Complex phenotypes
Optimizing complex phenotypes through model guided multiplex genome engineering
... Leveraging recent improvements in the cost and speed of microbial whole-genome sequencing (WGS), we present a method for identifying precise genomic changes that optimize complex phenotypes, combining ...
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Incorporating Gene Annotation into Genomic Prediction of Complex Phenotypes
... ABSTRACT Today, genomic prediction (GP) is an established technology in plant and animal breeding programs. Current standard methods are purely based on statistical considerations but do not make use of the abundant ...
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Retinal nerve fibre layer loss in hereditary spastic paraplegias is restricted to complex phenotypes
... with complex forms of HSP where the disease spreads beyond the long fibre tracts presented significant thinning of RNFL especially in temporal and temporal inferior ...
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Sharing of Genes and Pathways Across Complex Phenotypes: A Multilevel Genome-Wide Analysis
... human complex phenotypes are very ...among complex phenotypes has broadened our understanding of human diseases and ...24 phenotypes previously investigated for genetic ...across ...
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Quantitative Genomics of 30 Complex Phenotypes in Wagyu x Angus F1 Progeny
... plants do not synthesize CLA [66]. Three genes, EFEMP1, PLTP, and DSEL, were involved in the CLA network. PLTP is a lipid transfer protein that belongs to the lipopolysaccharide family. Previous reports revealed that ...
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Manganese homeostasis: from rare single gene disorders to complex phenotypes and diseases
... ence phenotypes through modulation of the activity of certain Mn-dependent enzymes including transferases, hydro- lases, lyases, isomerases, and oxidoreduc- tases ...
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The Long Way from Complex Phenotypes to Genes: The Story of Rat Chromosome 4 and Its Behavioral Effects
... As discussed in this review, several QTLs analyses using different animal models have led to the identifica- tion of genomic regions on rat Chr. 4 related to different behavioral traits, such as anxiety-like and alcohol ...
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Understanding the Genetic Etiology of Complex Phenotypes using Bayesian Neural Networks.
... Many popular machine learning algorithms have also been adopted for use in analyzing association studies. Notable examples are decision trees (both bagged, i.e. random forests, [Lunetta et al., 2004, Diaz-Uriarte and de ...
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Statistical Methods for Identifying X-linked Genes Associated with Complex Phenotypes
... Complex disorders that are caused by mutations in genes on the X chromo- some are described as X-linked. X-linked recessive traits such as hemophilia A & B, and red-green color blindness, are not expressed in ...
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Yu, Zhonghao (2013): Metabolomics analyses to better understand complex phenotypes. Dissertation, LMU München: Medizinische Fakultät
... two phenotypes in serum but not in plasma are, nevertheless, close to the significance level when plasma was used, an observation that is in agreement with the existence of high correlations between both ...
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Adenovirus E4-dependent activation of the early E2 promoter is insufficient to promote the early-to-late-phase transition.
... DISCUSSION Adenovirus E4 deletion mutants, such as dl808, show very complex phenotypes, including defects in viral DNA replication, late gene expression, and shutoff of host cell protein[r] ...
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Reliability of genomic predictions of complex human phenotypes
... for complex phenotypes [3]. Evidence suggests that complex traits are influenced by many genes, with effects that often fall below statistical significance thresholds ...
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Rai1 duplication causes physical and behavioral phenotypes in a mouse model of dup(17)(p11 2p11 2)
... the complex physical and behavioral phenotypes observed in Dp(11)17/+ mice, despite altered trisomic copy number of the other 18 genes present in the rearranged genomic ...
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Molecular and biochemical basis of intermediate maple syrup urine disease Occurrence of homozygous G245R and F364C mutations at the E1 alpha locus of Hispanic Mexican patients
... (BCKAD) complex. The multienzyme complex comprises five enzyme components, including the E1 decarboxylase with a heterotetrameric (alpha 2 beta 2) ...
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Evidence for an ecological cost of enhanced herbicide metabolism in Lolium rigidum
... both phenotypes displayed a similar ability to reduce the growth of S target plants (Table 1; ...between phenotypes which are solely the result of differences in plant size should not be apparent when ...
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Isolation and characterization of genes involved in DNA damage response and telomere maintenance in Caenorhabditis elegans
... previously been identified, for example: a deletion mutant of him-6, which encodes the BLM helicase ortholog, displays a mutator phenotype and other genomic instability phenotypes, modestly shortened lifespan and ...
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Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters
... Our results are consistent with physiological data suggesting the presence of 4 different transporters for proline and glycine in the kidney, namely the common transporter SLC36A2, the s[r] ...
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Analysis of arterial intimal hyperplasia: review and hypothesis
... To explain disease-related hyperplasia that is not preceded by changes in hemodynamics and shear stress, I hypothe- size that the arterial blood-tissue interface itself (as a top- ological entity) imposes properties that ...
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Biochemical basis of prolidase deficiency Polypeptide and RNA phenotypes and the relation to clinical phenotypes
... Cultured skin fibroblasts or lymphoblastoid cells from eight patients with clinical symptoms of prolidase deficiency were analyzed in terms of enzyme activity, presence of material crossreacting with specific antibodies, ...
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The evolution of morph-biased genes in spadefoot toads
... Over the past 20 years, research on phenotypic plasticity has come into the mainstream of evolutionary biology. Yet, it still remains unclear what type of genes are recruited during the evolution of adaptively plastic ...
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