complementarity determining region (CDR)
Relationship between Antibody 2F5 Neutralization of HIV-1 and Hydrophobicity of Its Heavy Chain Third Complementarity-Determining Region
... external region (MPER) of the HIV-1 gp41 transmembrane glycoprotein is the target of the broadly neutralizing antibody ...third complementarity-determining region of the heavy chain ...
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Characterization of the immunoglobulin heavy chain complementarity determining region (CDR) III sequences from human B cell precursor acute lymphoblastic leukemia cells
... chain complementarity determining region (CDR)-III of B-lineage cells at various stages has provided important insights concerning B cell maturation and ...human CDR-III sequences has ...
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Homologous regions of autoantibody heavy chain complementarity determining region 3 (H CDR3) in patients with pemphigus cause pathogenicity
... Pemphigus is a life-threatening autoimmune disease in which antibodies specific for desmogleins (Dsgs) cause loss of keratinocyte cell adhesion and blisters. In order to understand how antibodies cause pathogenicity and ...
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Ablation of the Complementarity-Determining Region H3 Apex of the Anti-HIV-1 Broadly Neutralizing Antibody 2F5 Abrogates Neutralizing Capacity without Affecting Core Epitope Binding
... extended CDR H3 ...the CDR H3 extended loop of 4E10, in conjunction with positively charged pockets near the paratope, is responsible for the ex- traction of the gp41 core epitope partitioned at the ...
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Domain swapping of complementarity-determining region in nanobodies produced by Pichia pastoris
... preparing CDR and scaffold fragments are easily randomized or mutated, this method could be useful in producing large-scale libraries of chimeric nanobodies for high-throughput screening, including screening ...
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Molecular features of the complementarity determining region 3 motif of the T cell population and subsets in the blood of patients with chronic severe hepatitis B
... When the GMSP analysis of a sample demonstrated a TCRBV family monoclonal profile (single peak), the cor- responding TCRBV gene family was selected for cloning and sequencing to characterize and determine the degree of ...
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A complete, multi level conformational clustering of antibody complementarity determining regions
... antibody complementarity-determining region (CDR) conforma- tions is an important step that drives antibody modelling and engineering, prediction from sequence, directed mutagenesis and ...
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Bovine cryptosporidiosis: impact, host-parasite interaction and control strategies
... ferentiation; CDR: complementarity-determining region; cm: centimetre; DCs: dendritic cells; DNA: deoxyriboneucleic acid; GALT: gut associated lymphoid tissue; GM-CSF: granulocyte-macrophage ...
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What you should know about PR3 ANCA: Structural aspects of antibodies to proteinase 3 (PR3)
... variable region of the heavy chain and thus was accessible for interaction with pre- sumably positively charged residues on ...CDR3 region of the antibody was engaged, it appeared to be only at the edge of ...
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Oligoclonal expansion of TCR Vδ T cells may be a potential immune biomarker for clinical outcome of acute myeloid leukemia
... The complementarity-determining region 3 (CDR3) sizes of eight TCR Vδ subfamily genes ( TRDV1 to TRDV8 ) were analyzed in sorted γδ T cells using RT-PCR and ...
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Reduced T cell repertoire restrictions in abatacept treated rheumatoid arthritis patients
... by complementarity-determining region-3 (CDR3) spectra- typing after TCR beta variable (TCRBV) gene multiplex PCRs that allow the detection of 23 functional TCRBV families starting from 500 ng of ...
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Sequence analysis of T-cell repertoires in health and disease
... constant region (green) of the TCR is anchored to the cell membrane, followed by the J region ...J region is followed by the V region (orange), whereas in TCR β chains, a D region is ...
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Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes
... (IGH) complementarity determining region 3 (CDR3) amino acid (AA) sequences shared across the pancreatic draining lymph node (pLN, yellow), spleen (blue), and “irrel- evant” mesenteric and/or ...
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The expanding array of HIV broadly neutralizing antibodies
... chain complementarity determining region (CDRH3) in what was termed a “hammerhead” structure to bind to the V1/V2 at the very top of the Env trimer where the three gp120 subunits meet to form the ...
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IDENTIFICATION OF ANTIBODY TARGETS USING PHOTOACTIVATED CROSS LINKERS LOCATED IN THE BINDING SITE
... the complementarity determining region (CDR3) of the variable heavy (V H ) chain to allow the incorporation of the amber codon (TAG) in DNA and ...
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CDR Search User Guide
... When you log in for the first time, you need to know either the IP address or the name of the server you’ll be linking to. (If you use the server name rather than the IP address, CDR Search replaces the name with ...
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2011 iswcs df cdr
... our CDR Scheme 2 here, because U does not need to receive any message, RS only needs to adapt the rate to RS– BS channel and therefore a higher rate for the transmission can be chosen considering the relay side of ...
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2011 icc af cdr
... The complexity for CDR with exhaustive search, however, is prohibitively high since we have to calculate the sum–rate for every permutation of the packets. It is necessary to propose some sub-optimal schemes which ...
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Complementarity in Time between Hydro, Wind and Solar Energy Resources in the State of Rio Grande do Sul, in Southern Brazil
... This complementarity could be obtained from the difference between the availability periods of the solar and wind energy sources, in order to satisfy the demand, obtaining in this way an increase of reliability ...
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Synergy between trastuzumab and pertuzumab for human epidermal growth factor 2 (Her2) from colocalization: an in silicobased mechanism
... membrane region, a tyrosine kinase domain, and a C- terminal tail harboring autophosphorylation sites that serve as docking sites for adaptor proteins ...a region that is not involved ...
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