Complement receptor type 2 or Epstein-Barr virus/C3d receptor
Molecular Basis of the Interaction between Complement Receptor Type 2 (CR2/CD21) and Epstein-Barr Virus Glycoprotein gp350
... the Epstein-Barr virus glycoprotein gp350 by complement receptor type 2 (CR2) is critical for viral attachment to B ...
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Identification of gp350 as the viral glycoprotein mediating attachment of Epstein-Barr virus (EBV) to the EBV/C3d receptor of B cells: sequence homology of gp350 and C3 complement fragment C3d.
... COOPER Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, California 92037 The major Epstein-Barr virus EBV envelope glycoprotein, gp350, was purified from the B[r] ...
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Characterization of a T-lymphocyte Epstein-Barr virus/C3d receptor (CD21).
... Internal amino acid sequences derived from tryptic peptides and a partial cDNA clone demonstrates that EBV CR2 EBVR-CR2 is homologous to complement receptor type 1 CR1 19, 54, which plac[r] ...
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Epstein-Barr Virus-Encoded BILF1 Is a Constitutively Active G Protein-Coupled Receptor
... e.g., Epstein-Barr virus (EBV), unlike ␥ 2-herpesviruses, ...Most virus-encoded GPCRs, including UL33, M33, R33, UL78, M78, R78, US27, and US28 (6, 7, 10, 18, 41, 42, 60), are ...
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Distinct Roles of Extracellular Domains in the Epstein Barr Virus Encoded BILF1 Receptor for Signaling and Major Histocompatibility Complex Class I Downregulation
... the receptor- induced signaling and MHC class I downregulation, we generated 24 point mutations in the EBV-BILF1 extracellular domain and a mutant, where the first 17 residues of the receptor N terminus were ...
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Functional Replacement of the Intracellular Region of the Notch1 Receptor by Epstein-Barr Virus Nuclear Antigen 2
... Notch1 and EBNA2 interact with similar but not identical regions of RBP-J. To identify regions of RBP-J that interact with EBNA2 and RAMIC of mouse Notch 1, a series of RBP-J mutants was tested in the yeast two-hybrid ...
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Analysis of Host Gene Expression Changes Reveals Distinct Roles for the Cytoplasmic Domain of the Epstein-Barr Virus Receptor/CD21 in B-Cell Maturation, Activation, and Initiation of Virus Infection
... and 2 (20) ...1E). Type Ia plasma membrane proteins with short intracellular domains of less than 10 amino acids sometimes become tethered to the cytoplasm by lipid, specifically glycosyl ...
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Epstein-Barr Virus Induces Adhesion Receptor CD226 (DNAM-1) Expression during Primary B-Cell Transformation into Lymphoblastoid Cell Lines
... Loss of CD226 does not impact LCL growth, susceptibility to apoptosis, homo- typic aggregation, or binding to activated endothelial cells. To investigate the function of CD226 in LCLs, we utilized the clustered regularly ...
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Identification and characterization of the Epstein-Barr virus receptor on human B lymphocytes and its relationship to the C3d complement receptor (CR2).
... Consistent with the ability of antibody OKB7 to inhibit the binding of EBV to tonsil B lymphocytes and Raji lymphoblastoid cells directly, this antibody also directly blocked EBV infecti[r] ...
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The Epstein-Barr virus latent membrane protein 1 regulates gene expression by engaging multiple signaling pathways
... Epstein-Barr virus (EBV) is a ubiquitous human gammaherpesvirus that is associated with a variety of human malignancies of lymphoid and epithelial origins, such as post- transplant ...
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Manipulation of the Toll-Like Receptor 7 Signaling Pathway by Epstein-Barr Virus
... in type III cell lines therefore suggested that, as is the case for IRF-7, EBV must modulate IRF-5 activity to balance the positive and negative downstream ...all type III latently infected cells expressing ...
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Healthy rabbits are susceptible to Epstein Barr virus infection and infected cells proliferate in immunosuppressed animals
... B95-8 cells (EBV producer cell line) [2] were cultured in RPMI-1640 (GIBCO, USA), supplemented with 10% FBS (GIBCO, USA), 1% antibiotic antimycotic solution (Santa Cruz, UK), 50 μg/ml gentamycin (Hyclone, USA) and ...
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The signaling pathways of Epstein-Barr virus-encoded latent membrane protein 2A (LMP2A) in latency and cancer
... encodes 2 isoforms of the hydrophobic integral membrane protein, namely LMP2A and LMP2B ...B-cell receptor (BCR) signal transduction upon BCR cross-linking ...
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Immunotherapy in head and neck cancer: aiming at EXTREME precision
... The idea of immunosurveillance was quickly ques- tioned by findings in athymic nude mice exhibiting no increased susceptibility to chemically induced or spontan- eous carcinogenesis compared with immunocompetent mice. ...
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Presence of Epstein-Barr virus receptors, but absence of virus penetration, in cells of an Epstein-Barr virus genome-negative human lymphoblastoid T line (Molt 4).
... Copyright © 1977 American Society for Microbiology NOTES Presence of Epstein-Barr Virus Receptors, but Absence of Virus Penetration, in Cells of an Epstein-Barr Virus GenomeNegative Huma[r] ...
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Epstein Barr virus and cytomegalovirus infections and their clinical relevance in Egyptian leukemic pediatric patients
... The median age of the 50 pediatric leukemic patients was 7 years (range: 9.5 months–18 years) while that of the 30 healthy controls was 11 years (range: 4–18 years). Male to female ratio was 1.08:1 in patients, and ...
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Epstein-Barr Virus Latent Membrane Protein 1 Induces Expression of the Epidermal Growth Factor Receptor through Effects on Bcl-3 and STAT3
... regulation, apoptosis, and oncogenesis (21, 38). There are five mammalian NF- B family members, including p50, p52, p65 (RelA), c-Rel, and RelB. The activation of NF- B family members is regulated through ...
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Genomic Diversity of Epstein-Barr Virus Genomes Isolated from Primary Nasopharyngeal Carcinoma Biopsy Samples
... other type-independent genes might tell a different ...the type 1 and 2 dichotomy, suggesting that LMP1 and -2 genes can serve as geographical ...the virus (52, ...region 2 (HR2) ...
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The Epstein Barr virus EBNA1 protein modulates the alternative splicing of cellular genes
... simplex virus 1 (HSV-1) and its immediate early ICP27 ...by Epstein-Barr virus (EBV), another virus from the herpesviridae family involved in numerous cancers (such as Burkitt ’ s and ...
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A Single Amino Acid in EBNA-2 Determines Superior B Lymphoblastoid Cell Line Growth Maintenance by Epstein-Barr Virus Type 1 EBNA-2
... of type 2 EBNA leader pro- tein (EBNA-LP) and EBNA-3 ...a type-specific cooperation with EBNA-LP but could find no evidence for that ...whether type-spe- cific EBNA-3 effects could also ...
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