JMJD5 was transfected into a lentivirus to make Lv-shJMJD5 ...
8
Inhibition of 11β–hydroxysteroid dehydrogenase type II selectively blocks the tumor COX 2 pathway and suppresses colon carcinogenesis in mice and humans
... Human colon carcinoma HCA-7 cells constitutively expressed both 11βHSD2 and COX-2 (Supplemental Figure 6A), and COX-2 activity is essential for the proliferation of HCA-7 cells ...human colon carcinoma ...
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Mechanisms linking obesity to altered metabolism in mice colon carcinogenesis
... murine colon cancer cells to adipose tissue preparations from mice fed CD or ...human colon cancer cells ...in colon cancer cell lines, we measured leptin levels in the different CM ...
15
INHIBITION OF CARSINOGENESIS BY SEED AND SOYBEAN MEAL EXTRACT IN COLON OF MICE: APOPTOSIS AND DYSPLASIA
... DMH-induced colon cancer by increasing the level of antioxidant ...of colon carcinogenesis by reducing the inflammation, hyperplastic, dysplastic change in colon crypt cells ...in colon ...
6
Expression of miRNA in different regions of the colon: An investigation in Zucker(fa/fa) rats
... of colon carcinogenesis is more effective in retarding the growth of distal developing ...distal colon and tumors whereas has an opposite effect on the ACF or tumors developing in the proximal ...
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